Artifrin

"Artifrin" is a combined local anesthetic containing two active ingredients: articaine hydrochloride and epinephrine.

1. Articaine Hydrochloride: Is a powerful local anesthetic that is used to numb tissue in a specific area of the body before medical procedures or surgery. It blocks the transmission of nerve impulses and temporarily blocks sensitivity in the area of its application.
2. Epinephrine: Epinephrine is added to the drug as a vasoconstrictor, which means it narrows the blood vessels. This reduces bleeding in the area of application and prolongs the duration of action of articaine, reducing its absorption and increasing the duration of anesthesia.

Artifrin is commonly used in dentistry to provide local anesthesia for dental procedures such as tooth extractions or root canals. It can also be used in other medical fields to provide local anesthesia.

It is important to note that the use of Artifrin should only be done under the supervision of a qualified medical professional due to possible serious side effects such as allergic reactions, possible heart problems and high blood pressure.

Indications Artifrina

• Dental procedures: Artifrin is often used by dentists to administer local anesthesia for various dental procedures, such as:

  • Teeth removal.
  • Root canal treatment.
  • Treatment of periodontitis (inflammation of the tissues surrounding the teeth).
  • Prosthetics and dental implantation.

• Minor surgical procedures: In some cases, Artifrin can be used for local anesthesia for minor surgical procedures, such as the removal of small skin growths.

• Medical procedures: In a number of medical fields, Artifrin can be used for local anesthesia for other procedures requiring numbing of small areas of the body.

Release form

Artifrin is usually supplied as an injection solution. This solution contains two active ingredients: articaine hydrochloride and epinephrine. Usually "Artifrin" is supplied in ampoules or bottles with volumes ranging from several milliliters to several tens of milliliters.

Pharmacodynamics

• Articaine hydrochloride: It is a local anesthetic from the amide group. It acts by blocking the conduction of nerve impulses along nerve fibers, which temporarily leads to loss of sensitivity in the area of its application.
• Epinephrine: Epinephrine is added to the drug as a vasoconstrictor. This means that it constricts the blood vessels in the area where it is applied. This reduces bleeding in the area of application and increases the duration of action of articaine, slowing down its absorption.

Pharmacokinetics

1. Articaine hydrochloride: Articaine is absorbed from locally administered tissues and is rapidly metabolized in the liver to form inactive metabolites. The onset of action of articaine is usually a few minutes after injection.
2. Epinephrine: Epinephrine administered topically is also rapidly absorbed from tissues and exerts its vasoconstrictor effects at the site of application. In this regard, the duration of action of articaine increases, which allows prolongation of anesthesia.

Together, these two components form a complex that provides effective pain relief and reduces the risk of bleeding in the area of application. Typically, the duration of action of "Artifrin" is several hours.

Dosing and administration

• Dosage: Artifrin is usually administered as an injection into the local area requiring pain relief, as directed by your dentist or physician. Dosage may vary depending on the type and complexity of the procedure, as well as the individual needs of the patient.
• Number of Injections: The number of injections may also vary depending on the size of the area that needs to be numbed and the type of procedure.
• Frequency of use: Artifrin is usually applied immediately before the start of the procedure and can be repeated if necessary during the procedure.
• Maximum dose: The maximum dose of Artifrin is determined taking into account the maximum safe dose of articaine and epinephrine, taking into account possible side effects and risks.

Use Artifrina during pregnancy

The use of "Artifrin" (articaine hydrochloride, epinephrine) during pregnancy should be done with caution and only as prescribed by a doctor. Before using Artifrin, pregnant women should discuss the potential risks and benefits of this drug with their doctor.

It is important to understand that although local anesthetics such as articaine usually do not have systemic effects on the body when applied topically, the epinephrine contained in Artifrin as a vasoconstrictor may have systemic effects, including effects on the cardiovascular system. Therefore, the use of Artifrin during pregnancy should be limited and only when necessary.

The doctor must evaluate the benefits of using Artifrin for the mother and the potential risks for the fetus and make a decision based on the individual circumstances of each clinical case. If the use of Artifrine is necessary, it is usually preferable to use the minimum effective dose with a minimum amount of epinephrine.

Contraindications

• Hypersensitivity: Any of the components of Artifrin, including articaine hydrochloride, epinephrine or any other ingredients, may cause an allergic reaction in a person sensitive to them. Therefore, the drug should be used with caution in patients with a known allergy to lidocaine, articaine or other amide anesthetics.
• Tachycardia and arrhythmias: Artifrin contains epinephrine, which can cause increased cardiac activity. Therefore, it should be avoided in patients with severe cardiac arrhythmias, tachycardia or other cardiovascular diseases.
• Hypertensive crisis: Epinephrine may increase blood pressure and heart function, which may be dangerous for patients with a hypertensive crisis or high blood pressure.
• Thyrotoxicosis: Epinephrine may increase the symptoms of thyrotoxicosis and should be used with caution in patients with this condition.
• Patients with Pheochromocytoma: Epinephrine may cause serious reactions in patients with pheochromocytoma due to their increased sensitivity to catecholamines.

Side effects Artifrina

• Allergic reactions: Like other drugs containing anesthetics and epinephrine, Artifrin can cause allergic reactions in some patients, including anaphylactic shock.
• Cardiovascular effects: Epinephrine, which is part of Artifrin, can cause an increase in heart rate, blood pressure and heart rhythm. Some patients may experience palpitations, arrhythmias, or worsening myocardial ischemia.
• Cardiovascular complications: Use of epinephrine may result in serious cardiovascular complications such as myocardial infarction or stroke, especially in patients with pre-existing cardiovascular disease.
• Hypertension: Epinephrine can cause an increase in blood pressure, which can lead to hypertension and hypertensive crises.
• Local reactions: Various local reactions may occur at the Artifrin injection site, such as pain, swelling, hemorrhage or changes in skin color.
• Neurological symptoms: Some patients may experience neurological symptoms such as dizziness, headache, tremors, or paresthesia.
• Other rare reactions: Other rare side effects may occur, including injection site reactions, bradycardia, loss of consciousness, and other serious reactions.

Overdose

• Cardiac arrhythmias: Increased heart rate, irregular heart rhythm, or other cardiac arrhythmias.
• Hypertension: High blood pressure, which can lead to headaches, dizziness, or even more serious complications.
• Tachycardia: An increase in heart rate can cause a feeling of pulsation, palpitations and restlessness.
• Tremors and tremors: Nervous excitement can cause tremors and tremors in various parts of the body.
• Dizziness and Headache: Increased heart rate and changes in blood pressure can lead to dizziness and headache.

Interactions with other drugs

• Anesthetics: The use of Artifrin with other anesthetics may increase the risk of unwanted side effects, including toxic effects on the cardiovascular system.
• Drugs that affect the cardiovascular system: Epinephrine, which is part of Artifrin, may enhance the effect of other drugs that affect the cardiovascular system, such as beta blockers or drugs that increase blood pressure.
• Drugs that increase blood pressure: The use of Artifrin with drugs that increase blood pressure, such as sympathomimetics or monoamine oxidase inhibitors, can lead to a significant increase in blood pressure and possible serious complications.
• Drugs that reduce blood pressure: The use of Artifrin with drugs that reduce blood pressure can lead to a decrease in the effectiveness of the anesthetic and an increase in its systemic effects.
• Drugs affecting liver function: The use of Artifrin with drugs metabolized in the liver may affect their metabolism and increase the risk of toxic effects.