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Antibodies to tissue transglutaminase in the blood
Last reviewed: 23.04.2024
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The separation point is the antibody to tissue transglutaminase in serum above 10 IU / ml for IgA, and above 10 IU / ml for IgG.
Tissue transglutaminase belongs to a family of calcium-dependent acyltransferases that catalyze the formation of cross-links between proteins. It has now been established that tissue transglutaminase is the main, if not the only endomysial antigen in patients with celiac disease.
Determination of antibodies to tissue transglutaminase in blood serum is a highly specific method for diagnosing gluten enteropathy. For the detection of antibodies, the method of indirect immunofluorescence and ELISA is used. Antibodies to tissue transglutaminase can be detected in more than 95% of patients with celiac disease and their serum concentration correlates with the presence or absence of gluten in food. Antibodies of IgA class possess 95-100% sensitivity and 90-97% specificity.
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