Cefutil

Cefutil is an antibacterial drug for systemic use. It is included in the subgroup of 2nd generation cephalosporins. It has an antibacterial effect.

Axetil cefuroxime is an oral form of cefuroxime (bactericidal cephalosporin); the component is resistant to most β-lactamases and shows an effect against a wide range of gram-negative and β-positive bacteria.[1]

The bactericidal effect of cefuroxime is associated with the suppression of the binding processes of the membrane of microbial cells. [2]

Indications Cefutil

It is used for such violations:

• diseases of the pharynx, ears and paranasal sinuses;
• pleurisy , tracheitis and bronchitis;
• urethritis with pyelonephritis and cystitis;
• colpitis and cervicitis ;
• impetigo and furunculosis, as well as streptoderma;
• active form of arthritis and bursitis;
• pathologies affecting the gastrointestinal tract.

Release form

The release of the drug is made in tablets with a volume of 0.125, 0.25 and 0.5 g.

Pharmacodynamics

The drug demonstrates high activity against staphylococci (this includes strains resistant to penicillin), Proteus, moraxella, streptococci, Clostridia with gonococci, Escherichia, Haemophilus influenzae, Salmonella and Haemophilus parainfluenzae.

Campylobacter, clostridia dificile, Acinetobacter calcoaceticus and listeria monocytogenes are resistant.

Pharmacokinetics

After oral administration, it is absorbed inside the intestine, hydrolyzed in the area of its mucous membrane, and then enters the bloodstream. Plasma Cmax values are noted after 2-3 hours.

The medication passes well into all tissues, overcomes the BBB and the placenta. The half-life is 60-90 minutes. Protein synthesis - within 35-55%.

It is excreted through the kidneys within 24 hours. In the case of dialysis, cefuroxime values decrease.

Dosing and administration

The tablets are taken orally, after a meal (to improve absorption).

For the treatment of most infections that occur without complications (pyelonephritis and bronchitis), the medication is used at a dosage of 0.25 g 2 times a day. If the infection is severe, the daily portion is increased to 1 g, dividing it into 2 uses. With cystitis, the use of 125 mg 2 times a day is required. The duration of the cycle is within 5-7 days.

In the case of pneumonia, first (for 3 days) intramuscular injections are given, and then the patient is transferred to the oral form of drugs - 0.5 g 2 times a day.

For therapy for uncomplicated gonorrhea, 1 g of the drug is taken once a day.

With tick-borne borreliosis, a 2-fold intake of 0.5 g of the substance per day is required.

Persons with impaired renal function and the elderly can use the medicine in dosages of no more than 1 g per day.

Most infections are treated with 0.125 g of medication 2 times a day. If the infection is severe, take 2 times 0.25 g. Adults over 12 years of age are prescribed adult dosages.

• Application for children

The tablets can be administered to children over 3 years of age.

Use Cefutil during pregnancy

Cefutil is used with caution in the 1st trimester.

Contraindications

It is contraindicated to use in case of severe intolerance to the drug and any cephalosporins.

Side effects Cefutil

The main side symptoms:

• erythema multiforme, pruritus, anaphylaxis, serum sickness and urticaria;
• vomiting, abdominal pain, diarrhea and nausea;
• candidiasis;
• dizziness and headaches;
• an increase in transaminases;
• hepatitis or jaundice;
• leuko-, neutro- or thrombocytopenia and eosinophilia.

Overdose

In case of poisoning, convulsions and psychomotor agitation develop.

It is necessary to perform gastric lavage, take sorbents and carry out symptomatic measures. The active element of the drug can be excreted by hemodialysis.

Interactions with other drugs

Medicines that lower the pH level decrease the bioavailability values of cefuroxime.

The use of Cefutil with probenecid and phenylbutazone increases the plasma values of its active component.

The medication weakens the effect of oral contraception.

Use in combination with diuretics (ethacrynic acid or furosemide), colistin, amphotericin, aminoglycosides and polymyxin increases the likelihood of developing kidney failure.

Combination with aminoglycosides also leads to renal dysfunction.

It is forbidden to use the drug together with chloramphenicol, macrolides and tetracyclines.

The combination with erythromycin can lead to a decrease in antibacterial activity.

It is forbidden to use with NSAIDs - due to the high likelihood of bleeding.

Storage conditions

Cefutil is required to be stored at temperatures no more than 25 ° C.

Shelf life

Cefutil can be used for a 3-year (tablet volume 0.125 and 0.25 g) and 4-year (tablet volume 0.5 g) term from the date of manufacture of the therapeutic product.

Analogs

The analogs of the drug are the substances Taxocef, Cefuroxime, Ketocef with Kimacef, Axetin and Zinacef.

Reviews

Cefutil is considered a good medicine - low toxicity, rare development of side signs, ease of use and a reasonable price are distinguished from its advantages. High medicinal efficacy and ease of use provide the drug with wide popularity among patients. But at the same time, he receives rather conflicting reviews. Probably, this can be associated with the severe nature of the pathology and the resistance of bacteria to this antibiotic.