Macmiror

One of the most effective antimicrobial and disinfectant drugs, which are used, including in gynecology, is considered to be Macmiror.

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Indications Macmirora

The drug Macmiror can be used to treat:

• vulvovaginal infectious pathologies caused by pathogenic microbes, fungi, chlamydia, trichomonas, etc.;
• diseases of the urinary tract (inflammatory processes in the bladder, urethra, kidneys);
• intestinal giardiasis and amebiasis.

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Release form

Macmiror is produced in the form of convex tablets covered with a soluble protective shell.

The active ingredient of the medication is nifuratel, the content of which in one tablet is 0.2 g.

The tablets are packed in blister packs of 10 tablets.

The cardboard box contains two blister plates.

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Pharmacodynamics

The active ingredient of the drug Macmiror is the nitrofuran drug nifuratel.

Studies have confirmed the extensive antimicrobial action of nifuratel, which is especially evident in infectious lesions of the urinary and reproductive systems. The principle of action of the drug has not been thoroughly studied. However, it has been determined that Macmiror has a metabolic effect on enzymes that promote the development and growth of bacteria. The drug has a similar effect on trichomonas.

Macmiror can be used as an antimicrobial agent to affect gram (+) and gram (-) aerobes and anaerobes. The lowest effective dosage can be from 2.5 to 5 mcg per ml.

Macmiror has a strong inhibitory effect on chlamydia and a weaker effect on ureaplasma and mycoplasma. The antifungal effect is less noticeable when compared with Ketoconazole or Flutrimazole.

The extensive antimicrobial effect of Macmiror allows it to be used for any infections of the genital and urinary organs. At the same time, nifuratel does not suppress lactobacilli, which are part of the natural composition of high-quality bacterial flora: due to this, recovery from vaginal inflammatory pathologies is accelerated, and re-infection is excluded.

The drug demonstrates a good effect in the treatment of patients with intestinal diseases - amebiasis or giardiasis. There is also information about the significant antiprotozoal ability of Macmiror.

Macmiror does not lead to the development of cross-resistance of bacteria to other antimicrobial drugs.

Pharmacokinetics

After oral administration of 0.2 g, Macmiror is rapidly absorbed in the digestive tract. The level of the active ingredient in blood plasma 120 minutes after administration was about 9.48 mcg per ml.

The active substance is quickly distributed throughout all tissues in the body. The half-life can be approximately 2.75 hours.

About half a percent of the active ingredient is excreted unchanged in urine. The rest leaves the body in the form of residual metabolic products.

Nifuratel, the active ingredient, was not detected in intrahepatic circulation.

Dosing and administration

• Infectious pathologies of the genital organs.

Adults are recommended to take 1 tablet of Macmiror three times a day after meals for a week. It is advisable to conduct simultaneous treatment for the patient and her sexual partner. Additionally, intravaginal capsules and/or Macmiror cream can be used.

In some cases, 4 tablets may be prescribed daily. It is better to stop sexual intercourse during the therapeutic course.

In childhood, starting from 10 years, Macmiror is prescribed in the amount of 10 mg per kilogram of weight daily, dividing the dosage into two doses. The duration of the course in this case will be about 10 days.

• Infectious diseases of the urinary system.

Adults are prescribed three to six Macmiror tablets daily (0.2-0.4 g per day) after meals. Duration of therapy is about 7-14 days.

In childhood, starting from the age of six, Macmiror can be prescribed in the amount of 10 to 20 mg per kilogram of weight per day (in two doses). The course of therapy is 7-14 days.

If necessary, treatment may be longer.

• Intestinal amebiasis.

Adults are prescribed 2 Macmiror tablets three times a day, after meals, for ten days.

In childhood, starting from the age of six, it is appropriate to prescribe a daily dosage of 30 mg per kilogram of weight. The total amount of the drug is divided into three doses. The course of therapy is 10 days.

• Giardiasis of the intestines.

Adults take 2 Macmiror tablets up to 3 times a day, after meals. Duration of treatment is one week.

Children from the age of six take the medicine at a rate of 30 mg per kilogram of weight, dividing the dosage into two doses. The course duration is one week.

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Use Macmirora during pregnancy

Read about the specifics of using Macmiror for treating pregnant and lactating patients in this article.

Contraindications

Macmiror should not be used:

• in case of hypersensitivity to the drug;
• in case of severe kidney pathologies;
• for neuropathy;
• with a lack of glucose-6-phosphate dehydrogenase;
• children under six years of age;
• women throughout the entire period of bearing and breastfeeding a baby.

Side effects Macmirora

Among the few side effects that may occur most frequently are:

• eating disorders;
• attacks of nausea, diarrhea, a feeling of bitterness in the mouth;
• vomit;
• skin problems, itchy urticaria;
• peripheral neuropathies.

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Overdose

To date, there have been no recorded cases of patients overdosing on Macmiror.

Interactions with other drugs

There are no clinically significant interactions between the medicinal product Macmiror and other medications.

It is known that the simultaneous use of alcoholic beverages can provoke the development of disulfiram-like syndrome, which is manifested by chest pain, reddening of the skin, increased heart rate, nausea, and reflex cough.

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Storage conditions

It is recommended to store Macmiror in rooms with a temperature regime from +18 to +25°C, away from children. The storage place should be dry and located at some distance from sources of bright light and heat.

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Shelf life

Macmiror can be stored for up to 5 years.