Vagikal

Phytopreparation Vagikal belongs to the pharmacological group of antimicrobial and antiparasitic medicines of natural origin. Intended for use in gynecology.

Indications Vagikal

In gynecological practice, the vaginal suppository Vagikal can be used for local symptomatic treatment as part of the complex therapy of nonspecific inflammations of the vagina and vulva caused by opportunistic microorganisms (escherichia, enterococcus, corynebacterium, streptococcus, staphylococcus, etc.). For the pathological processes of this etiology is characterized by the presence of vaginal discharge, often accompanied by itching in the vestibule of the vagina, a burning sensation and a sense of heaviness in the genital area.

The diseases that show the use of Vagikal include: nonspecific vaginitis (colpitis), atrophic colpitis (in women during menopause), nonspecific bacterial vaginosis.

This phytopreparation can be used in the complex treatment of candidiasis and trichomonas vaginitis, and also as an auxiliary anti-inflammatory agent in the erosion of the cervix.

[1], [2], [3], [4]

Release form

The form of the drug Vagikal - suppositories vaginal, one suppository contains 150 mg of extract of the active substance.

[5], [6], [7]

Pharmacodynamics

The active substance of phytopreparation Vagikal - Calendula officinalis (Calendula officinalis). Due to its chemical composition, this medicinal plant has antibacterial and anti-inflammatory effect on the mucous membranes damaged by inflammatory processes, thereby contributing to their regeneration.

Contained in calendula carotenoids, flavonoids, resins, phytoncides, glycosides and other compounds have a high biological activity. The most powerful local antimicrobial effect is produced by essential oils, as well as organic acids of calendula officinalis, in particular, salicylic.

The complex of biologically active substances of this plant suppresses the production of specific protein-cytokines and selective inhibitors, which leads to the termination of synthesis in the tissues of hormone-like lipids - prostaglandins, which play a major role in inflammatory processes.

Thanks to the carotenoids contained in the calendula, Vagical promotes the acceleration of granulation and the healing of erosions of the mucous membranes of the female genitalia.

[8], [9], [10], [11], [12], [13], [14],

Pharmacokinetics

Vaginal suppository Vagical after the introduction begin to dissolve, releasing the active substance of the drug, which after a short time begins to have a therapeutic effect on the mucosa of the vagina and vulva.

Included in the preparation as a base, auxiliary substances - macrogols - are water-soluble thermoplastic polymers (polyethylene glycols). In the food industry, under the "food additive E 1521" index, they are used as a thickener; in the pharmaceutical industry - in the production of laxatives, suppositories and ointments. According to the manufacturer Vagikal, the marigolds do not interact with the active substance, are not metabolized, do not change the pH level of the vagina and do not penetrate through its biological membranes. It is also indicated that "macrogols act irrespective of the composition of the vaginal microbiocenosis," and the nature of this action is not specified.

It is known that macrogols have the ability to hide membrane sites (epitopes) of antigen-recognizing receptors of B-lymphocytes and T-lymphocytes from the corresponding antigen-binding centers (paratopes) of human antibodies.

[15], [16], [17], [18], [19], [20], [21]

Dosing and administration

Vagical suppositories are used for intravaginal administration. To evenly distribute the active substance on the walls of the vagina, before administration, the suppository should be moistened with boiled water at room temperature.

Vagical is used only for adults - 1 suppository 2-3 times a day. Duration of treatment the doctor determines individually, the average course of treatment is from 7 to 10 days.

For the period of menstruation, the use of the drug is suspended and continues after the completion of critical days.

[27], [28]

Use Vagikal during pregnancy

Information about the use of Vagical during pregnancy by the manufacturer of the drug is not provided.

Contraindications

Vagical is contraindicated to use with increased individual sensitivity to the drug.

[22], [23], [24]

Side effects Vagikal

The drug is considered safe, with individual drug intolerance possible side effects in the form of allergic reactions.

[25], [26]

Overdose

Information on the cases of his overdose during treatment is absent.

[29], [30], [31], [32], [33]

Interactions with other drugs

Information on the interaction of Vagical with other drugs during treatment is absent.

[34], [35], [36]

Storage conditions

Storage conditions Vagical - at room temperature, do not allow freezing in the refrigerator or freezer.

[37], [38], [39], [40]

Shelf life

Shelf life is indicated on the product package.

[41], [42]