Ipental

Ipental is an enzyme medication that stimulates digestive function and is used to treat or prevent digestive disorders. The drug supplements natural enzymes in the processes of food digestion.

The composition of the drug contains pancreatin, and its enzyme elements are amylase with protease and lipase, which help to activate the intra-intestinal digestion of carbohydrates, and in addition to proteins with fats, mostly in the intra-alkaline environment of the 12-ductus intestine and the upper region of the small intestine. [1]

Protease helps to divide heavy protein fractions into peptides. Amylase transforms starch into maltose. The effect of lipase contributes to the breakdown of fat, from which glycerin is formed with fatty acids.

Indications Ipental

It is used to treat digestive disorders caused by diseases in the gallbladder or pancreas , as well as the liver.

It is used in situations with gastric digestion disorders, pain, abdominal discomfort and gas formation caused by these disorders. It is prescribed for digestive dysfunctions that occur with poor chewing of food (due to tooth damage), or bloating , after taking fatty or heavy meals and to remove gases before performing an X-ray or sonography of the peritoneum.

Release form

The release of the drug is made in enteric tablets.

Pharmacodynamics

The extract obtained from animal bile (bovine) potentiates the activity of lipase during the breakdown of fats, and at the same time helps to emulsify them; it also stimulates the absorption of fatty acids. The substance is used as a substitute medicine in situations where there is a lack of bile inside the intestine, associated with impaired absorption and digestion of food. Despite the fact that bile does not contain enzymes, it is very important for food digestion. Bile helps to neutralize the chyme leaving the stomach, which has an extremely high acidity to stimulate the activity of pancreatic enzymes. [2]

The extract made from bovine bile is very important in that it helps the absorption of fats (in particular), and in addition to certain vitamins, including menadione with calciferol, and some minerals (Fe and Ca). The ability of the extract to stimulate fat absorption can be explained by emulsification, as well as the formation of conjugated bonds with fatty acids that can dissolve inside intestinal fluids. Together with this, the extract helps in the absorption of cholesterol.

The hemicellulases present in the composition of drugs for the most part help the digestion of hemicellulose. This substance has an optimal effect at the pH range of 3-7, providing a complete digestion of carbohydrates obtained with plant food elements, which contribute to the production of glucose.

Dosing and administration

The selection of the dosage is done personally. Usually Ipental is consumed in the amount of 1-2 tablets 3 times a day, with food or immediately after, while drinking them with plain water. Therapy can last a minimum of several days (in the case of digestive disorders due to an improper nutritional regimen) and a maximum of several months or years (if regular substitution treatment is required).

A child over 6 years old is prescribed to take the 1st tablet 3 times a day.

Before performing an ultrasound or radiological examination, 2 tablets of drugs are used 2-3 times a day (in the period 2-3 days before the procedure).

• Application for children

Ipental is not used in persons under 6 years of age.

Use Ipental during pregnancy

It is forbidden to appoint lactating or pregnant women.

Contraindications

Among the contraindications:

• severe intolerance to the elements of the medication or drugs, which contain enzymes of animal nature;
• intense hepatic pathologies, in which the level of serum bilirubin increases;
• paralysis affecting the ileum;
• obstruction of the biliary tract.

Side effects Ipental

The main side symptoms:

• damage to the digestive function: occasionally (in the case of using large portions), nausea, diarrhea or pain in the abdomen appears;
• signs of allergies: pain in the mouth or in the anus, rashes or redness of the skin, sneezing and watery eyes.

Interactions with other drugs

Before a meal or together with it, it is allowed to take medications that reduce gastric acidity - in order to reduce the deactivation of pancreatin under the influence of gastric acids.

The medicine can be used to increase the absorption of certain therapeutic substances (sulfonamides, PAS, and antibiotics).

Storage conditions

Ipental must be kept in a dark place, closed from the penetration of small children. Temperature values are in the range of 8-25 ° C.

Shelf life

Ipental is allowed to be used within a 24-month period from the date of manufacture of the drug substance.

Analogs

Analogues of drugs are Festal and Enzistal.