Baralgetas

Renalgan is a complex medicine, whose therapeutic activity is provided by the properties of its three main constituent components. The medicine has a strong antispasmodic and analgesic effect.

Metamizole Na demonstrates analgesic, antipyretic, and in addition anti-inflammatory (mild) effect.

The pitofenone component promotes relaxation of smooth muscles in the area of internal organs. [1]

The element fenpiverinium also demonstrates noticeable antispasmodic activity. [2]

Indications Renalgan

It is used for such disorders:

• pains of different intensity and nature;
• spasms in the musculature of the internal organs (biliary colic or colic in the intestines / kidneys, as well as spasms affecting the ureter and bladder) or  algomenorrhea .

It is prescribed to eliminate the symptoms of neuralgia , sciatica, myalgia or arthralgia, as well as to relieve pain that appears after operations.

Release form

The drug is produced in tablets - inside the cell plate, 10 pieces each.

It is also sold in the form of a liquid for intramuscular and intravenous injections - inside ampoules with a capacity of 5 ml. The pack contains 5 such ampoules.

Pharmacokinetics

After an intramuscular injection, the drug is absorbed at high speed. Bioavailability values are approximately 85%. Blood Cmax values are noted after 60 minutes on average.

The synthesis of metamizole with blood protein is 50-60%; the substance overcomes the BBB and the placenta without complications. The drug undergoes intensive intrahepatic transformation; its metabolic elements have medicinal activity.

Excretion mostly takes place through the kidneys, in the form of metabolic components.

Dosing and administration

Ampoules of the drug should be injected intramuscularly - 2-5 ml of liquid, repeating the procedure at 7-8-hour intervals. A maximum of 10 ml of the substance is allowed to be administered per day. The parenteral regimen can last 2-3 days, and then the patient is transferred to taking pills.

Adults and children from 12 years old can take 1-2 tablets 1 time. It is recommended to take it after eating. A maximum of 3 servings of the drug can be administered per day. Receptions are carried out with 6-8 hour breaks. A maximum of 6 tablets are allowed per day. Oral administration is often prescribed after therapy with Renalgan injections.

• Application for children

Not assigned to persons under 5 years of age.

Use Renalgan during pregnancy

It is forbidden to administer the medicine during pregnancy.

Contraindications

The main contraindications:

• severe intolerance to the medication;
• blood pathologies;
• Heart failure or ischemic heart disease;
• tachycardia;
• diseases affecting the kidney / liver;
• angle-closure glaucoma;
• BPH;
• breast-feeding.

Caution is required for such violations:

• failure of liver / kidney function;
• strong sensitivity to NSAIDs;
• BA;
• reduced blood pressure values;
• urticaria associated with the use of other NSAIDs or aspirin.

Side effects Renalgan

When given in the recommended dosages, Renalgan is often tolerated without complications. Only occasionally do local symptoms of allergy appear (epidermal rash and itching), headaches, xerostomia, tachycardia, gastric burning, dizziness, hypohidrosis and a decrease in blood pressure values.

In case of exceeding the dosage or prolonged use, thrombocyto- or leukopenia, agranulocytosis and fever, as well as sore throat, chills and stomatitis may appear.

Overdose

With intoxication, the following signs appear: disorders of the gastrointestinal tract (among them xerostomia, nausea, stomach pain and vomiting), toxic-allergic symptoms and signs of damage to the hematopoietic organs with the brain. In addition, there is accommodative disorder, impaired renal function, drowsiness, decreased blood pressure values, convulsions and confusion.

Interactions with other drugs

The introduction of a medication together with substances that suppress the activity of the central nervous system, and alcohol can cause a disorder of psychomotor activity (drowsiness).

The combination of drugs and non-narcotic analgesics mutually potentiates their toxic properties.

The use of the drug simultaneously with chlorpromazine leads to the appearance of intense hyperthermia.

Penicillin, X-ray contrast agents and colloidal type blood substitutes should not be used in Renalgan therapy.

Tranquilizers and sedatives potentiate the analgesic effect of the medication.

The toxic activity of drugs is potentiated when administered in combination with antidepressants and oral contraception.

Phenylbutazone weakens the therapeutic effect of the drug.

Storage conditions

Renalgan must be stored at temperatures in the range of 8-15 ° C.

Shelf life

Renalgan can be used for a 24-month term from the date of manufacture of the pharmaceutical product.

Analogs

The analogues of drugs are the substances Maxigan, Spazmoblok, Baralgetas, Reonalgon with Baalgin, Spazmadol and Baralginus with Spazgan, and besides this Realgin, Trinalgin, Spazmalgon, etc.

Reviews

Renalgan receives mostly positive feedback from its patients. In the comments, a pronounced medicinal effect of the drug is noted - especially when performing injections in case of colic in the intestinal or kidney area, headaches or toothaches, as well as after operations.