Clotrimazole ointment (Candide ointment, Kanesten and other synonyms) contains an imidazole derivative clotrimazole that inactivates mitochondrial peroxidase enzymes in candidate cells, reduces the biosynthesis of sterols necessary for the formation of the glycoproteinadegine membrane of the fungal cells, which multiplies not by spores but by budding. As a result of a lack of sterols, the plasma membranes of the fungal cells lose their impermeability, and together in it the ability to multiply and exist.
The drug Lomexin in the form of a vaginal cream acts in the same way, but already due to another imidazole derivative - fenticonazole, in zalain ointment an active antifungal agent is the antimycotic sertaconazole, and the pharmacodynamics of the ointment from the thrush Miconazole is based on the action of miconazole nitrate.
Thanks to nystatin (antibiotic-polyene mycosaminilistinistanolide), Nystatin ointment also acts on the cell membrane of the fungi, and, integrating into it at the molecular level, irreversibly increases the intracellular osmotic concentration of electrolytes, lowers the pH level and disrupts the oxygen consumption by the cells of the fungus. All this in aggregate provokes coagulation of cytoplasmic proteins, leading to lysis of C. Albicans cells.
An antifungal action similar to nystatin is provided by ointment from thrush Levorin (with a heptaenic aromatic antibiotic levorin).
Ointment Pimafucin contains polyene natamycin, the pharmacodynamics of which is similar to clotrimazole. Ointment Pimafukort, in addition to natamycin, has in its active against many bacteria antibiotic neomycin and hydrocortisone, which removes inflammation and itching of the skin with thrush.
The Tridentum ointment includes corticosteroid betamethasone, antibiotic gentamicin and clotrimazole. The action of clotrimazole has been described above; gentamycin prevents the attachment of a bacterial infection, and a corticosteroid helps to relieve inflammation and itching.
And although all of these remedies reduce the appearance of symptoms of candidiasis, due to corticosteroids in the composition of Pimafukort and Triderm, both of the itching from itching with thrush is most effective.
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