Lesfal

L'isfal has proven itself in diseases of the liver, bile ducts, psoriasis, when cleaning the liver from traces of toxic intoxication, from radiation effects, and also the drug well reduces severe manifestations of toxicosis during pregnancy. L'isfal has practically no contraindications (except for individual intolerance), besides it is safe during pregnancy and lactation.  

The active substance of the drug L'sfal is soy lecithin, a natural substance that has beneficial properties for the human body. Soy lecithin contains substances that dissolve and burn fat, i.e. Protect the liver, gallbladder, blood vessels from cholesterol. It is due to its similarity to the fat tissue, lecithin contributes to the natural splitting of fat (moreover, only excessive in the body fat), takes an active part in the oxidation process.

[1]

Indications Lesfal

L'isfal is used for:

1. Diseases of the liver :

• liver degeneration;
• chronic hepatitis;
• cirrhosis of the liver.

2. Diseases of the biliary tract.
3. Toxic liver damage.
4. Toxicosis in pregnancy.
5. Radiation syndrome.
6. Psoriasis.

The results of numerous studies show that L'isfal improves metabolism in the liver, increases resistance to harmful effects, accelerates the process of cell regeneration and liver functions for various injuries.

In the human body, the liver performs many important functions: regulates carbohydrate metabolism, stores glycogen (energy reserve of the body), as well as vitamins and trace elements, detoxifies toxins and poisons that enter the body, etc.

The human liver has an amazing ability to recover. Even if only 25% of normal tissue is preserved, the liver is able to restore its initial dimensions. But this process is very slow. Prolonged exposure to adverse factors (alcohol, viruses, hepatitis) leads to the fact that normal cells are replaced by a connective tissue, resulting in cirrhosis. The most common cause of cirrhosis of the liver is prolonged alcohol poisoning and hepatitis.

Various diseases lead to the fact that liver function weakens, the process of formation of bile is disrupted. Difficult bile flow into the intestine occurs often due to a variety of inflammatory processes of the gallbladder (cholangitis, cholecystitis, cholelithiasis, etc.). As a result of inflammation, the bile lingers in the bile, liver, begins to be absorbed into the blood. Insufficient amount of bile in the intestine disrupts the digestive process, especially digestion of fats is difficult.

[2],

Release form

Lesphal is available as a solution for injections, in ampoules of 5 ml. Depending on the packaging, the package contains 5 or 10 ampoules.

Pharmacodynamics

Soy lecithin, contained in the preparation, in the composition has many polyunsaturated fatty acids. Lecithin molecules are embedded mainly in the structure of cell membranes, thereby facilitating the process of repairing damaged liver tissue. Lecithin, in medicine also known as phospholipid, affects the impaired lipid metabolism by regulating the metabolism of lipoproteins. As a result, cholesterol and neutral fats get a form suitable for transportation, in particular due to the increased ability of high-density fats to attach cholesterol, for the further oxidation process. The withdrawal of the drug occurs through the bile-excreting pathways, during this time the lithogenic index decreases and bile stabilizes.

[3], [4], [5], [6], [7]

Pharmacokinetics

Half-life from the body for the choline component of the drug is 66 hours (about 3 days), for saturated fatty acids - 32 hours. During the kinetic studies of the human body, it was found that about 5% of each of the deduced isotopes (14C and 3H) occurred by excretion with feces.

[8], [9], [10], [11], [12]

Dosing and administration

The drug is administered only intravenously and very slowly, if L-isphalus is administered intramuscularly, a local reaction may develop. The drug is prescribed for adults and children over 12 years for 5-10 ml per day (1 - 2 ampoules). In severe disease, you can increase the dose twice. At a time, you can enter no more than 10 ml of the drug. To dilute L'sfal use the patient's own blood 1: 1. The course of treatment is 10 days, further treatment continues with oral forms of the drug.

In psoriasis during the first two weeks, the oral form is prescribed, then a course of 10 intravenous injections is possible, while PUVA therapy (ultraviolet radiation) is also prescribed. After the course of intravenous injections comes to an end, the intake of oral forms of lecithin resumes.

If it happens that the dilution of the drug with the patient's blood is impossible, you can use solutions free of electrolytes (glucose, xylitol) in a ratio of 1: 1.

[18], [19], [20],

Use Lesfal during pregnancy

During pregnancy, L'isfal is used to treat severe cases of toxicosis. The drug has proven itself in toxicosis in pregnant women, it well relieves severe symptoms and alleviates the condition of a woman.

If there is a need for treatment during breastfeeding, L'isfal is used without fear, no adverse reactions or adverse effects on the body of the child through breast milk have been identified.

It contains alcohol and is used exclusively intravenously. Intramuscularly, local reactions are more difficult when the drug is administered.

Contraindications

L'isfal is contraindicated in case of individual intolerance of the drug components.

[13], [14], [15]

Side effects Lesfal

Rarely, with increased doses of the drug may occur violations in the digestive system (diarrhea). Sometimes there is a hypersensitivity reaction to the drug in the form of rash, itching, etc.

[16], [17]

Overdose

At present, there has been no information on L'sfal overdose, but as it was said, increased doses of the drug may cause diarrhea and lead to disruption of the work, the digestive tract. Sometimes there may be a local allergic reaction in the form of various rashes, itching, etc.

Interactions with other drugs

L'isfal is incompatible with electrolyte solutions, interaction with other drugs has not been studied. The drug should not be administered in the same syringe with other medicines.

[21], [22], [23], [24]

Storage conditions

L'isfal is stored in a place well protected from light and direct sunlight, at a temperature of 2 - 8 ⁰ C. It is necessary to ensure that the drug is out of reach of children.

[25], [26], [27], [28], [29],

Shelf life

Shelf life is 2 years from the date of manufacture, which is indicated on the package, subject to storage conditions. The drug can not be used after the expiration date

[30], [31]