Tavanic

The drug Tavanic belongs to the pharmacological group of fluoroquinolone antibacterial agents of the third generation. Other commercial names of the drug: Levofloxacin, Leflobact, Levaquin, Levolet, Glevo, Oftaquix, Tigeron, Flexid, Ecolevid, Eleflox.

Indications Tavanic

The high antimicrobial and antibacterial activity of the drug Tavanic determines its wide use in such inflammatory diseases of infectious etiology as:

• pneumonia, chronic bronchitis;
• acute otitis, sinusitis, sinusitis;
• abscesses (including abdominal and pelvic organs);
• furunculosis;
• infectious chronic prostatitis;
• acute cystitis, urethritis, pyelonephritis;
• chlamydia, mycoplasmosis;
• intestinal infections;
• tuberculosis.

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Release form

Tavanic is available in the form of an infusion solution (in 100 ml vials) and tablets (250 mg and 500 mg).

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Pharmacodynamics

The mechanism of antibacterial and antimicrobial therapeutic effect of the drug Tavanic is provided by the active substance of the drug - the fluoroquinolone derivative levofloxacin. This substance affects the cellular enzymes of bacteria and microbes. As a result, the synthesis of DNA and RNA is disrupted in the cells of pathogenic microorganisms, which causes morphological changes in the cytoplasm, membranes and cell walls and leads to their death.

Tavanic is active against beta-lactamase-producing gram-negative and gram-positive bacteria, as well as chlamydia, mycoplasma, Pseudomonas aeruginosa and Haemophilus influenzae, and enterobacteria.

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Pharmacokinetics

The active substance of the drug Tavanic is quickly absorbed from the digestive tract after oral administration, bioavailability is 99%.

From 24 to 38% of the drug binds to blood plasma proteins and penetrates into tissues and organs; the maximum concentration in the blood is achieved after 80 minutes.

Metabolism of a small part of Tavanic occurs by deacetylation and oxidation in the liver. More than 85% of the administered dose of the drug is excreted unchanged in the urine, about 4% is excreted in the large intestine. The elimination period of the drug is 48-72 hours.

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Dosing and administration

Tavanic solution is used for intravenous slow infusions in a hospital setting. The dosage is determined by the doctor based on the diagnosis and the patient's condition. The maximum duration of the infusion course is 14 days.

Tavanic tablets are taken orally, regardless of food intake, with water. The dose is determined individually, depending on the existing pathology. For example, when treating infectious inflammations of the urinary tract and ENT organs, one tablet (250 mg) is prescribed once or twice a day (for 10-14 days); for infectious chronic prostatitis - one tablet (500 mg) once a day (course of treatment - 28 days).

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Use Tavanic during pregnancy

The use of Tavanic during pregnancy and breastfeeding is contraindicated.

Contraindications

Contraindications to the use of Tavanic are: increased individual sensitivity to drugs containing fluorine; age under 18; epilepsy.

Also, this drug is not used in cases where treatment with glucocorticosteroids is prescribed due to the risk of decreased tendon strength and rupture.

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Side effects Tavanic

The use of Tavanic may be accompanied by side effects: headache or muscle pain, dizziness, weakness, sleep disturbance; nausea, vomiting, diarrhea, abdominal pain, dysbacteriosis; decreased blood pressure, a sharp drop in vascular tone, increased heart rate; increased appetite and sweating; tremor, movement disorders, sensory disturbances; muscle weakness and tendon rupture.

Possible side effects of Tavanic include acute renal failure, anemia, leukopenia, increased sensitivity of the body to UV radiation (photosensitivity), itching and redness of the skin, swelling of the mucous membranes, and suffocation.

There is also a risk of disruption of skin pigment metabolism and the development of severe myopathy with destruction of muscle tissue cells. The development of new infectious processes is not excluded.

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Overdose

Overdose of this drug leads to erosion of the mucous membranes, convulsions, vomiting and even loss of consciousness. Symptomatic therapy is used in case of signs of overdose.

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Interactions with other drugs

In case of using Tavanic simultaneously with antibiotics of the aminoglycoside group (Gentamicin, Kanamycin, etc.), beta-lactam antibiotics and the antiprotozoal drug metronidazole, a combined effect of all drugs is observed both in terms of therapeutic effect and in terms of the manifestation of their undesirable side effects.

When Tavanic is taken simultaneously with the bronchodilator drug Theophylline and non-steroidal anti-inflammatory drugs (NSAIDs), the likelihood of seizures increases.

Anti-heartburn medications containing magnesium, calcium and aluminum ions, as well as osmotic laxatives (Guttalax, Lactulose, Duphalac, Normase, etc.) reduce the activity of Tavanic, as they reduce the level of its absorption.

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Storage conditions

Storage conditions for Tavanic: at a temperature not exceeding +25°C, in a dry place protected from light.

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Shelf life

The shelf life of the drug in tablet form is 5 years; solution in vials - 3 years. Tavanic solution for infusions is not suitable for use after exposure to light for three days.

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