Diagnosis of autoimmune diseases

Samples of Coombs

Direct Coombs test - antiglobulin test (agglutination in the gel, allows to identify complete bivalent antibodies), by which antibodies of the IgG class and the C3 complement component on the erythrocyte surface are determined.

Antibodies to Saccharomyces cerevisiae in the blood

Saccharomyces cerevisiae are unicellular fungi, commonly known as "baker's yeast." Antibodies to Saccharomyces cerevisiae of class IgG and IgA are directed against the oligomannan epitope of mannan (phosphopeptidomannan) of the yeast cell membrane.

Antibodies to tissue transglutaminase in the blood

Tissue transglutaminase belongs to a family of calcium-dependent acyltransferases that catalyze the formation of cross-links between proteins. It has now been established that tissue transglutaminase is the main, if not the only endomysial antigen in patients with celiac disease.

Antibodies to the gliadin in the blood

Elevated levels of antibodies to gliadin in the blood serum can be detected in 25% of patients with herpetiform dermatitis and autoimmune diseases.

Antibodies to the tubular basement membrane in the blood

Tubulointerstitial nephritis is an inflammatory disease of the kidneys of a noninfectious nature with the localization of the pathological process in the interstitial (interstitial) tissue and the damage to the tubular nephron apparatus.

Antibodies to the basal membrane of the glomeruli in the blood

The presence of antibodies to the basal membrane of the glomeruli (anti-BMC) is most typical for patients with fast-progressive glomerulonephritis (anti-BMC glomerulonephritis). All patients with anti-BMC glomerulonephritis can be divided into two groups: only with kidney pathology and Goodpasture's disease (50%), in which the latter is combined with pulmonary.

Laboratory Diagnosis of Autoimmune Kidney Disease

Glomerulonephritis is the most common form of primary kidney disease with a predominant lesion of the renal glomeruli. Currently, the concept of the immunoinflammatory genesis of this disease is generally recognized.

Antibodies to serum endothelium

Antibodies to the vascular endothelium are often found in vasculitis, especially with Kawasaki disease. It is suggested that antibodies to the endothelium may damage endothelial cells through complement dependent cytolysis or antibody-dependent cellular cytotoxicity.

Antibodies to myeloperoxidase of neutrophils in the blood

Myeloperoxidase is a protein with a molecular weight of 59,000, which is one of the main factors that ensure bactericidal protection of a person. Antibodies to myeloperoxidase of neutrophils may appear in vasculitis

Antibodies to a protein that enhances the bactericidal effect of neutrophils

The protein, which enhances the bactericidal action of neutrophils, is a membrane protein of neutrophils and monocytes. Its main function is to bind endogenes of bacteria. Antibodies to this protein are most often found in Crohn's disease and ulcerative colitis.


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