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Vagicline
Last reviewed: 03.07.2025
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Vagiclin is an antimicrobial and bactericidal agent that is actively used in gynecological practice.
Indications Vagicline
The drug is used to treat bacterial vaginosis and other infectious gynecological diseases, the causative agent of which is sensitive to Vagiclin. The drug is also used for antimicrobial treatment of the vagina before the onset of labor.
Release form
The drug Vagiclin is produced in the form of soft vaginal capsules, each of which contains the active substances clindamycin and clotrimazole 100 mg each.
The accompanying substances are silicone oil, white wax, gelatin, titanium dioxide, methyl parahydroxybenzoate, propyl parahydroxybenzoate and sorbitol.
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Pharmacodynamics
The active ingredients of Vagiclin are clindamycin (a lincosamide antibiotic) and clotrimazole (an imidazole derivative, an antifungal drug). The combination of these agents can prevent the growth of yeast-like fungi that can develop under the influence of clindamycin. This semi-synthetic antibiotic inhibits the production of bacterial proteins by affecting their ribosomes and influencing the processes of protein chain initiation. Although this antimicrobial agent is inactive in laboratory tests, in a living organism it immediately undergoes an ion exchange reaction, which produces a substance capable of destroying bacteria.
The antibiotic is active against a large number of gram-positive and gram-negative anaerobic infections, as well as gram-positive aerobic bacteria. It is effective against microorganisms that can cause bacterial vaginosis.
The second active substance, clotrimazole, is a synthetic antifungal and antitrichomonal drug, an imidazole derivative. The action of this agent is aimed at inhibiting the production of ergosterol, which is necessary for the creation of the fungal cell membrane. Due to this, the permeability of the membrane is disrupted, which provokes further dissolution of the cell.
Clotrimazole also increases the permeability of phospholipid liposomal capsules, reduces the total number of ribosomes. Thanks to the drug, hydrogen peroxide accumulates in the fungal cell, which contributes to its destruction.
Clotrimazole has a detrimental effect on yeast-like fungi, dermatophytes, streptococcal and staphylococcal infections, and trichomonas.
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Pharmacokinetics
When the drug is used intravaginally for three days, approximately 30% is systemically absorbed.
The systemic effect of the drug when administered intravaginally is significantly weaker than when administered orally or by injection.
Active substances are metabolized in the liver and excreted from the body in the feces.
Dosing and administration
The drug Vagiklin is used intravaginally. The capsule is inserted deep into the vagina, it is more comfortable to do this in a lying position with legs bent at the knees. Use one intravaginal capsule at night, for a week. If necessary, the doctor can prescribe an additional course of treatment.
The drug should not be used during menstruation.
For antibacterial treatment of the vagina before the onset of labor, the product is used once or twice.
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Use Vagicline during pregnancy
The drug is used during pregnancy in the second and third trimesters, but only in cases where the expected effect from use will be proportionately greater than the potential danger to the unborn child. During pregnancy, as well as during lactation, the drug is used only with the doctor's prescription and under his strict control and supervision.
Contraindications
Absolute contraindications to the use of the drug Vagiclin are considered to be hypersensitivity of the body to the components of the drug, the first trimester of pregnancy.
When taking the drug, you should not have sex (even with a condom), use tampons or douche.
This drug is not used during menstruation.
The use of the drug is not recommended (but may be reviewed by the attending physician) in the presence of sexually transmitted diseases, irregular menstrual cycles, vaginal bleeding of unknown etiology, ulcerative lesions of the external genitalia, urination disorders, febrile conditions, dyspeptic disorders, in childhood.
Side effects Vagicline
Intravaginal capsules Vagiclin may cause the following side effects:
- intravaginal pain;
- complication of fungal infection;
- menstrual cycle disorders;
- the appearance of vaginal discharge;
- urinary disorders;
- inflammatory process in the kidneys;
- pain throughout the body;
- lowering of pressure;
- digestive disorders;
- itching of the skin;
- burning in the vagina;
- headaches.
If these symptoms do not go away within a week, you should consult a doctor.
The drug does not affect reaction speed, so its use does not affect the ability to drive a vehicle.
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Overdose
If you follow all the rules and recommendations for using the drug Vagiclin, there is no danger of overdose. Accidental use of capsules inside also does not cause any toxic damage to the body.
There have been no reported cases of overdose.
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Interactions with other drugs
Here are some data on the interaction of Vagiclin when used with other drugs:
- Clindamycin may enhance the medicinal effect of drugs that block muscle innervation;
- the use of the drug together with nystatin reduces the effectiveness of clotrimazole;
- Propyl ester of oxybenzoic acid enhances the antimicrobial effect of the drug.
Storage conditions
Capsules can be stored in cool, dry conditions, possibly in the refrigerator, out of reach of children.
Special instructions
Shelf life
The shelf life of the drug is up to 2 years.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Vagicline" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.