Lasolvan for inhalation for cough: how to dilute, proportions, how many days to do

Inhalation of medicinal substances is a common and effective way to eliminate cough, phlegm in the lungs, sore throat and nasopharynx, etc. One of the drugs that can be administered by inhalation is Lazolvan for injections: it belongs to mucolytic drugs, which are included in the list of necessary drugs for the treatment of cough and colds.

Can I take Lazolvan for inhalation?

The instructions indicate that Lazolvan for inhalation is a solution intended for oral and inhalation use. Therefore, the product can be offered to a child by adding it to drinking liquids or in a nebulizer. Some specialists note that inhalation administration for colds and coughs is more acceptable, since the therapeutic effect occurs faster, and the medicinal component enters directly into the affected respiratory tract, bypassing the digestive tract.

However, sometimes it happens that it is not possible to carry out inhalation - for example, small children may simply be afraid of the inhaler device. In such a situation, do not despair: Lazolvan in the form of an inhalation solution is no less suitable for internal use. However, the dosages here are completely different, so you should first consult a doctor.

Indications Lasolvan for inhalation

Lazolvan for inhalation against cough is intended for the treatment of diseases of the upper respiratory system, which are accompanied by dry coughing fits, or wet cough with difficult expectoration.

General indications for prescribing inhalations are:

• diseases of the upper respiratory system (acute or chronic form) with complex formation and poor evacuation of sputum;
• attacks of dry cough without formation of sputum;
• acute or chronic type of bronchitis;
• pneumonia;
• presence of bronchiectasis;
• chronic obstructive pulmonary disease (COPD);
• insufficient separation of sputum in bronchial asthma.

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Release form

Lazolvan is presented in a wide range of medicinal forms, which allows you to choose the optimal medication for any category of patients.

Lazolvan spray is used for otolaryngological diseases: this drug has a vasoconstrictive property and softens the inflamed mucous membrane.

Lazolvan solution for oral administration and inhalation is one of the most versatile products, which is intended for oral or inhalation administration.

Lazolvan drops for inhalation are used at the rate of 25 drops = 1 ml of the drug. The properties of the drops are equivalent to the properties of the inhalation liquid for oral use.

Lazolvan syrup is intended for internal use only. Lazolvan syrup for inhalation is prohibited.

In addition, there is also a tablet version and lozenges of Lazolvan.

The composition of Lazolvan for inhalation is represented by the well-known mucolytic ambroxol, as well as secondary ingredients: purified water, citric acid monohydrate, disodium hydrogen phosphate dihydrate, sodium chloride, benzalkonium chloride.

One milliliter of Lazolvan for inhalation contains 7.5 mg of the active ingredient. The medicinal liquid is transparent, with a slightly brownish tint.

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Pharmacodynamics

There is evidence that the active ingredient of Lazolvan for inhalation is capable of increasing the secretory function of the respiratory glandular system. The drug potentiates the production of pulmonary mucus, directly affecting the cellular structures of the alveoli and bronchioles. Lazolvan also activates the ciliary system, which leads to accelerated mucus removal. Such properties were noted during clinical and pharmacological testing.

Stimulation of fluid production and mucus removal significantly alleviates the patient's condition. The cough becomes productive.

The local anesthetic effect of Lazolvan has also been proven experimentally and is explained by the blocking of sodium channels. Studies have demonstrated the ability of the drug to block neuronal sodium channels: the relationship was inverse and depended on concentrations.

Lazolvan also has an anti-inflammatory effect, reducing the release of cytokines and weakening the tissue connection between mononuclear and polymorphonuclear cell structures.

Clinical testing involving patients with pharyngitis has shown that pain and tissue hyperemia in the throat area are reduced after using Lazolvan for inhalation. The pain relief was particularly pronounced in relation to the upper respiratory system.

Lazolvan for inhalation may increase the concentration of antibiotics in bronchopulmonary secretions.

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Pharmacokinetics

Absorption of the basic ingredient of Lazolvan for inhalation is rapid and complete, depending on the dosage. Maximum amounts in the blood serum can be determined after 1-2.5 hours when taken orally (after 6.5 hours when using slow-release forms).

When administered orally, distribution is rapid and extensive, with the highest possible concentration of the drug in the lungs. The estimated distribution volume for oral administration is 552 l. In the blood serum, about 90% of the drug is bound to proteins.

The active ingredient is metabolized to a large extent in the liver. After 3 days, about 6% of the total dose is excreted in urine in preserved form, and about 26% in the form of a conjugate.

The half-life of Lazolvan is estimated at 10 hours. The total clearance rate averages 660 ml/minute. The renal clearance rate is 83% of the total rate.

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Dosing and administration

One milliliter of solution corresponds to 25 drops.

Adults and children aged six years and older are given 1-2 inhalations per day (daily dose 2-3 ml).

For children under six years of age, it is recommended to administer 1-2 inhalations per day (daily dose 2 ml).

Lazolvan can be used for inhalation in a nebulizer or other modern inhalation device, except for steam devices.

One procedure for a child under five years old can last about 3 minutes. For older children, the duration is increased to 5-10 minutes. The total duration of treatment is 10-14 days.

How to dilute Lazolvan for inhalation?

Before starting treatment, you must carefully read the instructions for use of Lazolvan for inhalation.

Unless otherwise prescribed by the doctor, the proportions of Lazolvan for inhalation should be as follows:

• Saline solution with Lazolvan for inhalation is diluted in a ratio of 1:1. This will ensure the best humidification of the air entering the respiratory organs. Sodium chloride and Lazolvan for inhalation are warmed up to human body temperature before use.
• Berodual and Lazolvan for inhalations are combined only by doctor's prescription. Before inhalations, adhere to the following rules:
  • for adults and adolescents over 12 years of age, use no more than 40 drops for one procedure (the daily number of procedures is no more than 4);
  • for children aged 6-12 years, 20 drops of Berodual are used for one inhalation (number of procedures – three per day);
  • for children under six years of age, 10 drops of Berodual per administration is sufficient (2-3 procedures per day are allowed).

3 ml of physiological solution should be added to the specified amount of the drug.

• For children from 2 years of age, Ambrobene can be used instead of Lazolvan for inhalations. The dosages of the drugs are usually the same, but it is better to discuss the replacement with your doctor.
• Pulmicort and Lazolvan for inhalation can also be used together:
  • For children six months and older, it is recommended to use Pulmicort in the amount of 0.25-2 mg/day;
  • Children over 12 years of age and adults are prescribed 0.5-4 mg of Pulmicort per day.

Many patients are interested in whether Lazolvan can be diluted with water for inhalation. Regular drinking water is not used to dilute Lazolvan. It is best to use isotonic sodium chloride solution (aka saline) or water for injection (sold in pharmacies).

Lazolvan for inhalation should not be mixed with products based on cromoglycic acid, with alkaline liquids whose pH exceeds 6.3.

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Inhalations with Lazolvan for children

Lazolvan for inhalation is allowed to be prescribed for cough therapy in pediatrics. Children under 2 years of age are treated only under the supervision of a medical specialist. Inhalation is not allowed if the baby has a fever or a tendency to nosebleeds.

Use Lasolvan for inhalation during pregnancy

It has been found that the basic ingredient of the drug Lazolvan successfully overcomes the placental barrier. And, although scientists have not identified any negative impact on the fetus, it is recommended to avoid treatment with Lazolvan during pregnancy. This recommendation is especially true for the first trimester.

The active ingredient of the drug is found in breast milk, so breastfeeding mothers should not be treated with Lazolvan for inhalation.

Contraindications

Lazolvan solution for inhalation administration is not used to treat patients suffering from increased sensitivity to the substances that make up the drug.

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Side effects Lasolvan for inhalation

Side effects associated with inhalation of Lazolvan are relatively rare. They may be expressed in the form of such undesirable symptoms:

• nausea, decreased sense of taste;
• pain in the abdominal area, dyspepsia;
• rarely – skin rashes such as urticaria.

Allergic reactions to the drug Lazolvan are extremely rare - only isolated cases have been recorded to date.

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Overdose

There have been no cases of overdose with the drug Lazolvan for inhalation recorded to date. It is assumed that signs of overdose may be expressed in increased side effects, which are eliminated by taking symptomatic drugs.

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Interactions with other drugs

Simultaneous treatment with Lazolvan for inhalation and other medications that suppress the cough reflex is not recommended. This is due to the fact that there is an increased risk of excessive accumulation of mucus secretions in the respiratory organs. This combination is possible only after the doctor has carefully weighed the benefits and possible negative consequences.

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Storage conditions

Vials with Lazolvan solution for inhalation can be stored at temperatures from +8 to +25°C. The storage area for medications should be fenced off and inaccessible to children.

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Shelf life

Vials of Lazolvan for inhalation can be stored for up to five years, after which the product should be thrown away.

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Reviews

There are a variety of reviews about Lazolvan for inhalation, and most of them are positive. Parents often note that expectoration and cough relief in a child are observed after just a few procedures. It is also convenient that the solution can be used both by inhalation and internally, which allows you to treat even the most capricious babies.

Side effects are rarely observed during treatment with Lazolvan. As a rule, they develop only when the solution is used incorrectly. To avoid trouble, you must adhere to the following rules:

• During inhalation, the patient should sit, but not lie down;
• the procedure is performed only one and a half hours after eating or physical activity;
• during inhalation, inhale through the mouth, hold your breath for a bit, and exhale through the nose;
• breathing should be even, you should not take too deep breaths;
• If Lazolvan is used to treat asthma, then inhalation is carried out only after taking bronchodilators (to avoid spasms and irritation of the respiratory organs);
• the temperature of the inhalation solution should be approximately equal to the temperature of the human body;
• the inhalation mask is not boiled, but wiped with a disinfectant - for example, hydrogen peroxide;
• inhalation should not be done immediately before going to bed, as this may cause a coughing fit;
• Lazolvan is not suitable for use in steam inhalers.

If you take into account all the above points, then treatment with Lazolvan will only be beneficial.

Patients often look for Lazolvan analogues for inhalation, because this drug is not always available in pharmacies. The most common similar drug is Ambrobene, since it has almost the same composition based on ambroxol hydrochloride. Ambrobene inhalation solution is available in two versions - 0 ml and 100 ml. The drug, as well as Lazolvan, is usually prescribed for pneumonia and bronchi inflammation, obstructions, bronchial asthma. The drug is well accepted by the body and can be used already in the neonatal period.

Other analogues of Lazolvan for injections may be:

• Ambroxol solution (Ukraine, Kharkov);
• Ambroxol-Teva solution (Germany);
• Ambrosan drops (Czech Republic);
• Medox drops (Czech Republic);
• Mukolvan solution (Ukraine);
• Mucosol solution (Lekhim, Ukraine);
• Flavamed and Flavamed Forte solution (Germany);
• Lazolex solution (Ukraine).

What to choose, Lazolvan or Ambrobene for inhalation? Which is better? This choice is not fundamental: both drugs belong to the same therapeutic group and have the same active ingredient, so their effect is equivalent. The only difference is in the manufacturer. The effectiveness of the drugs is the same, which has been proven experimentally more than once.

Berodual or Lazolvan for inhalation? Which is better? It is better to consult a doctor regarding this issue, since we are talking about different types of drugs: Lazolvan is a mucolytic used for coughs and colds, and Berodual is an adrenergic agent for the treatment of respiratory tract obstructions. Berodual should not be used for a common cough: the medication is intended to relieve obstructions in the respiratory tract - for example, its use is justified in asthma, obstructive bronchitis or emphysema. Only a doctor can prescribe such a drug, if there are indications. If the prescription prescribes Lazolvan for inhalation, then independently replacing one solution with another is prohibited.