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Ubretid
Ubretid belongs to the group of anticholinesterase agents, the active substance of the drug is distigmine bromide.
When taking ubretide, it is not recommended to control transport or other mechanisms, since the drug is able to influence the reaction rate.
Ubretyd is used no more than once a day, with a prolonged course of treatment, take a break (a day or two) to prevent cumulation of distigmine bromide.
Indications Ubretid
Indications for the use of ubretides are as follows:
- Postoperative weakening of intestinal muscle tone.
- Excessive accumulation of gases in the intestine.
- Paralytic intestinal obstruction (against the background of a decrease in the tone of myocyte intestines).
- Atonic constipation.
- Megacolon.
- Atony of the urinary tract.
- Violation of the sphincter of the bladder, as well as its hypotension.
- Rapid fatigue of cross striated muscles ( myasthenia gravis ).
- Peripheral muscle paralysis.
Pharmacodynamics
Pharmacodynamics ubretid: the effect of the drug comes in an hour and a half after use. Ubretid increases the peristalsis of the organs of the gastrointestinal tract, the tone of the organs of the urinary system, skeletal muscle tissue, causes relaxation of smooth muscles in the walls of the blood vessels, slows the heart rate, moderately increases the functioning of the glands of external secretion.
Contraindications
Contraindications to the use of ubretides are as follows:
- Increased acidity of gastric juice.
- Increased intestinal tone, biliary and urinary system.
- Intestinal obstruction (excluding paralytic).
- Stomach ulcer.
- Duodenal ulcer.
- Inflammatory processes in the large intestine.
- Inflammatory processes in the small intestine.
- Convulsive illness.
- Idiopathic cider of parkinsonism.
- Postoperative shock.
- Increased secretion of salivary glands.
- Decreased heart rate.
- Low blood pressure (hypotension).
- Chronic heart failure.
- Myocardial infarction.
- Increased thyroid hormone levels.
- Inflammation of the iris of the eyeball.
- Tonic muscle spasms (Thomsen's disease).
- Convulsions caused by impaired calcium metabolism.
- Bronchial asthma.
- Pregnancy.
- Breastfeeding period.
- Occlusion disorders of peripheral circulation.
Side effects Ubretid
Side effects of ubretid can cause nausea, vomiting, diarrhea, intestinal colic. Bronchospasm, increased secretion of salivary glands, increased motor activity of the stomach and intestines, a decrease in the heart rate, increased separation of sweat, muscle spasms, pupillary constriction, tremor, impaired swallowing, muscle twitching, myasthenia gravis, and dysmenorrhea are also side effects of the ubretside drug.
Dosing and administration
Dosage and administration: ubretid is taken at five milligrams daily, then the dose is increased to ten milligrams per day or, conversely, reduced to five milligrams once every two to three days, depending on the indications.
Tablets take on an empty stomach for half an hour before eating.
Intramuscular injection of 0.5 mg, each subsequent administration is not earlier than a day. With prolonged therapy should be for two or three days to stop taking the drug after its use for five to seven days.
For elderly patients, as well as people suffering from vagotonia, doses are calculated individually and can be reduced. With myasthenia, the dosage of the drug can be increased.
Overdose
An overdose of ubretid can cause symptoms such as nausea, vomiting, diarrhea, spasm of the gastrointestinal tract, increased intestinal peristalsis, increased secretion of salivary glands, bronchospasm, reduced heart rate, narrowing of the pupil, myasthenia gravis, muscle twitching.
To neutralize the symptoms of an overdose subcutaneously or intravenously, 0, 5 - 1 mg of atropine is administered. With the development of the cholinergic crisis, it is necessary to find a patient in the hospital for care.
Medical expert editor
Portnov Alexey Alexandrovich
Education: Kiev National Medical University. A.A. Bogomolets, Specialty - "General Medicine"
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Attention!
To simplify the perception of information, this instruction for use of the drug "Ubretid" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.