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Health

List Analyzes – T

1 5 A B C D E F G H I L M N O P R S T U V W Y
The study of fractions of lipoproteins in clinical practice is used to typify dyslipoproteinemia. Dyslipoproteinemia - deviations in the lipoprotein spectrum of the blood, manifested in a change in the content (increase, decrease, absence or disruption of the ratio) of one or more classes of lipoproteins.
Bladder antigen (BTA) detection in the urine is a screening method for diagnosing bladder cancer, as well as for dynamic monitoring of patients after surgical treatment. Antigens are detected in 70-80% of patients with bladder cancer in stage T1-T3 and in 58% with cancer in situ.
ELISA is a more sensitive and specific method of diagnosing tularemia, it allows detecting antibodies of classes IgA, IgM and IgG. Detection of IgM antibodies or a 4-fold increase in the IgG titer confirms an acute infection or reinfection with an appropriate clinical picture of the disease.
In contrast to serological methods for diagnosing tuberculosis infection, detecting antibodies to mycobacteria of tuberculosis, PCR makes it possible to directly detect the DNA of mycobacterium tuberculosis and quantitatively express their concentration in the test material.
Determination of antibodies to the causative agent of tuberculosis in serum is a new and very promising method for the serological diagnosis of tuberculosis. The currently used bacteriological method for isolating the mycobacterium of tuberculosis requires considerable time-consuming (4 to 8 weeks) and is very effective mainly in the pulmonary forms of tuberculosis.
The troponin complex is part of the contractile system of muscles. It is formed by three proteins: troponin T, which forms a link to tropomyosin (molecular weight 3700), troponin I (molecular weight 26,500), which can inhibit ATPase activity, and troponin C (molecular weight 18,000), which has a significant affinity for Ca2 + .
Troponin I is a structural protein of the troponin complex of muscles with a molecular weight of 26,500 Da. Troponins I, like troponins T, cardiac and skeletal muscles, differ significantly in their amino acid sequence.
Triglycerides, or neutral fats, are esters of a trihydric alcohol of glycerin and higher fatty acids. Triglycerides enter the body with food (exogenous triglycerides) and are synthesized in the body (endogenous triglycerides).

For early serological diagnosis of trichinosis, the definition of IgG antibodies using the ELISA method is used. The sensitivity of the ELISA is 90-100%, the specificity is 70-80%. Specific antibodies appear in the blood of infected Trichinella larvae and their concentration in muscles during the migration period.

Transferrin refers to beta-globulins. The main function of transferrin is transport of absorbed iron into its depot (liver, spleen), into reticulocytes and their precursors in the red bone marrow. Transferrin is able to bind ions of other metals (zinc, cobalt, etc.).
Early diagnosis of toxoplasmosis is especially important for pregnant women due to the risk of intrauterine infection of the fetus, which can lead to fetal death (spontaneous abortion) or the birth of a child with serious lesions.
The main method of diagnostics of toxocarosis is the detection of IgG antibodies to Toxocara canis in the serum by ELISA with toxocar antigen in the study of blood serum in persons with a characteristic complex of symptoms: lymphadenopathy, hepatomegaly, bronchitis, bronchial asthma of unclear origin, urticaria rash against the background of eosinophilia of blood, leukemoid reaction eosinophilic type with a characteristic epidemic history (for example: geophagia), etc.

Toxicological studies play a crucial role in the diagnosis of various poisoning. When conducting specific toxicological studies, it is very important to obtain the results of the assays as soon as possible (1-2 hours).

T3 (triiodothyronine) is formed and synthesized by the thyroid gland, but the bulk of T3 is formed outside the thyroid gland when deaoding T4. Approximately 99.5% of T3 circulating in the blood is bound to proteins. The half-life of blood is 24-36 hours. The activity of T3 is 3-5 times higher than that of T4.
T4 (thyroxine) - the main hormone of the thyroid gland. Its concentration in the blood exceeds that of T3 by 60 times. The elimination half-life is 5-7 days.
The concentration of total protein in the serum depends mainly on the synthesis and decomposition of the two main albuminous fractions, albumin and globulins.
The total iron-binding capacity of blood serum is the indicator of transferrin concentration. It should be taken into account that when evaluating the content of transferrin according to the results of determining the total iron binding capacity of blood serum, it is overestimated by 16-20%, since at more than half saturation of transferrin, iron binds to other proteins.
Creatine kinase reversibly catalyzes the phosphorylation of creatine. The most rich in creatine kinase is skeletal musculature, the heart muscle, less in the brain, thyroid gland, uterus, lungs.
Cholesterol is a secondary monohydric cyclic alcohol. Cholesterol enters the body with food, but most of it is formed endogenously (synthesized in the liver). Cholesterol is a component of cell membranes, a precursor of steroid hormones and bile acids.
In metabolic equilibrium, the daily excretion of calcium in the urine corresponds to the absorption of calcium in the intestine. Calcium excretion in the urine depends on the amount of filtered calcium in the glomeruli and tubular reabsorption. Filtration in the glomeruli of ionized calcium and calcium in a complex with low-molecular anions (approximately 60% of the total in the blood serum).

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