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Antibodies to Saccharomyces cerevisiae in the blood
Last reviewed: 23.04.2024
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The separation point is the content of antibodies to Saccharomyces cerevisiae in the serum above 10 IU / ml for IgA, above 10 IU / ml for IgG.
Saccharomyces cerevisiae are unicellular fungi, commonly known as "baker's yeast." Antibodies to Saccharomyces cerevisiae of class IgG and IgA are directed against the oligomannan epitope of mannan (phosphopeptidomannan) of the yeast cell membrane. IgG and IgA antibodies to Saccharomyces cerevisiae are closely related to Crohn's disease and have a specificity of 95-100%. IgG antibodies to Saccharomyces cerevisiae are detected in only 5% of patients with ulcerative colitis, and IgA antibodies in 7%. The diagnostic sensitivity of the detection of IgG antibodies for diagnosis of Crohn's disease is 75%, for IgA, 60%.
The combined determination of p-ANCA and anti-IgG and IgA antibodies to Saccharomyces cerevisiae in the serum increases the specificity of the differential diagnosis between Crohn's disease and ulcerative colitis to 99%. The presence of any class of antibodies to Saccharomyces cerevisiae in the serum and the absence of antibodies to the cytoplasm of neutrophils possess 95-100% specificity and 50% sensitivity for Crohn's disease; the absence of antibodies to Saccharomyces cerevisiae and the presence of antibodies to the cytoplasm of neutrophils makes it possible to diagnose ulcerative colitis with 90-100% specificity and 50-60% sensitivity.
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