List Diseases – I
Ichthyosis is a group of hereditary skin diseases characterized by a disturbance of keratinization. Causes and pathogenesis are not fully understood. Many forms of ichthyosis are based on mutations or disturbances in the expression of genes encoding various forms of keratin. With lamellar ichthyosis deficiency of transglutaminase keratinocytes and proliferative hyperkeratosis are noted.
The leading symptom of erythroderma is expressed in this or that degree, against which there is an ecdysis according to the type of ichthyosis. This clinical picture also corresponds to similar histological changes (with the exception of bullous ichthyosiforme): in the form of hyperkeratosis, to varying degrees of acanthosis and inflammatory changes in the dermis.
Iatrogenic injuries and bladder injuries occur in laparoscopic operations 2-10 times more often than in open surgeries.