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Antibodies to Saccharomyces cerevisiae in blood
Last reviewed: 05.07.2025
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The cut-off point is considered to be the content of antibodies to Saccharomyces cerevisiae in the blood serum above 10 IU/ml for IgA, above 10 IU/ml for IgG.
Saccharomyces cerevisiae is a single-celled fungus commonly known as "baker's yeast". IgG and IgA antibodies to Saccharomyces cerevisiae are directed against the oligomannan epitope of mannan (phosphopeptidomannan) of the yeast cell membrane. IgG and IgA antibodies toSaccharomyces cerevisiae are closely associated with Crohn's disease and have a specificity of 95-100%. IgG antibodies to Saccharomyces cerevisiae are detected in only 5% of patients with ulcerative colitis, and IgA antibodies in 7%. The diagnostic sensitivity of IgG antibodies for diagnosing Crohn's disease is 75%, for IgA - 60%.
The combined determination of p-ANCA and IgG and IgA antibodies to Saccharomyces cerevisiae in serum increases the specificity of differential diagnosis between Crohn's disease and ulcerative colitis to 99%. The presence of any class of antibodies to Saccharomyces cerevisiae in serum and the absence of antibodies to neutrophil cytoplasm has 95-100% specificity and 50% sensitivity for Crohn's disease; the absence of antibodies to Saccharomyces cerevisiae and the presence of antibodies to neutrophil cytoplasm allows for the diagnosis of ulcerative colitis with 90-100% specificity and 50-60% sensitivity.
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