Medical expert of the article
New publications
Antibodies to neutrophil myeloperoxidase in blood
Last reviewed: 05.07.2025
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Normally, antibodies to neutrophil myeloperoxidase are absent in the blood serum.
Myeloperoxidase is a protein with a molecular weight of 59,000, which is one of the main factors providing human bactericidal protection. Antibodies to neutrophil myeloperoxidase may appear in vasculitis (microscopic polyangiitis - in 60-65% of cases, Churg-Strauss - in 17-20%), rheumatoid arthritis, systemic lupus erythematosus, Goodpasture's syndrome.
Frequency of detection of different types of antibodies in vasculitis
AT detection rate,% |
|||
Type of AT |
Wegener's granulomatosis |
Microscopic polyangiitis |
Churg-Strauss syndrome |
| ANCA | 85-95 |
75-95 |
65-75 |
| AT to protein kinase-3 | 75-80 |
25-35 |
10-15 |
Anti-MP |
10-15 |
50-60 |
55-60 |
[