Macmiror complex suppositories in the 1st, 2nd and 3rd trimester of pregnancy: features of application

Various infections in pregnant women develop quite often. And the reason for this is, first of all, the weakening of the body's immune defense. Of course, any infection needs to be treated, and often one of the drugs that a doctor can prescribe is Macmiror.

If you believe the instructions for the medication, Macmiror is prohibited during pregnancy. However, it is still prescribed. Therefore, a predictable question arises: is this drug safe?

Indications macmiror in pregnancy

When the hormonal balance is rebuilt, the woman's immune defense weakens significantly. And this is considered normal for the quality development of pregnancy. However, at the same time, such processes can lead to the addition of an infection and the development of inflammatory reactions. And this is very dangerous, especially during pregnancy.

Infections, in turn, can cause complications. To prevent this from happening, in many cases, the use of medications like Macmiror is entirely justified.

Macmiror may be useful during pregnancy:

• for infectious vulvovaginitis (candidiasis, trichomoniasis, chlamydia);
• in infectious lesions of the urinary system;
• in case of intestinal amebiasis or giardiasis;
• in case of damage to the digestive tract by Helicobacter.

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Release form

Macmiror is available in tablet form (enteric-coated tablets of 200 mg). The packaging consists of two blister strips with 10 tablets in each strip.

However, during pregnancy, the drug Macmiror complex is mainly prescribed, which is produced in such medicinal forms as intravaginal suppositories or vaginal cream.

Macmiror tablets contain the active ingredient nifuratel.

Macmiror complex is a combination of two active ingredients: nifuratel and nystatin.

Macmiror suppositories are the most relevant during pregnancy. Each suppository contains 500 mg of the nitrofuran component nifuratel, while the cream contains 100 mg of nifuratel per 1 g of the drug.

Macmiror complex is used during pregnancy in the second half. The active ingredient nifuratel and the antifungal component nystatin enhance each other's action and provide the fastest possible therapeutic effect.

Pharmacodynamics

Macmiror during pregnancy has a pronounced antifungal and antimicrobial effect, so it is very convenient to use for the treatment of mixed infections.

Nifuratel is a representative of nitrofuran drugs, which is capable of disrupting cellular respiratory processes in microorganisms. As a result, pathogenic microorganisms die.

Nifuratel has a complex structure. It has a nitro group that can be reduced inside the cellular structure, providing a cytotoxic effect.

Nifuratel is active against aerobes and fungi. This component of Macmiror suppresses the production of nucleic acids: as a result, the DNA of pathogenic organisms is not duplicated, and the reproduction process is disrupted.

Nystatin potentiates the effect of the main ingredient Macmiror. This is an antifungal substance that removes the protection of pathogenic cells, causing these cells to die.

Nystatin is one of the low-toxic drugs with selective antifungal action, so its use does not lead to the development of vaginal dysbacteriosis.

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Pharmacokinetics

Macmiror in tablet form is well absorbed in the digestive tract and easily overcomes the blood-brain and placental barriers, accumulating in the liver and muscles. The components are completely eliminated from the body, exerting a powerful anti-infective effect on the urinary system.

Macmiror complex does not have a systemic effect when applied locally intravaginally, since it is not absorbed from the mucous surface. In addition, the drug is not able to be absorbed through the skin when applied externally. That is why the use of Macmiror in the form of suppositories or cream during pregnancy is more preferable.

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Dosing and administration

For intravaginal infections, take 1 tablet of Macmiror in the morning, afternoon and evening after meals for one week.

For pyelonephritis and other infectious lesions of the urinary system, take 1-2 tablets of Macmiror three times a day. The course lasts 1-2 weeks.

For intestinal infections, 2 tablets of Macmiror are prescribed up to 3 times a day (course – from 7 to 10 days).

In case of gastrointestinal tract infection by Helicobacter pylori, 2 tablets of Macmiror are prescribed up to 3 times a day for a week.

• It is better not to use Macmiror during pregnancy in the first trimester, as it may pose a danger to the development of the fetus.
• Macmiror is used during pregnancy in the 2nd trimester mainly intravaginally: one suppository is inserted daily at night for eight days in a row (unless the doctor prescribes another treatment regimen). To ensure that Macmiror is as effective as possible, the suppository is inserted deep into the vaginal cavity.
• Macmiror during pregnancy in the 3rd trimester is allowed to be used in different dosage forms. However, the drug is prescribed only when absolutely necessary, after carefully weighing the benefits and harms of using the medication.

Contraindications

Macmiror is not used during pregnancy if the woman has a tendency to hypersensitivity - either to the active ingredient or to other components of the medication.

Other contraindications include:

• neuropathies;
• glucose-6-phosphate dehydrogenase deficiency.

During pregnancy, Macmiror should not be used for prophylaxis, or if this drug can be replaced by another, safer medication.

The decision to prescribe Macmiror during pregnancy is made only by a medical specialist.

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Side effects macmiror in pregnancy

Taking Macmiror tablets during pregnancy can cause nausea, a bitter taste in the mouth, diarrhea, as well as hypersensitivity reactions and peripheral neuropathies.

Local application of Macmiror in some cases leads to allergies in the form of skin rashes, redness and a burning sensation.

If any side effects occur during pregnancy, the use of Macmiror should be discontinued.

Overdose

Up to now, there have been no reports of Macmiror overdose during pregnancy. However, you should stick to the dosages recommended by your doctor.

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Interactions with other drugs

Experts have not found any clinically significant interactions of Macmiror with other medications and substances.

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Storage conditions

Macmiror tablets can be stored in normal room conditions, away from children.

For storing candles and cream, it is recommended to choose a cool place where sunlight does not reach.

Shelf life

The tablets can be stored for five years.

Candles and cream are good for up to three years.

Reviews

During pregnancy, Macmiror in tablet form is most often prescribed to women if they have an inflammatory process in the kidneys or urinary tract. However, tablets are taken with great caution during pregnancy, excluding the first trimester - at this stage, the most basic organ systems of the baby are formed, so it is easy to harm him.

For vulvovaginitis, chlamydia, trichomoniasis, candidiasis and mixed infectious pathologies, Macmiror is used for local therapy, that is, in the form of suppositories or cream.

Judging by numerous reviews, Macmiror is a fairly effective and powerful therapeutic drug, which many doctors are afraid to use during pregnancy. And there is an explanation for this: the active components of Macmiror easily enter the bloodstream of the unborn child, so they are theoretically capable of harming him. In order to protect yourself and your child from unwanted consequences, you cannot "prescribe" the drug to yourself. Macmiror will not cause harm during pregnancy if it is prescribed by a doctor, and the treatment is carried out under his constant supervision.