Suppositories from cystitis: antibacterial, anti-inflammatory, analgesic

Suppositories from cystitis - the most common urological disease - are an auxiliary means of treating this pathology, although the medicinal substances included in their composition can sometimes be absorbed faster than with oral administration of pharmacological agents similar in effect.

[1], [2], [3], [4], [5], [6],

Indications for use

Indications for the use of suppositories from cystitis include such symptoms of inflammation of the lower urinary tract as frequent urination with a small volume of intensely stained urine, burning with urination, often acute or pulling pains in the lower abdomen, general weakness and chills.

Names of suppositories from cystitis

An exemplary list containing the names of suppositories from cystitis can be made on the basis of preparations of this form, which are recommended by doctors most often. These are vaginal suppositories with cystitis Hexicon, suppository with palin, suppository with sintomycin, suppositories of Genferon, Betadine, Macmiore, and rectal suppository for cystitis: Diclofenac, Voltaren, Indomethacin, suppository with methyluracil.

It should be borne in mind that sexually transmitted infections (Chlamydia, Trichomonas, Gardnerella, Treponema, Ureaplasma, etc.) have a negative effect on both the lower urinary tract in women and the urethra in men, and show the same symptoms , as with cystitis. In women, cystitis often occurs against bacterial vaginosis, ureaplasmosis or thrush. In men, cystitis is often diagnosed as urethritis. In addition, inflammation of the prostate gland (prostatitis) also has similar signs, so this list includes not only a suppository for cystitis in women, but also some anti-inflammatory and anesthetic candles used in male urology. Their form of release is suppositories for rectal administration.

In the drug therapy of cystitis with the help of suppositories antibacterial, anti-inflammatory and analgesic suppositories are used; some of them combine anti-inflammatory and analgesic properties.

Antibacterial suppository for cystitis

Since most often the etiology of this disease is bacterial (and its main pathogens are Escherichia coli E. Coli and Staphylococcus saprophyticus), it is necessary to use antibacterial suppositories for cystitis: Hexicon, suppository with palin, Betadine, Macmirror, sintomycin suppositories.

Pharmacodynamics of suppositories from cystitis Hexicon is provided by the active antiseptic chlorhexidine bigluconate (0.016 g in one suppository), which has bactericidal properties. The combination of chlorhexidine with phosphates on the cell membranes of bacteria, trichomonads and the Herpes simplex virus leads to their death, and on Candida fungi, the hexicon acts as a fungicide.

Suppositories Gexicon in cystitis, as indicated in the instructions, are intended for the therapy of vaginitis (including trichomoniasis), inflammation of the cervix of various origin, as well as to prevent infection with sexually transmitted infections. The use of these suppositories during pregnancy is possible in all trimesters. Minor side effects of suppositories from cystitis Hexicon can be manifested in the form of itching.

The recommended way of administration and dose is the introduction into the vagina of one suppository once or twice a day for a week. However, according to the official instruction, 0.2% aqueous (sterile) chlorhexidine solution is used in the treatment of cystitis - for washing the bladder.

Suppositories with Palin in cystitis (synonym - Urosept) can also be used for acute pyelonephritis and urethritis in cases where pathogens are susceptible to the action of this uroseptic. The pharmacodynamics of these suppositories is due to the pipemidic acid that enters them, which blocks the activity of the enzyme system of pathogenic microorganisms and thereby disrupts the process of their multiplication. Suppositories do not work in the presence of cystitis against the background of a lesion of the urogenital sphere with Trichomonas, Mycoplasma, Chlamydia and Candida fungi.

Contraindications to the use of suppositories from cystitis with Palin include renal and hepatic dysfunction, CNS pathology and pregnancy. The usual dosage - one suppository intravaginally (at night) for a week, while the simultaneous intake of Palin capsules is recommended (with an increase in the volume of fluid used). This drug (in any form) can cause nausea, vomiting, diarrhea, rashes on the skin and its increased sensitivity to ultraviolet light, headache, vision problems. According to many experts, the appointment of Palin - in the presence of more effective drugs - yesterday's day of urology.

The main component that contains the suppository Betadine for cystitis is povidone-iodine (200 mg in each suppository). Thanks to iodine, the action of suppositories of Betadin is simultaneously antiseptic, disinfectant, bactericidal, antifungal and antiviral. Iodine oxidizes the amino acids of enzymes of microorganisms and coagulates their proteins, which leads to the death of pathogens. And, the resistance of microorganisms to povidone-iodine does not develop even with prolonged use of the drug. Betadin suppositories are prescribed in gynecology with candidiasis, trichomoniasis, vaginitis, bacterial vaginosis, as well as lesions of the mucous membranes of the vagina with chlamydia, urea- and mycoplasma, the herpes virus and papillomavirus. Suppositories are administered intravaginally at night - one per day; the course of treatment lasts one to two weeks (depending on the intensity of inflammation).

With thyroid disease, cardiac or renal insufficiency, the suppositories of betadine are contraindicated. The use of suppositories from cystitis during pregnancy - due to iodine content - is unacceptable in the first three months.

In the case of Betadine, the interaction of suppositories with cystitis with other drugs is incompatible with all other antiseptics, which contain alkalis, oxidants or metal salts. And an overdose of povidone-iodine can lead to the appearance in the mouth of a metallic taste and increased salivation, as well as to diarrhea, edema (including lungs) and dyspnea.

Synthomycin suppository for cystitis is used in gynecological practice for lesions of the pelvic organs with staphylococci, streptococci, Escherichia coli, shigella, chlamydia, Klebsiella sticks, proteus and other Gram-positive and Gram-negative bacteria. Recommended introduction to the vagina on one suppository twice a day for 7-10 days.

The mechanism of pharmacological action of suppositories with antibiotic sintomycin (isomer of levomycetin) is based on the fact that the active substance of the preparation damages the protein synthesizing ribosomes of bacteria. The pharmacokinetics of suppositories from cystitis based on synthomycin differs in almost complete absence of their systemic action. However, it does not exclude the possibility of side effects in the form of allergic reactions and oppression of the functions of the hematopoiesis system. Therefore, in pathologies of the bone marrow, porphyrin disease, and during pregnancy, these suppositories are contraindicated.

The instruction notes that simultaneous use of synthomycin suppositories with antibiotics such as penicillin, erythromycin, clindamycin, the therapeutic effect of all drugs is significantly reduced. Also, the protective effect of oral contraceptive means is neutralized.

When infection and inflammation of the urinary tract are prescribed suppository Macmirror. In addition to cystitis and urethritis, indications for the use of suppositories from McMirror cystitis include a wide range of vulvovaginal infectious lesions. These suppositories have both antibacterial properties (due to the presence in their composition of nitrofuran antibiotic nifuratel), and antifungal (provided by highly active drug nystatin). Nifuratel blocks cellular respiration and the synthesis of bacterial nucleic acids, and nystatin, built into the cells of pathogenic fungi, disrupts the balance of cations and anions in their cytoplasm. In this case, nifuratel increases the effectiveness of nystatin relative to fungi of the genus Candida. These vaginal suppositories for cystitis should be used for at least a week - one suppository a day (injected overnight). Pregnant women this drug is contraindicated.

[7]

Anti-inflammatory suppository for cystitis

In clinical urology, anti-inflammatory suppositories for cystitis are used for symptomatic treatment.

They help repair damaged mucous membranes of the urinary bladder and urinary tracts of methyluracil suppository in cystitis, which stimulate the formation of erythrocytes and leukocytes, normalize intracellular metabolism and thereby accelerate the proliferation of new cells. Among the contraindications to the use of suppositories with methyluracil, there are myeloid leukemia, lymphogranulomatosis and pathologies of malignant bone marrow. And among the side effects - a rapid burning sensation in the rectum. The way of applying these suppositories is rectal, the dose is one suppository three times a day, the duration of treatment is determined by the doctor.

Diclofenac suppository for cystitis (synonyms - Naklofen, Dicloberl, Voltaren) refer to non-steroidal anti-inflammatory drugs (NSAIDs). Pharmacodynamics of suppositories from cystitis with NSAIDs is associated with the blocking of production in the inflammatory focus of prostaglandins, which carry painful, inflammatory and thermal signals from receptors to the corresponding regions of the brain.

The pharmacokinetics of suppositories from cystitis with diclofenac sodium has the same bioavailability and metabolism characteristics as internal NSAIDs, but the maximum concentration in the blood plasma is observed in half an hour, and when using the tablet form of the drug - after almost two. From the blood, diclofenac is excreted completely after about 4 hours, from the body metabolites are eliminated by the kidneys.

Suppositories Diclofenac are effective for pain and inflammatory processes of any tissues, including mucous membranes of the bladder. They should be injected into the rectum - one suppository twice a day, the maximum allowable daily dose of 150 mg (three suppositories of 50 mg), and the duration of application should not exceed 7 days.

Contraindications to the use of suppositories against cystitis Diclofenac (as well as other suppositories with NSAIDs): intolerance to aspirin; bronchial asthma; ulcer and inflammatory diseases of the digestive tract; severe forms of renal, hepatic and cardiac failure. During pregnancy, the use of suppositories from cystitis with NSAIDs is possible (with caution and under the supervision of a doctor) in the first and second trimester, in the last three months - it is contraindicated.

Side effects of suppositories from cystitis Diclofenac include abdominal pain, nausea and vomiting, diarrhea and flatulence, headache and dizziness, decreased or increased blood pressure, skin rash. Overdose can lead to increased side effects, as well as gastric bleeding and convulsions.

Particular attention should be paid to the interaction of suppositories from cystitis with other drugs. Diclofenac and all NSAIDs can not be used together with Paracetamol, Methotrexate and cyclosporins (due to nephrotoxic effects), with anticoagulants and antithrombotic agents (there is a threat of gastric bleeding), as well as with diuretics (hyperkalemia may develop). Also, these suppositories can not be used together with Palin and all quinolone antibiotics in connection with the likelihood of seizures.

Voltaren suppository with cystitis have diclofenac as an active ingredient. Used rectally, similar to the described suppositories Diclofenac.

Indomethacin suppository for cystitis with an active substance based on indoleacetic acid also belongs to the pharmacological group of non-steroidal anti-inflammatory drugs, and therefore all the main characteristics, including contraindications, and the use of suppositories against cystitis during pregnancy, are identical to those of Diclofenac suppositories.

In addition, doctors recommend for acute and chronic cystitis suppository with propolis. Due to two hundreds of natural nutrients that make up the bee glue, the damaged mucous membranes of the bladder and urinary tracts heal well. Suppositories are applied vaginally - 1-2 times a day, the course of treatment is 5-7 days. But those who have an allergy to honey and bee products these suppositories do not fit.

[8], [9], [10], [11]

Anesthetic suppository for cystitis

Pain in inflammation of the bladder removes the already mentioned above rectal suppository for cystitis Diclofenac, Voltaren, Indomethacin.

Also introduced rectally Papaverina suppository for cystitis (0.02 g) - twice a day, one suppository. These suppositories contain the papaverine hydrochloride alkaloid, which is myotropic antispasmodic, and the weakening of the tone of the muscle tissue of the bladder leads to the cessation of pain. With increased intraocular pressure (glaucoma), atherosclerosis (especially in adulthood), tachycardia and kidney or liver deficiency, papaverine is contraindicated.

Side effects of suppositories from cystitis with papaverine are manifested by reddening of the skin, nausea, dizziness, cardiac extrasystole, constipation. In case of an overdose, there is a decrease in blood pressure, weakness, drowsiness, double vision.

Genferon suppository for cystitis has in its composition human recombinant interferon alpha, sulfur-containing amino acid taurine and anesthetic benzocaine. According to the information given in the instructions for this drug, the suppository has immunomodulating, antibacterial and anesthetic properties. For the first two useful actions, interferon, which stimulates intracellular enzymes, and taurine, activates interstitial biochemical processes and improves healing of damaged tissues. A local anesthetic effect provides benzocaine (ethyl-4-aminobenzoate), which blocks nerve signals, changing the ionic potential of the cellular membranes of pain receptors.

Contraindications to the use of suppressory geneferon are pregnancy in the first trimester, acute allergic conditions and autoimmune diseases. Therapy with this medication can be accompanied by headache and muscle pain, fever, sweating, tiredness and weakness.

Dosage and administration: Suppository Genferon is applied vaginally or rectally at one suppository two times a day for 10 days.

And the prices of suppositories from cystitis - for packing 10 pieces - the most different. So, suppositories Geksicon stand on average 150-160 UAH., Betadin - 210-215 UAH., Voltaren - from 60 UAH., Methyluracil suppository and Diclofenac - 16-20 UAH.

[12], [13], [14]

Storage conditions

Obviously, it is useful to know that the conditions for storage of suppositories from cystitis assume the absence of light and moisture, as well as the corresponding temperature regime. For storage of methyluracil and sintomycin suppositories, suppositories with palin and also suppositories of Genferon, Geksicon, Macmirror, Diclofenac, etc., the temperature should not be higher than + 20-25 ° C. Suppositories Betadine should be stored at a temperature of + 10-15 ° C.

Shelf life

The shelf life of most suppositories is limited to two years, the Palin suppository can be used for five years after release.

Reviews

Reviews of suppositories for cystitis are also different, because their effectiveness largely depends on how much their purpose takes into account the cause of the disease. So the best suppository for cystitis is those that will help in treatment with the least side effects and in the shortest possible time - with the right combination with medications for internal use recommended by the doctor.