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Sialor nasal spray.
Last reviewed: 26.07.2024
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By its local action Sialor spray from runny nose is a disinfectant (antiseptic) agent of bacteriostatic nature. According to its therapeutic use, it is classified as a category of other means for the treatment of diseases of the nasal cavity.
Indications Sialora
This remedy is used to treat:
- purulent rhinitis;
- Acute, chronic or recurrent nasopharyngitis of bacterial origin;
- purulent rhinosinusitis;
- complications of viral rhinitis in the form of bacterial chronic sinusitis;
- runny nose at inflamed adenoids.
Release form
One package of Sialor spray contains a set of 10 tablets (200 mg each) for preparation of solution and solvent.
Pharmacodynamics
The active ingredient in this runny nose medicine is Protargol (silver proteinate), which is silver colloidal solution oxide (argentum colloidale) or collargol containing silver nanoparticles (AgNP).
AgNPs have a bacteriostatic effect due to the release of biologically active silver ions (Ag+), which bind to proteins of bacterial cell membranes (in particular, Staphylococcus aureus, Streptococcus pyogenes and Escherichia coli) and penetrate into their cytoplasm. Free positively charged silver ions block respiratory enzymes of bacteria, which leads to oxidative stress and interruption of ATP release, as well as inactivation of nucleic acids of the bacterial genome, which significantly reduces their reproduction.
The alleged anti-inflammatory effect of silver proteinate is explained by the fact that a film of silver-precipitated proteins is formed on the mucous membrane lining the nasal cavity. This narrows mucosal vessels in the nasal and paranasal cavities and reduces their sensitivity to signaling proinflammatory proteins.
Pharmacokinetics
Used topically Protargol does not enter the systemic bloodstream and does not have a systemic effect.
Dosing and administration
2% solution for intranasal administration is prepared by dissolving one tablet (200 mg) in 10 ml of solvent. The ready solution is applied by 1-2 injections into each nasal passage - after their preliminary cleaning from mucous secretions - up to three times during the day. Duration of use - 5-7 days.
Application for children
Manufacturers of sprays with protargol differently interpret the possibility of their use in children, and Sialor spray is recommended for children from birth, although in pediatric ENT practice, the use of drugs in aerosol form is contraindicated until the age of three years due to the age-related characteristics of the nasal passages (drops are used to treat rhinitis during the first three years of life).
Use Sialora during pregnancy
Sialor spray is contraindicated to take in pregnancy and lactation.
Contraindications
Hypersensitivity to Protargol.
Side effects Sialora
Protargol Spray may cause dryness of the nasopharyngeal mucous membranes or an allergic reaction manifested by burning and itching. Headache and/or dizziness may also occur.
In case of frequent inhalation of silver proteinate, the possibility of accumulation of silver nanoparticles in mucous tissues with their irritation cannot be excluded.
Overdose
Exceeding the dosage of Protargol or prolonged use of preparations containing silver proteinate may lead to local cyanosis and skin discoloration.
Interactions with other drugs
Protargol is incompatible with mineral and organic acids, hydrogen peroxide, ammonia.
Storage conditions
The drug should be stored in the original package in a place protected from light at a temperature not exceeding +25°C. Prepared solution is stored in the refrigerator for not more than two weeks.
Shelf life
24 months.
Analogs
Given the bacteriostatic effect of Protargol, sprays with the antibiotic framycetin Isofra (Sofradoxa) can be considered analogs of Sialor.
In addition, trade names for colloidal silver sprays include: Noxprey Silver; Protargol and Protargol Baby (powder for preparing a solution to be injected into the nose); Silvelor sprays (which contains colloidal silver, eucalyptus and kalanchoe extract, aloe vera gel, dexpanthenol, vitamin A and E); Deflu Silver (with colloidal silver, Icelandic moss extract, dexpanthenol, vitamins E and A) and its synonym Sinumix Aqua Plus.
Attention!
To simplify the perception of information, this instruction for use of the drug " Sialor nasal spray." translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.