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Ubistezin forte
Last reviewed: 03.07.2025
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Ubistesin forte belongs to a group of local anesthetics used in dental practice.
Active ingredients of the drug: articaine hydrochloride, epinephrine hydrochloride.
One milliliter of ubistesin forte solution contains forty milligrams of articaine hydrochloride and 0.012 mg of epinephrine hydrochloride.
Excipients of the drug: sodium sulfite, sodium chloride, water.
Indications Ubistezin forte
Indications for the use of Ubistesin Forte include the need for anesthesia during dental treatment, in particular, before the following procedures:
- Tooth extraction.
- Tooth filling.
- Grinding down the tooth before excision of pathologically altered tissue.
- Surgical intervention on gum or bone tissue.
- An operation for chronic sinusitis that requires opening the maxillary sinus by making an incision under the upper lip.
- Cystectomy, resection of the root apex of the tooth.
- Transosseous osteosynthesis.
Release form
Ubistesin forte is available in the form of a four percent injection solution in 1.7 ml cartridges.
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Pharmacodynamics
Pharmacodynamics of ubistesin forte: the drug is a combined agent for local anesthesia during dental treatment. Anesthesia occurs instantly and lasts from one to five hours. The active substance of the drug interacts with nerve receptors and prevents the conduction of impulses along the nerve fiber.
Pharmacokinetics
Pharmacokinetics of ubistesin forte: the active substance of the drug has a high diffusion capacity. The half-life is about twenty-five minutes. The maximum concentration is noted ten to fifteen minutes after administration. Binding to plasma proteins is ninety-five percent. Elimination of the drug is carried out by the kidneys. Epinephrine, which is part of the drug, is subject to rapid decay in the liver and other tissues.
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Dosing and administration
Method of administration and dosage of ubistesin forte: the rate of administration of the drug should be no more than 0.5 ml in fifteen seconds (one cartridge is administered within a minute).
To prevent the drug from getting inside the vessel, an aspiration test is performed.
To achieve an anesthetic effect, the required minimum of the drug should be used. The dosage of ubistesin forte during tooth extraction is 1.7 ml. During subsequent extirpation of other teeth, the dosage of the drug may be reduced.
During surgical interventions, the doses of the drug are adjusted depending on the duration of the procedure and the patient’s condition.
When administering the drug to children, the dosage is calculated individually based on body weight. The drug is not prescribed to children under four years of age.
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Use Ubistezin forte during pregnancy
There is no data on the safety of using the drug during pregnancy.
Contraindications
Contraindications to the use of Ubesticin Forte include hypersensitivity to the active ingredients of the drug (articaine hydrochloride and epinephrine), as well as to other components included in its composition.
Ubistesin Forte is contraindicated in patients suffering from Bouveret's disease (a sudden attack of palpitations with a frequency of one hundred fifty to three hundred beats per minute that suddenly appears and ends abruptly), coronary insufficiency, high blood pressure, hyperthyroidism, diabetes mellitus, and closed-angle glaucoma.
Side effects Ubistezin forte
Side effects of Ubistezin Forte may occur when administering too high doses of the drug, when it penetrates into a vessel, and also in case of individual intolerance to any of its components.
Side effects when administering Ubistesin Forte may be the following:
- Dizziness.
- Nausea.
- Vomiting reactions.
- Feeling sleepy.
- Lowering blood pressure levels.
- Increased heart rate.
- Decreased heart rate.
- Cramps.
- CNS disorders.
- Visual impairment.
- Fainting.
Sodium sulfite, which is part of the drug, can cause allergic reactions, particularly in people suffering from bronchial asthma, which can result in bowel problems, vomiting, asthma attacks, and shock.
Local side effects may include the development of swelling or inflammation at the injection site.
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Overdose
Overdose of ubistesin forte may lead to the following symptoms:
- A metallic taste in the mouth.
- Tinnitus.
- Dizziness.
- Nausea.
- Vomit.
- Feeling of anxiety.
- Dyspnea.
- Drowsiness.
- Tremor.
- Cramps.
- Respiratory paralysis.
- Tachycardia.
- Increase in pressure.
- Heart pain.
- Increased sweating.
If severe side effects develop due to an overdose of the drug Ubistesin Forte, emergency medical intervention is required.
Interactions with other drugs
Interactions of ubistesin forte with other drugs: with the simultaneous use of ubistesin forte with tricyclic antidepressant drugs and monoamine oxidase inhibitors, the development of a sympathomimetic effect and an increase in blood pressure is possible.
Vasoconstrictors enhance and prolong the local anesthetic effect of articaine.
Non-selective beta-adrenergic blocking drugs increase the risk of hypertensive crisis and a marked decrease in heart rate.
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Shelf life
The shelf life of Ubistezin Forte is twenty-four months.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Ubistezin forte" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.