The pharmacological action that the suppository exerts on the inflammation of the vagina and cervix of the uterus is Hexicon - antiseptic and bactericidal; The active component of this agent is cationic polybiguanide chlorhexidine (in the form of biguconate). At the physiological level of acidity in the vagina, dissociation and release of the positively charged chlorhexidine cation occurs, which binds to the negatively charged cells of the lipoprotein membrane of bacteria and causes its destruction. Suppositories Gexicon act on the majority of gram-positive and gram-negative bacteria and fungi, so this is an effective suppository against inflammation.
Vaginal tablets Terzhinan have at once four active substances: azole compound (imidazole derivative) ternidazole, active against trichomonads and gardnerella; aminoglycoside antibiotic neomycin (acting mainly on gram-negative microorganisms); polyene antimycotin nystatin (fatal to C. Albicans due to damage to its cell membranes); synthetic corticosteroid prednisolone (reducing inflammation by blocking the activity of leukocytes and inhibiting the synthesis of inflammatory mediators).
It should be noted that the composition of the drug of the French manufacturer (Laboratoires Bouchara-Recordati) differs from that produced in the Russian Federation and Romania. Terjinan, used in the EU, contains metronidazole (instead of terinidazole), and there is no prednisolone at all.
Pharmacodynamics of the preparation Polyzhinaks is based on the action of the polypeptide antibiotic polymyxin B (which destroys the envelopes of gram-negative bacteria), already mentioned above antibiotic neomycin and polyene antibiotic nystatin.
Containing polyenic antibiotic natamycin (pimaricin) suppositories Pimafucin act only on C. Albicans, disrupting the integrity of their cell membranes of fungi and inhibiting the synthesis of sterol compounds.
The active substance of suppositories Betadin is povidone-iodine, which provides bactericidal and antifungal action due to the ability to coagulate proteins of pathogenic microorganisms.
And such anti-inflammatory suppositories as Eucalyamin contain the 1.8-cineole (eucalyptol), a turpentine substance, obtained from the leaves of eucalyptus; suppository help to relieve inflammation with vaginitis, vulvovaginitis and cercivitis caused by staphylococci, streptococci and trichomonads.
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