Inhalation with Berodual when coughing, temperature and bronchitis: dosage

A popular drug used in the treatment of breathing problems due to bronchospasm is Berodual. Consider the method of its use, dosage.

Berodual deserved recognition from both doctors and patients. It contains effective active ingredients that have a rapid therapeutic effect. It belongs to the pharmacological group of drugs used to treat obstructive respiratory diseases.

The composition of the medication includes two components: ipratropium bromide and fenoterol. Their interaction normalizes the secretion of bronchial glands, improves bronchial drainage, has anti-inflammatory and antispasmodic effect. Both active ingredients have different therapeutic properties, but reinforce each other's effects.

Is berodual available for inhalation?

Berodual has a bronchodilator composition and belongs to beta-adrenoreceptor stimulants. It should be used to treat diseases of the bronchi and lungs in children and adults. The drug is used in the form of inhalation.

The complex composition of the drug provides a comprehensive effect on the lesion. After using the drug, cough attacks decrease, breathing improves and wheezing passes. Berodual belongs to prescription drugs, so it should be used only for medical purposes.

Berodual - hormonal or not?

One of the main advantages of Berodual over other anti-asthma drugs is that it does not contain hormonal components and does not affect the hormonal balance in the patient's body.

The composition of the medication includes such substances:

• Fenoterol - beta-adrenergic, helps relax the smooth muscles of the bronchi and small vessels. Violates the activity of histamines, enhances the function of ciliated epithelium.
• Ipratropium bromide is an atropine derivative with local anticholinergic properties. Prevents narrowing of the bronchus when exposed to tobacco smoke, cold air. Normalizes the functioning of the bronchial glands and their secretion.

Since the drug does not have hormonal properties and begins to act immediately after use, it is safe for pediatric patients. For medical appointments can be used during pregnancy and lactation.

[1], [2], [3], [4], [5]

Indications Beroduala

Berodual is recommended for the treatment and prevention of chronic obstructive airway obstruction:

• Asthma.
• Allergic and endogenous bronchial asthma.
• Chronic obstructive bronchitis with and without emphysema.
• Bronchopulmonary diseases with bronchospasms.
• Hypersensitivity of the bronchi.
• Choking cough of unclear etiology.
• Allergic cough.

Also, the drug is used in the preparation of the respiratory tract for aerosol administration of other medicines: antibiotics, mucolytics, corticosteroids and other means.

When coughing

Drug belongs to bronchodilators. Its active ingredients relax the musculature of the respiratory system. Due to this, Berodual is effective in the symptomatic treatment of both wet and dry cough. The active substances penetrate well into the mucosa of the respiratory system, providing a quick therapeutic effect.

• Ipratropium bromide is included in the group of anticholinergic drugs and affects the smooth muscles of the bronchi. Reduces the severity of the reflex constriction of the bronchi, facilitates breathing.

• Feloterol is an active substance from the group of adrenoreceptors. It improves breathing due to relaxation of the smooth muscles of the bronchi. Especially effective for bronchitis of various etiologies.

The interaction of the components of the drug and their inhalation use, allows you to quickly arrest acute cough attacks of any origin in both children and adults.

[6]

With a wet and dry cough

Beta-adrenoreceptor stimulant is effective in treating various types of cough of wide etiology. That is, Berodual is prescribed for diseases with both dry and wet cough.

The active ingredients of the drug affect the muscles of the respiratory system, remove their increased tone. Reduce the reflex stimulus that enters the cough center of the brain.

The drug relieves spasms in the trachea and bronchi, normalizes the secretion of mucus in the bronchi and expands the bronchial ducts. As a result, the muscles of the respiratory system are relaxed, a coughing fit is reduced, and sputum is removed from the bronchi and trachea.

The bronchi

One of the indications for inhalation with Berodual is the symptomatic treatment of bronchitis, its obstructive and chronic forms.

Bronchitis is an inflammatory lesion of the respiratory system, especially the bronchi. This disease is often a complication of colds and is one of the most frequent causes of seeking medical help.

Berodual is recommended to be used in the complex therapy of bronchitis simultaneously with coughing preparations, mucolytics, antibiotics. Inhalations quickly relieve painful symptoms and speed up the healing process.

The larynx

Inflammation of the mucous membranes of the larynx caused by viral or infectious pathogens is laryngitis. Most often, this disease occurs in children, causing acute damage to the larynx and the initial parts of the trachea.

Berodual is one of the most effective drugs for the treatment of various forms of laryngitis. Its active ingredients facilitate the process of breathing, preventing attacks of suffocation. The dosage and duration of therapy is determined by the attending physician, individually for each patient.

In combination with anti-inflammatory drugs, the drug prevents the development of laryngotracheitis and other complications of the disease.

With asthma

Bronchial asthma is one of the most common respiratory diseases. It manifests itself with periodic attacks of breathlessness, when a person takes a breath and cannot breathe.

One of the methods to eliminate the painful symptoms of asthma is inhalation with Berodual. The instructions of the drug indicated that it can be used in asthmatic pathologies. Inhalation of its active ingredients promotes relaxation of bronchial and vascular smooth muscles, prevents stimulation of bronchoconstriction.

For inhalation, you can use an aerosol can or nebulizer. In the latter case, the drug is diluted with saline solution, so as not to provoke the development of side effects of the drug.

With tracheitis

Tracheitis is a disease of ENT organs with marked inflammatory reactions in the tracheal mucosa. Pathology proceeds with dry, tearful cough, sore throat and sternum pain. If you leave a painful condition without proper treatment, the tracheitis will turn into the form of tracheobronchitis, the treatment of which is more complex and lengthy.

Berodual is an effective inhaled drug that should be used to relieve tracheitis symptoms. It relieves coughing, facilitates breathing, has a combined bronchodilator effect.

Inhalation is recommended using a nebulizer. The solution is mixed with sodium chloride in the proportions prescribed by the doctor. Procedures are carried out 1-2 times a day. The duration of symptomatic therapy should not exceed 5 days.

At a temperature

Inhalation administration of berodual does not imply exposure to the body of hot steam. Proceeding from this, elevated body temperature is not a contraindication for inhalation.

Procedures are prohibited in the event that the temperature is accompanied by an acute fever and causes fainting in a patient. In other cases, treatment relieves painful symptoms, improves breathing and general well-being.

[7], [8], [9]

With pneumonia

Pneumonia is an inflammation of the lung tissue. The disease occurs with cough, chest pain, shortness of breath and difficulty breathing. The basis of her treatment are antibacterial drugs. Also, patients are prescribed symptomatic therapy, for example, inhalation use of drugs that improve the drainage of the bronchopulmonary system.

Berodual for pneumonia effectively relieves spasms of the respiratory organs, dilutes sputum and promotes its discharge. The drug is used for inhalation using a nebulizer. Very often, bronchodilators are combined with mucolytic and other drugs.

With a cold

Runny nose is a symptom of many diseases. One of the most effective methods of its elimination is inhalation with a nebulizer. Berodual has no direct indications for the treatment of rhinitis and is not recommended for use only with this symptom. For treatment, it is better to consult a doctor and pick up safe vasoconstrictor drops, aerosols.

But if snot appeared on the background of acute respiratory viral infections, bronchitis or obstructive airway obstruction, inhalation not only promotes the expansion of the bronchi, but also facilitates nasal breathing.

With allergies

Every day, respiratory diseases caused by allergic components are increasingly diagnosed: acute and chronic bronchitis, bronchial asthma, bronchitis with asthmatic components, allergic rhinitis, and more. The occurrence of these diseases indicates the pathological susceptibility of the body to allergens.

For example, allergic bronchitis occurs with allergy symptoms and acute inflammation in the bronchi. Respiratory lesions develop after contact with a causative factor. Symptoms manifest paroxysmal dry cough with wheezing and subfebrile body temperature. If due to allergens bronchospasm develops, then there is a strong shortness of breath and an acute attack of suffocation.

Such symptoms require emergency treatment. For this it is recommended to use bronchodilator drugs, that is, beta-adrenoreceptor stimulants. This pharmacological group includes Berodual. Inhalation of the drug has such an effect on the body:

• Promotes relaxation of smooth muscles of the bronchi.
• Expands the bronchi and facilitates breathing.
• Prevents the release of mediators inflammation.
• Suppresses bronchospasms caused by various allergens (cold air, tobacco smoke, the smell of household chemicals and more).

Before using the inhalation agent, you should ensure that there are no allergic reactions to its components. The dosage of the drug depends on the individual characteristics of the patient, therefore, is chosen by the attending physician.

Inhalation is carried out using an aerosol spicer or nebulizer. In the first case, 1-2 injections are enough to relieve pathological symptoms. When using a nebulizer, bronchodilators diluted with saline (1-2 ml of the drug in 2-3 ml of sodium chloride) and inhale. Procedures can be carried out up to 3-4 times a day.

For lung cancer

One of the signs of lung cancer is difficulty breathing and airway obstruction. Because of the malignant process, the patient accumulates sputum, which is difficult to cough up. In order to alleviate the pathological condition, inhalations with Berodual are recommended.

The active ingredients of the drug effectively expand the bronchi and improve breathing. Inhalations are carried out 2-3 times a day using a nebulizer or an aerosol can.

[10]

Release form

Berodual has several forms of release:

• Solution
• Drops
• Spray can

Apply solution / drops to the nebulizer. The bottle has a capacity of 2 ml (40 drops). Each milliliter of the drug contains 250 µg ipratropium bromide and 500 µg fenoterol.

The aerosol form is especially popular. Berodual is produced in the form of disposable inhalers 20 ml (200 doses), which are most often prescribed to patients with asthma. The inhaler is convenient to carry and use when a painful attack.

Solution for inhalation

This form of release is one of the most popular. The solution is used for inhalation with a pronounced bronchodilator effect in diseases of the respiratory system. For the procedure using a nebulizer, the mechanism of action of which is based on ultra-low dispersed spraying of the drug substance.

Since Berodual is a potent drug, it is not used in its pure form. A physiological solution of sodium chloride is used for its cultivation. The proportions of all components are determined by the doctor.

[11], [12]

Drops for inhalation

In addition to the solution and aerosol, the drug is available in the form of a dropper bottle of 20 ml. Drops are used for inhalation using a nebulizer. The advantage of the drop form is that it allows you to easily measure the dosage required for treatment. So, adults are prescribed 10 drops per 3-4 ml of saline solution, and for children 2-4 drops per 3-4 ml of sodium chloride.

[13], [14]

Aerosol and spray for inhalation

Berodual aerosol cans are particularly popular with patients. A convenient form of release allows you to carry the drug with you and use when the first painful symptoms appear.

The inhaler gives instant results. The active ingredients of the drug penetrate deep into the respiratory tract and relieve asthma attacks. To relieve painful symptoms, a single injection of medication is enough. Aerosol is used 3-4 times a day.

[15]

Inhalation spacer

One form of drug release is a spacer, that is, a metered-dose aerosol inhaler. The device is a metal can with a metering valve and a mouthpiece. The spacer contains 10 ml of medicine, that is, about 200 doses (injections).

The advantage of the inhaler is that you can always carry it around. The bottle does not take up much space and, if necessary, is at hand. The inhalation route of administration of the aerosol delivers the active ingredients directly to the lesion. Due to this therapeutic effect develops over a short period of time.

The composition of berodual

Berodual contains the following substances: ipratropium bromide, fenoterol hydrobromide and auxiliary components: benzalkonium chloride, sodium edetate, sodium chloride, concentrated hydrochloric acid, purified water. 1 ml of solution contains ipratropium bromide 261 µg and fenoterol hydrobromide 500 µg.

Pharmacodynamics

The composition of the inhalation agent includes two active ingredients, the interaction of which determines the pharmacodynamics of the drug.

• Ipratropium bromide

Quaternary ammonium compound with parasympatholytic properties. Inhibits vagal reflexes, prevents an increase in intracellular Ca ++, arising from the reaction of acetylcholine with smooth muscle muscarinic receptors. When administered by inhalation, it acts on the tissues of the respiratory system, expands the bronchi, facilitates breathing.

• fenoterol hydrobromide

A direct sympathomimetic that selectively stimulates beta 2 -adrenoreceptors. High concentrations of this substance cause stimulation of beta 1-adrenoreceptors. Promotes relaxation of bronchial and vascular smooth muscles. Warns stimulation of bronchoconstriction from cold air and other irritants. It has a local anti-inflammatory effect.

The simultaneous use of two active bronchodilators contributes to the rapid expansion of the bronchi. It has a combined antispasmodic effect on bronchial muscles. This allows the use of Berodual in the treatment of a wide range of diseases of the bronchopulmonary apparatus and airway obstruction.

How does berodual for inhalation? \

Stimulator beta-adrenergic receptors has a combined composition and has the following properties:

• Improves bronchial drainage.
• Stimulates the secretion of bronchial glands.
• It has anti-inflammatory properties.
• Relieves smooth muscle spasms of the respiratory organs.
• Thins the mucous barrier that has accumulated during the spasm.
• Eliminates shortness of breath on exhalation.
• Reduces swelling of the alveoli.

After inhalation, cough is improved, breathing improves and calms down, wheezing disappears. In case of bacterial infection, the medicine is supplemented with antibacterial therapy. Berodual prevents spastic attacks of various etiologies and effectively suppresses local inflammatory processes.

[16], [17]

Pharmacokinetics

The therapeutic effect of Berodual is achieved by its inhalation administration, that is, through a local effect on the respiratory tract. Pharmacokinetics of the drug is based on the pharmacological properties of its active ingredients.

• Fenoterol hydrobromide - a part of this substance is swallowed and metabolizes to sulfate conjugates. Oral bioavailability is about 1.5%. During inhalation, about 1% of the drug is excreted by the kidneys in the form of free fenoterol. The total bioavailability of inhalation doses of fenoterol hydrobromide is 7%.

• Ipratropium bromide - after inhalation use, the cumulative renal excretion of this component is 3-13%. General and systemic bioavailability of 2% and 10-28%. Part of ipratropium bromide is ironed out, which does not affect its systemic effects on the body. The half-life of the drug is about 1.6 hours.

After inhalation, Berodual about 10-39% of the dose taken is deposited in the lungs, and the rest remains in the oral cavity, the upper part of the respiratory tract and on the tip of the inhaler.

[18], [19]

Dosing and administration

Bronchodilating drug is one of the most commonly prescribed for patients with bronchospasm caused by bronchitis, pneumonia, bronchial asthma and other diseases of the bronchopulmonary system.

Inhalations for adults improve breathing and stop coughing seizures, normalize the drainage function of the bronchi and eliminate wheezing. If the disease is caused by a bacterial infection, then the treatment is supplemented with antibacterial therapy. The drug is used regardless of the meal.

If a nebulizer is used for inhalation, the dosage for adults with bronchospasms of various etiologies is 1–2.5 ml of bronchodilator per 3-4 ml of saline. For the prevention of asthma in 0.1-0.2 ml of the drug in 2-3 ml of saline. The duration of treatment depends on the severity of the disease state.

All forms of release of Berodual are intended only for inhalation use, do not use the drug orally. The solution is used with various models of nebulizers. The concentration of active ingredients depends on the power and efficiency of the device.

The dosage and duration of therapy depends on the age of the patient and the indications for use of the drug:

• Adults and children over 12 years old - with bronchospasms of various etiologies, 1–2.5 ml of Berodual per 3-4 ml of saline. For the prevention of asthma in 0.1-0.2 ml of the drug in 2-3 ml of saline.
• Children from 6 to 12 years old - for the treatment of acute asthma attacks, 0.5-2.0 ml per 3-4 ml of saline is used. In other cases, 0.1-0.2 ml of the drug in 2-3 ml of saline.
• Children under 6 years old (body weight less than 22 kg) - 0.1 ml / kg with a dilution of saline to a total volume of 3-4 ml.

Bronchodilator contraindicated diluted with distilled water. The finished solution should be used immediately after preparation. The remnants of the drug are destroyed.

[25]

Berodual for inhalation for children

Bronchodilator is effective in the treatment of respiratory diseases in children. It is prescribed for bronchitis, tracheitis, asthma, laryngitis and other pathologies in which the patient has difficulty breathing due to bronchospasm.

Berodual is prescribed for children aged 6 to 12 years (body weight more than 22 kg). Depending on the age of the child, inhalation is carried out through a nebulizer or using an aerosol spray. The dosage of the drug (0.1 ml / kg) and the duration of its use depend on the severity of the disease state. Very often, the drug is combined with other drugs for a complex effect on the body.

Inhalation with Berodual for children younger than one year is possible only according to strict medical indications. Most often, the drug is prescribed for broncho-obstructive syndrome, which occurs in 30-50% of babies in the first year of life. Inhalations are effective for acute respiratory viral infections, allergic reactions to artificial feeding, coughing and other pathologies.

To relieve an acute condition, Berodual is used with a nebulizer (4-6 drops of the drug with 2 ml of saline). A non-invasive method of delivering bronchodilator components to the body, contributes to the rapid restoration of the patency of the bronchial tree and oxygen saturation in the blood. Berodual can be used as an emergency aid for acute broncho-obstructive syndrome.

Use Beroduala during pregnancy

According to the instructions, Berodual is not recommended for use in the first and third trimester of pregnancy. Its use in the second trimester and in the period of lactation is possible only by medical prescription.

Restrictions on the use of this inhalation agent are related to the fact that fenoterol has an inhibitory effect on the contractile function of the uterus. Because of this, the use of medication in high doses in the later periods of gestation adversely affects the condition of the infant.

Also fenoterol hydrobromide penetrates into breast milk. When prescribing medication for lactating women, the doctor can stop breastfeeding during treatment. In this case, both active ingredients do not affect the fertility of the patient.

Contraindications

Like any drug, Berodual has a number of contraindications. Inhalations are not carried out with individual intolerance to fenoterol hydrobromide, atropine-like substances, or other components of the preparation. Bronchodilator is prohibited for patients with tachyarrhythmia and hypertrophic obstructive cardiomyopathy.

It is prescribed with special care in case of angle-closure glaucoma, diabetes mellitus, diseases of the cardiovascular system, arterial hypertension, coronary artery disease and heart defects.

Only according to strict medical indications with an assessment of the potential benefits is used for hyperthyroidism, prostatic hyperplasia, cystic fibrosis, bladder neck obstruction, during pregnancy and lactation.

[20], [21]

Side effects Beroduala

Despite the wide range of medicinal properties, Berodual can cause many adverse reactions:

• Increased systolic and lower diastolic pressure.
• Supraventricular tachycardia.
• Decreased potassium in the blood.
• Swelling of the mouth.
• Angioedema.
• Stomatitis.
• Delay urination.
• General weakness, headaches and dizziness.
• Excessive perspiration.
• Skin allergic reactions.
• Temporary visual acuity.
• Violation of intestinal motility.

Most often, the inhaler causes irritation of the mucous membranes of the respiratory system, causing dryness in the mouth. Also, many patients report light tremor of the extremities during Berodual therapy.

[22], [23]

Addiction to berodual

According to the research and pharmacological properties of the drug, Berodual is not capable of causing dependence. But despite this, many patients note a decrease in its effectiveness with long-term use, that is, they indicate the development of addiction.

The main signs of addiction include:

• Cessation of relief of breathing.
• Coughing seizures during inhalation.
• Pain in the bronchi and lungs.

If the above symptoms appear, it is recommended that the drug be withdrawn. In this case, increasing the dosage of Berodual is not only ineffective, but also dangerous. Alternatively, use drugs-analogues with a similar mechanism of action. After a certain time, the patient can start taking bronchodilators again.

[24]

Overdose

The severity of symptoms of overdose depends on the duration of receiving higher doses of the drug. Most often, patients are faced with such painful reactions:

• Slight dizziness and hot flashes.
• Headache.
• Cardiopalmus.
• Anxiety.
• Chest pain.
• Tremor of the limbs.
• Nausea and vomiting.
• Hyperglycemia / Hypokalemia.
• Metabolic acidosis.
• Dry mouth.

For treatment, the abolition of the drug, monitoring of acid-base and electrolytic balance is shown. In severe cases, intensive care is carried out with the management of tranquilizers and hospitalization.

[26], [27], [28],

Interactions with other drugs

The successful treatment of any disease involves the use of several drugs that have a comprehensive therapeutic effect. Particular attention in drawing up a scheme of such treatment is given to the interaction of all drugs. Berodual is often prescribed in combination with other medications that can both enhance the effect of each other, and vice versa inhibit.

Increased therapeutic effect and increased risk of adverse reactions is possible when Berodual interacts with such drugs:

• Other beta adrenergic and anticholinergic agents (all routes of administration).
• Xanthine derivatives.
• Anti-inflammatory drugs, corticosteroids.
• MAO inhibitors.
• Tricyclic antidepressants.

A decrease in the therapeutic effect is observed when used with beta-blockers. For patients with endocrine pathologies, it should be borne in mind that inhalations reduce the hypoglycemic effect of antidiabetic drugs.

What will happen if you drink berodual?

If the patient accidentally drank Berodual intended for inhalation, then the first thing to do is flush the stomach or try to induce vomiting. Also shown is the reception of activated carbon at the rate of 1 tablet per 10 kg of patient weight.

In most cases, oral administration of the bronchus beta2-adrenoreceptor stimulator does not cause acute symptoms. But if there was a tremor of the limbs, a sharp deterioration in general well-being and other pathological signs, you should immediately call an ambulance.

[29], [30], [31]

Storage conditions

All forms of release of Berodual should be stored in the original packaging protected from sunlight, moisture and inaccessible to children. The optimum storage temperature is not higher than 25 ° C. Violation of these conditions may lead to premature deterioration of the drug.

[32]

Shelf life

According to the instructions, the inhalation agent must be used within 36 months from the date of its manufacture. Production date is indicated on the product packaging. Opened Berodual vials, subject to the conditions of their storage, can be used until the end of the official expiration date. It should also be borne in mind that the medication is dispensed only by medical prescription.

Reviews

According to numerous reviews of patients, Berodual has established itself in the treatment of a wide range of pathologies of the respiratory system. Inhalation with the use of saline is effective for inflammation of the upper and lower respiratory tract, bronchial asthma, obstructive bronchitis.

The drug has a bronchodilator effect in allergic reactions, bronchospasms and serious respiratory disorders. A couple of breaths of medication expands the bronchi, normalizes the production of a secret, improving the general condition of the patient.

Complex inhalation therapy enjoys considerable popularity when, in addition to the bronchodilator, mucolytic drugs and other pharmaceutical groups are used. Due to this, the healing process is much faster.