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Tavanik
The drug Tavanic belongs to the pharmacological group of third-generation fluoroquinolone antibiotics. Other commercial names of the drug: Levofloxacin, Leflobact, Levakvin, Levolety, Glevo, Oftakwix, Tigeron, Flexid, Ecolevid, Eleflox.
Indications Tavanik
High antimicrobial and antibacterial activity of the drug Tavanik causes its wide application in such inflammatory diseases of infectious etiology as:
- pneumonia, chronic bronchitis;
- acute otitis, sinusitis, sinusitis;
- abscesses (including abdominal and pelvic organs);
- furunculosis;
- infectious chronic prostatitis;
- acute cystitis, urethritis, pyelonephritis;
- chlamydia, mycoplasmosis;
- intestinal infections;
- tuberculosis.
Pharmacodynamics
The mechanism of antibacterial and antimicrobial therapeutic effects of the drug Tavanik is provided by the active substance of the drug - the fluoroquinolone derivative levofloxacin. This substance affects the cellular enzymes of bacteria and microbes. As a result, in the cells of pathogenic microorganisms, the synthesis of DNA and RNA is disrupted, which causes morphological changes in the cytoplasm, membranes and cell wall and leads to their death.
Tavanik is active against beta-lactamase-producing gram-negative and gram-positive bacteria, as well as chlamydia, mycoplasmas, Pseudomonas aeruginosa and hemophilic rods and enterobacteria.
Pharmacokinetics
The active substance of the drug Tavanik after intake is rapidly absorbed from the digestive canal, the bioavailability is 99%.
From 24 to 38% of the drug binds to blood plasma proteins, and penetrates tissues and organs; the maximum concentration in the blood is reached after 80 minutes.
Metabolism of an insignificant part of Tavanik occurs by deacetylation and oxidation in the liver. More than 85% of the accepted dose of the drug in unchanged form is excreted in the urine, about 4% is excreted by the large intestine. The withdrawal period is 48-72 hours.
Contraindications
Contraindications to the use of Tavanic are: increased individual sensitivity to preparations containing fluoride; age to 18 years; epilepsy.
Also, this drug does not apply to the appointment of treatment with glucocorticosteroids due to the threat of decreasing the strength of the tendons and their ruptures.
Side effects Tavanik
The use of Tavanik may be accompanied by side effects: headache or muscle pain, dizziness, weakness, sleep disturbance; nausea, vomiting, diarrhea, abdominal pain, dysbiosis; decrease in blood pressure, a sharp drop in vascular tone, increased heart rate; increased appetite and sweating; tremor, motor disorders, impaired sense organs; muscle weakness and tendon rupture.
Among the possible side effects of Tavanik are acute renal failure, anemia, leukopenia, increased sensitivity of the body to UV radiation (photosensitivity), itching and redness of the skin, swelling of mucous membranes, suffocation.
There is also a risk of disruption of skin pigment metabolism and the appearance of severe myopathy with the destruction of muscle cells. Development of new infectious processes is not ruled out.
Dosing and administration
Tavanic solution is used for intravenous slow infusions in a hospital. Dosage is determined by the doctor, based on the diagnosis and condition of the patient. The maximum duration of the course of infusions is 14 days.
Tablets Tavanik used inside - regardless of food intake, washed down with water. The dose is determined individually, depending on the existing pathology. For example, in the treatment of infectious inflammation of the urinary tract and ENT organs, one tablet (250 mg) is administered once or twice a day (for 10-14 days); with infectious chronic prostatitis - one tablet (500 mg) once a day (treatment course - 28 days).
Interactions with other drugs
In the case of using Tavanik simultaneously with the antibiotics of the aminoglycoside group (Gentamycin, Kanamycin, etc.), beta-lactam antibiotics and protivoprotoznym metronidazole drug observed the total effect of all drugs both on therapeutic effects and on the manifestation of their undesirable side effects.
With the simultaneous administration of Tavanik with a bronchodilator Teofillin and non-steroidal anti-inflammatory drugs (NSAIDs), the likelihood of seizures increases.
Means against heartburn, containing in its composition magnesium, calcium and aluminum ions, as well as laxative agents of osmotic action (Guttalax, Lactulose, Dufalac, Normaze, etc.) reduce Tavanic activity, as it reduces its absorption level.
Medical expert editor
Portnov Alexey Alexandrovich
Education: Kiev National Medical University. A.A. Bogomolets, Specialty - "General Medicine"
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Attention!
To simplify the perception of information, this instruction for use of the drug "Tavanik" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.