Antibodies to the gliadin in the blood
Last reviewed: 23.04.2024
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The separation point is the antibody content to gliadin in serum above 15 IU / ml for IgA, and above 35 IU / ml for IgG.
In patients with untreated glutein enteropathy, the concentration of IgA and IgG antibodies to α-gliadin significantly increases in the serum (8-10 times or more during the exacerbation of the disease). The sensitivity of the IgA antibody detection for the diagnosis of enteropathy is 87-100%, the specificity is 62-94.5%. The detection of IgG antibodies is more sensitive, but less specific. Identification of antibodies to gliadin in the blood is considered an additional indication for biopsy of the small intestine mucosa with subsequent morphological examination of biopsies. Effective treatment is accompanied by a decrease in the concentration of IgA antibodies to normal values in most patients within 3-4 weeks, a decrease in the IgG antibody content at these times is less pronounced (remains elevated in 50% of patients).
Elevated levels of antibodies to gliadin in the blood serum can be detected in 25% of patients with herpetiform dermatitis and autoimmune diseases.
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