Tavegil

Tavegil is a synthetic anti-allergic (antihistamine) drug of a group of ethanolamine blockers of histamine receptors. Other trade names for this drug are Alagil, Anghistan Clemastin, Lecazole, Meklastine, Mekloprodin fumarate, Rekonin, Rivtagil, Tavist, Fumartin.

Indications Tavegil

Tavegil is prescribed for allergies, which are manifested as:

• vasomotor rhinitis (nasal congestion and runny nose),
• skin rashes and skin itching,
• and also with dermatoses accompanied by itching,
• reactions to insect vinegars and allergy to medicines.

Tavegil (injections) is used for serum sickness, in case of angioedema (Quincke's edema) and anaphylactic shock.

Release form

Tavegil is available in the form of tablets (0,001 grams), syrup (in 60 ml or 100 ml bottles, a measuring spoon is attached) and 0.1% solution for injections (in 2 ml ampoules).

[1]

Pharmacodynamics

The therapeutic effect of Tavegil is based on its active substance - 1-methyl-2- [2- (α-methyl-p-chlorobenzhydryloxy) -ethyl] -pyrrolidine in the form of fumarate, which affects the release of the endogenous neurotransmitter of allergic reactions of the immediate type, histamine.

This is due to blocking the stimulation of cells located on the outer surface of the cytoplasmic membrane of peripheral H1 receptors of histamine. As a result, the synthesis of histamine does not increase, capillary permeability decreases, and as a consequence, allergic reactions of the body are suppressed in the form of skin hyperemia and itching, irritation and edema of the mucous membranes, bronchial spasms,

[2], [3]

Pharmacokinetics

Absorption of Tavegil in the digestive tract with ingestion is almost 100%, and on average after three hours in blood plasma the maximum concentration of its active substance is reached. 90-95%, the drug binds to blood plasma proteins; bioavailability is 39%.

After 5-6 hours after taking the maximum protivogistaminnoe effect of the drug, which can last from 10 hours to 24 hours.

From the blood plasma Tavegil comes out in two stages: a part - about 3.5-4 hours later, the rest - after 1.5-2 days. Biological transformation of the drug occurs in the liver, more than half of the products of its decay are excreted from the body by the kidneys - with urine, in which there may be small amounts of unchanged active substance.

[4], [5]

Dosing and administration

Tavegil in the form of tablets is taken orally before meals. The standard therapeutic dose for adults and children over 12 years is 1 tablet (0.001 g) twice a day in the morning and in the evening). Dosage for children aged 6-12 years is 0.0005 g (half-tablet) twice per day. The maximum allowed daily dose is 0.006 mg.

Tavegil in the form of syrup is taken orally: adults and children after 12 years - 10 ml twice a day; children 1-3 years - 2.5-5 ml per day; 4-6 years - 5 ml; 7-12 years - 5-10 ml.

The solution for injections is injected into the muscle or into a vein - 2 mg 2 times a day. For children, the drug is administered only intramuscularly (25 μg per kilogram of body weight).

[10], [11]

Use Tavegil during pregnancy

The use of Tavegil during pregnancy, as well as during breastfeeding is contraindicated.

Contraindications

Among the contraindications to the use of Tavegil are:

• increased sensitivity to antihistamines;
• children up to 12 months;
• bronchial asthma;
• a stomach ulcer (especially with narrowing of the pylorus of the stomach);
• pathology of the thyroid gland (hyperthyroidism, thyroiditis, etc.);
• diseases of the prostate (with problems of urination);
• increased blood pressure (arterial hypertension);
• glaucoma (closed-angle).

[6], [7], [8]

Side effects Tavegil

Possible side effects of this medication may be headache, dizziness, fatigue, dry mouth, decreased appetite, nausea, constipation or diarrhea, epigastric pain, frequent or difficult urination, shortness of breath, difficulty in separating sputum from coughing, anaphylactic shock .

The use of Tavegil in the treatment of children can give such side effects as agitation, increased nervousness, sleep disorders, numbness of the limbs, convulsions.

[9],

Overdose

With an overdose of Tavegil, dry mouth is observed; dilated pupils; hyperemia of the skin of the face, neck and upper chest; digestive disorders; the state of oppression (in adults) or excitement (in children).

In such cases, it is necessary to rinse the stomach and take activated charcoal.

Interactions with other drugs

Tavegil enhances the effect of soothing and hypnotics, drugs for general anesthesia, neuroleptics and alcohol-containing medicines (tinctures).

Simultaneous reception of Tavegil with antiparkinsonian drugs, selectively acting on monoamine oxidase (Fenelzin, Azafen, Bethol, Iproniazid, Nialamid, etc.) also potentiates their effect.

Similarly, Tavegil's interaction with acetylcholine antagonists (m-holinoblokatorov), used in the treatment of bronchial asthma, chronic obstructive pulmonary disease, etc.

[12], [13], [14]

Storage conditions

The drug should be listed in list B, it must be stored in a dry, protected from light place, at a temperature of + 18-25 ° C.

Shelf life

The shelf life of Tavegil in tablets is 5 years, solution for injections and syrup - 3 years.

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