Penester

Penester contains the active element finasteride, which is an artificial azasteroid compound. This component specifically inhibits the activity of 1st generation 5-α reductase.

5-α reductase itself is an intracellular enzyme that helps convert testosterone into a slightly different form - 5-dihydrotestosterone. The increased volumes of the latter inside the blood cause an enlargement of the prostate, as a result of which its hyperplasia begins to develop. [1]

Indications Penester

It is used for pharmaceutical treatment in the case of having a benign hyperplasia of the prostate . It is used to reduce the likelihood of acute urinary retention and the need for surgery. Also, the medicine helps to shrink the prostate in size, increase the volume of urine excreted and facilitate the process of urination.

There is information about the successful use of drugs in the treatment of alopecia , but after discontinuation of Penester, this disorder develops again.

Release form

The release of the drug product is realized in tablets with a volume of 5 mg, 10 pieces each inside a cell pack. There are 3 such packs inside the box.

Pharmacodynamics

The use of the drug causes a significant decrease in the level of dihydrotestosterone within the cells of the prostate as well as within the blood. As a result, there is a slowdown in the progression of hyperplasia with a further decrease in the size of the prostate. All this allows you to normalize the process of urination.

The use of the medication does not lead to a change in the blood values of prolactin, thyroxine with cortisol and TSH. It also does not affect lipid metabolism. [2]

Pharmacokinetics

After taking the medication inside, there is a slow adsorption of finasteride from the gastrointestinal tract. The values of plasma Cmax Penester reaches after 120 minutes. The index of intraplasmic synthesis with protein is 93%.

The processes of drug metabolism are realized inside the liver, and excretion occurs with urine and feces. The half-life is 6 hours, but in older people (over 70 years old) it can be extended and reach up to 8 hours. [3]

Dosing and administration

The medicine is taken orally, swallowing the tablet without chewing, drinking plain water. During the day, 5 mg of the substance is usually taken 1 time, without reference to the use of food.

The treatment process should be lengthy. The development of the clinical effect is often noted only after 3-6 months of continuous drug intake.

Clinical symptoms of prostatic hyperplasia disappear completely, mainly after 1 year of treatment, although sometimes a longer course is required.

• Application for children

It is forbidden to prescribe Penester in pediatrics.

Use Penester during pregnancy

Women of reproductive age, as well as pregnant women, should not come into contact with finasteride (also with its crushed tablets), because it can cause disorders in the development of the genitals in a male fetus. Given that small amounts of finasteride are excreted with sperm, women in this group should use contraceptives when having sex with men who are taking the medication.

Contraindications

Among the contraindications:

• strong personal sensitivity regarding medicinal elements;
• malignant tumors in the prostate area;
• obstruction affecting the urethra;
• use in women.

Caution is required if the medication is taken by persons with hepatic disorders.

Before starting the use of drugs, it is necessary to exclude the presence in the patient of such pathologies as prostatitis of an infectious nature, prostate carcinoma, hypotension affecting the bladder, as well as other diseases with signs similar to those observed with benign prostatic hyperplasia.

Side effects Penester

With the introduction of the drug, disorders such as a decrease in ejaculate volume, weakening of libido and impotence can be noted.

Men may experience pain in the mammary glands and gynecomastia, but these symptoms disappear after drug withdrawal.

Epidermal allergies and testicular pain may occur.

Laboratory tests have shown a decrease in prostate-specific antigen values.

Storage conditions

The penester should be stored in a dark and dry place at temperatures not exceeding 25 ° C.

Shelf life

Penester is allowed to be used within 24 months from the date of manufacture of the therapeutic substance.

Analogs

The analogs of the drug are the substances Adenoprostal, Trianol, Proscar with Gestonorona caproat, Prostamol Uno and Peponen with Permikson and Prazosin, and in addition to this Adenorm, Prostatilen, Prostamed with Raveron and Longidaza. Also on the list are Serpents, Prostaplant with Derinat, as well as Tykveol, Avodart and Cernilton.