Magne-B6 premium

Modern man-made society has made human life emotionally uncomfortable. One of the reasons predisposing a person to stress, is the lack in his body of an element such as magnesium. This chemical element is actively involved in a variety of physiological and biochemical processes taking place in the body, so its shortage significantly affects the overall health of a person. In such a situation Magne-v6 premium will come to the rescue - a highly effective medical preparation that can solve the problem of magnesium deficiency in the patient's body. But it is worth noting that you should not throw off food. A balanced diet rich in magnesium-containing products is also capable of at least partially removing the problem of the lack of this element.

Indications Magne-B6 premium

Pharmacological characteristics of magnesium citrate and pyridoxine "dictate" the indications for Magne-c6 premium use.

• Replenishment of the lack of magnesium in the human body, both isolated and in the compound.
• Primary, or congenital, anomaly of metabolism (chronic hypomagnesemia).
• Magne-c6 premium is allowed for admission and adult patients and babies of even a small age (their weight should be at least 10 kg, which roughly corresponds to one-year age).
• The lack of magnesium in the body can be caused by:
  • Severe form of anemia associated with malnutrition.
  • Smoking, adherence to alcoholic beverages, drug addiction.
  • Diarrhea of chronic course.
  • Abuse of diuretics.
  • Hypoparathyroidism - endocrinopathy associated with inadequate synthesis of the parathyroid hormone - parathyroid hormone.
  • Fistulas in the gastrointestinal tract.
  • Heavy form of polyuria.
  • Chronic pyelonephritis.
  • Primary hyperaldosteronism is the state of the body, due to the improper work of the endocrine system of which the adrenal cortex begins to produce an excessive amount of the aldosterone enzyme.

Symptoms that indicate a deficiency of this element:

• There is a sense of creepy, running microcurrents in the muscles of the body.
• Convulsive symptoms.
• Increased nervousness, a sense of anxiety.
• Fast fatiguability.
• Irritability.
• Psychoemotional lability.
• Easy insomnia.
• Minor spasms in the gastrointestinal system.
• Attacks of minor tachycardia ( rapid heartbeat ).
• Paresthesia is a sensitivity disorder.

[1], [2], [3]

Release form

For adults and toddlers who are more than six years old, it is recommended to take a form of release - tablets containing anhydrous magnesium citrate in the amount of 618.43 mg (this volume corresponds to 100 mg of mono magnesium) and 10 mg of pyridoxine hydrochloride. The unit of the drug is white and oval in shape. To the additional chemical compounds include macrogol 6000, anhydrous lactose, lactate and magnesium stearate. The tablet is coated with a coating consisting of titanium dioxide, hypromellose, macrogol 6000 and talc.

On the shelves of modern pharmacies you can find Magne-6 for injections, the form of release - ampoules of 10 ml (№ 10).

Pharmacodynamics

Physiologically, ionized magnesium is referred to as cations - positively charged ions, which are located inside the cell. The chemical element magnesium effectively reduces the overexcitability of neurons, the increased reaction of which leads to emotional instability of the person. Magnesium reduces neuromuscular reactions that cause loss of sensation and spasm of muscles. He participates in most of the enzymatic processes that take place in the body.

Pharmacodynamics Magne-v6 premium affects and metabolic processes, here itself realizes pyridoxine (co-enzyme factor). The highest percentage of the magnesium-b6 premium compound is observed in bone tissues.

The concentration of magnesium in the blood determines the presence or absence of its deficiency:

• If the indicator of the quantitative content of the element shows a figure falling in the range from 12 mg to 17 mg per liter of blood serum (corresponding to 500-700 moles per liter or 1.0-1.4 mEq / liter) - in this case the doctor diagnoses a moderate level lack of magnesium in the plasma.
• The index of 17 mg per liter and above (which corresponds to 700 moles per liter or 1.4 mEq per liter) - indicates a sufficient amount of a chemical element for the normal operation of the human body.
• If the magnesium content indicator shows a figure less than 12 mg per liter of study medium (corresponding to 0.5 mmol per liter or 1.0 mEq / liter) - this indicates a severe form of magnesium deficiency.

[4], [5], [6], [7]

Pharmacokinetics

Up to half of the magnesium salts that enter the human body are absorbed by the mucosa of the gastrointestinal tract by simple mechanical absorption. The main role in this process is the ability of the salts to dissolve. Utilization and withdrawal of the drug is mainly carried out through the kidneys in conjunction with the urine, while the magnesium salts in the kidney canals undergo additional reabsorption - such is the pharmacokinetics Magne-c6 premium. The average index of magnesium in the urine is one third of the amount of this element that has been ingested with food.

The third part of the magnesium found in the compounds accumulates in the blood plasma, as well as in the striated and smooth muscles, but still the greater part "settles" in the intracellular space of the bone tissue.

[8], [9], [10]

Dosing and administration

If the drug is prescribed in the form of tablets, then it is recommended to swallow whole, without splitting, together with food. It is better to wash down with enough water. The method of administration and dose vary somewhat for different age groups of patients.

The starting dosage Magne-v6 premium for adult patients is three to four tablets, administered in two to three doses. In case of medical necessity, the quantitative component can be doubled, bringing the daily dose to six to eight tablets.

In the form of injections, the daily amount of the drug is used in three to four ampoules administered two to three times a day.

Children over the age of six (weighing more than 20 kg) the amount needed to administer the drug is calculated by the formula - from 10 to 30 mg Magne-c6 premium, taken per kilogram of weight of a small patient per day (approximately 0.4-1.2 mmol per kilogram of child's body weight per day). Usually this corresponds to two to four tablets, diluted two to three times. In the case of severe magnesium deficiency, the daily amount of the drug can be increased and brought to four to six tablets.

After the onset of the therapeutic effect (the level of magnesium in the blood has reached the norm), the drug should be stopped. Predominantly the duration of therapy covers one month. If the therapeutic effect does not occur after a month of taking the drug, it should still be canceled and a deeper examination performed to diagnose the underlying cause of the pathological shortage of magnesium in the body.

Children of the first year of life, weighing up to 10 kg, use oral Magne-v6 premium in the form of a solution. The starting daily dosage is from one to four ampoules administered in two to three doses throughout the day. Before giving the medicine to the baby, the ampoule must be opened and its contents diluted with half a glass of water at room temperature.

[18], [19], [20], [21]

Use Magne-B6 premium during pregnancy

Long-term monitoring and clinical studies have shown that the use of Magne-B6 premium during pregnancy is acceptable at any time. It should be noted that the drug should be administered and controlled by the treating doctor or obstetrician - the gynecologist who leads the pregnancy. At the same time, all the components of the drug both complexly and individually do not have any negative effect on breast milk, and it, in turn, and on the newborn. Therefore, Magne-b6 premium intake during lactation is acceptable.

Contraindications

As if the drug was unsafe, you still need to be more attentive to the purpose, schedule and dosage of any pharmacological drug. There are also contraindications to the use of Magne-c6 premium, although they are insignificant.

• Individual intolerance to one or more of the constituent components of the medication.
• If the creatinine clearance is below 30 ml per minute and a severe form of kidney dysfunction is observed.
• Lack of sugar - isomaltase and blood of the patient.
• Age of children under the age of six (for tablets).
• Hypersensitivity to fructose.
• Co-administration with levodopa (therapeutic therapy used for symptomatic relief in Parkinson's disease).
• Disturbance of absorption abilities (malabsorption) of glucose or galactose.

[11], [12], [13]

Side effects Magne-B6 premium

The use of the drug in question in the protocol of treatment can provoke side effects of Magne-c6 premium, which give such symptoms:

• The appearance of a loose stool (diarrhea) with concomitant manifestations.
• Pain in the abdomen (abdominal pain).
• Allergic manifestations, affecting the skin.
• Another manifestation of allergy.
• Spasmodic bronchi.

[14], [15], [16], [17]

Overdose

Advantageously, when Magne-b6 is injected into the patient in an elevated manner, a toxic reaction is not observed in the case of normal kidney function. However, if the patient suffers from kidney failure, an overdose of magnesium can give side symptoms. In this case, the body can react to magnesium poisoning:

• A sharp drop in blood pressure.
• Attacks of nausea, the increased intensity of which can lead to vomitive manifestations.
• The suppression of the nerve endings of the central nervous system.
• Reflex disorders.
• Failures in the work of the heart muscle.
• The inhibition of respiratory processes, up to a coma, characterized by paralysis of the respiratory system and cardiac arrest.
• Decreased general vitality (anuric syndrome).

When this symptom appears, urgent rehydration of the patient's body is necessary (causing a vomiting reflex, washing the stomach), forced diuresis with the help of strong medications. In the case of severe renal failure, hemodialysis or peritoneal dialysis can not be avoided.

Interactions with other drugs

Even the most harmless, but useful vitamin, it is necessary to take very carefully in the complex therapy, so as not to stop the action of other drugs or cause another undesirable reaction. Therefore, the interaction of Magne-v6 premium with other drugs must be known.

Do not use the drug in question with  levodopa, since magnesium-b6 premium in this case significantly decreases the activity of levodopa, and even completely blocks it. Exit from the created position - an additional connection of peripheral dopa-decarboxylase.

It is not necessary to administer calcium salts or phosphate compounds together with the preparation in question . They are able to quench the possibility of magnesium absorbed by the mucosa of the small intestine.

With great care it is necessary to treat the necessity of tandem use of Magne-c6 premium with tetracyclines, since magnesium is able to reduce the gastric absorption of the latter. In order to prevent this, it is necessary to administer the medication orally to the patient at intervals of two hours.

[22], [23], [24],

Storage conditions

The main storage conditions of magne-c6 premium are similar to the basic requirements for any pharmacological preparation:

• The temperature of the room should not exceed 30 ^° C.   
• The storage location must not be exposed to direct sunlight.
• The Magne-v6 premium drug should not be available to young children.

Shelf life

Two years is the shelf life of the drug, which is always marked on the packing box, and duplicated on the blasters of tablets or ampoules of solutions. Categorically it is not recommended to use the drug after this expiration date.