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Ibuklin
Last reviewed: 03.07.2025

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Ibuclin is a typical representative of a group of drugs called non-steroidal anti-inflammatory drugs. According to the international classification, the drug belongs to anti-inflammatory and antirheumatic drugs, which are derivatives of ibuprofen and its combinations.
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Indications Ibuklin
Due to its complex composition, the drug has a wide range of effects, which ensures its use in many areas of medicine.
Thus, the indications for the use of Ibuclin include severe hyperthermia, and the fever can have different genesis of origin. These can be both colds and more serious infectious diseases with severe inflammation.
Ibuclin copes well with pain syndrome, but its degree should not be excessively high. The drug relieves moderate pain in the presence of an inflammatory focus in the bones, joints and muscles, for example, with gouty or rheumatoid arthritis, ankylosing spondylitis.
Indications for the use of Ibuclin in the fight against pain syndrome are represented by degenerative processes in joints and bone structures in deforming osteoarthrosis and osteochondrosis.
The drug is effective in tendovaginitis and bursitis, when the periarticular capsule is involved in the process. Lumbago, neuralgia, muscle pain, as well as post-traumatic injuries in dislocations, sprains, fractures and bruises are also grounds for using Ibuclin.
Some of the most common uses include headaches, toothaches and joint pain.
Release form
The main characteristics of this pharmaceutical product are its release form, which is represented by a tablet preparation, and its physical and chemical properties. They include the coating of each tablet with a film coating, the shade of which varies from light orange to a more saturated color.
It is also worth highlighting the capsule-like shape, which has a dividing strip on one side and a smooth surface on the other.
The release form in the form of tablets determines the packaging of the drug. Thus, Ibuclin is packed with 10 tablets in one blister, which corresponds to one cardboard package.
Each tablet contains 400 mg of ibuprofen and 323 mg of paracetamol. In addition to the main components, there are several additional ones, such as cellulose, starch, glycerin and others.
The tablet form is very convenient to use, since due to the specific composition of each tablet, you can strictly monitor the dosage and avoid overdose.
Pharmacodynamics
The pharmacodynamic properties are determined by the main components of the drug – ibuprofen and paracetamol.
Each of the above components has certain capabilities, which, in combination with another component, provides a pronounced therapeutic effect.
The pharmacodynamics of Ibuclin is a complex of actions of both drugs, which have an analgesic and anti-inflammatory effect. By blocking cyclooxygenases, the drug not only reduces the manifestations of the inflammatory reaction, but also acts as an antipyretic.
As for paracetamol, it is not capable of exerting a pronounced anti-inflammatory effect on its own, since its activity is inhibited by peroxidases. As a result, Ibuclin additionally contains ibuprofen to enhance the therapeutic effect.
The components of the drug, having a combined effect, provide a reduction in pain in the joints, which in turn leads to a decrease in stiffness in motor activity and returns the previous mobility of the joint.
Pharmacokinetics
The complex drug consists of two main active medicinal agents, therefore the pharmacokinetics of Ibuclin is based on the combined action of both components.
Thus, ibuprofen penetrates into the general bloodstream quite quickly through the mucous membrane of the digestive organs after oral use. Its maximum concentration in plasma is observed after a couple of hours.
Almost 99% of ibuprofen binds to plasma proteins, with which it is carried through the bloodstream. Ibuprofen is eliminated by filtration by the kidneys in unchanged form or as oxidized metabolites in an inactive form.
In the above-mentioned ways, all ibuprofen metabolites are eliminated from the body within 24 hours, and after 24 hours the person is completely free of the drug.
The pharmacokinetics of Ibuclin, which includes paracetamol, is due to good absorption. Half an hour after taking the tableted drug orally, the concentration of paracetamol in the bloodstream reaches its maximum value. This level is maintained for 4 hours and gradually begins to decrease.
As for the connection with blood proteins, paracetamol is transported in a complex with them only in a partial amount (approximately 25%). After 1.5-2 hours, only half of the dose taken remains in the human body. Metabolism occurs in the liver with the formation of glucuronides and sulfates. Paracetamol is excreted by the kidneys, gradually decreasing the concentration in the blood and increasing in the urine.
Dosing and administration
The tablet form of the medicine is intended to be taken orally a couple of hours before or after meals. The tablet should not be chewed and should be swallowed whole with a few sips of water.
The method of administration and dosage of medications are selected individually, taking into account the degree of illness, age and health status of the person.
Since children under 12 years of age do not have permission to take this drug, then at an older age and adults can use it 1 tablet up to 3 times a day. It is necessary to observe a certain interval between taking the medication, which should not be less than 4 hours.
It should be noted that a single dose of the tablet drug Ibuclin is a maximum of 2 tablets, and for a daily dosage - a maximum of 6 tablets.
The method of administration and dosage should be adjusted in elderly people, as well as in the presence of concomitant severe pathology. Thus, they should have a break between doses of the drug of at least 8 hours.
Without a doctor’s supervision, the use of Ibuclin as an antipyretic drug is approximately 3 days, and as a pain reliever – no more than 5 days.
If the drug Ibuclin needs to be taken for a long time, then the functioning of the liver, kidneys and the state of the circulatory system should be monitored using laboratory research methods.
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Use Ibuklin during pregnancy
During the entire period of pregnancy and after childbirth, when the baby is breastfed, any medication should be taken under the supervision of a doctor. This is due to the high probability of the drug getting to the child.
The use of Ibuclin during pregnancy is permitted if the benefit to the expectant mother is significantly higher than the harm to the fetus. During the experiments, it was concluded that Ibuclin is not capable of exerting a mutagenic or teratogenic effect.
Despite this fact, it is still not recommended to take the drug for a long period of time during pregnancy and after childbirth.
It is especially necessary to use medications with caution in the first trimester of pregnancy, when the gradual formation of fetal organs is observed. Later, their formation and development occurs.
The use of Ibuclin during pregnancy usually does not cause harm to the woman and the fetus, but it is necessary to strictly control the dosage and duration of taking the drug to avoid negative effects on the fetus.
Contraindications
In order for the drug to have a therapeutic effect without the occurrence of side effects and worsening of the condition, it is necessary to know the contraindications for the use of Ibuclin.
These include the age of children under 12 years, individual characteristics of the body, when the response to the introduction of a certain medicinal component is genetically determined. Also, contraindications to the use of Ibuclin include the presence of ulcerative defects of the mucous membrane of the digestive organs and bleeding in the acute phase.
It is not recommended to take Ibuclin in case of renal failure in the decompensation stage, in case of combined pathology of the paranasal sinuses with bronchial asthma, polyposis and allergic reaction to acetylsalicylic acid.
In addition, Ibuclin is not recommended for use in cases of damage to the optic nerve, pathology of the circulatory system, in the early period after coronary artery bypass grafting, as well as in cases of severe liver pathology, inflammatory bowel diseases and increased amounts of potassium in the blood.
In addition to absolute contraindications, there are also relative contraindications, which include metabolic pathology, heart disease, vascular disorders, simultaneous use of hormones, anticoagulants, antiplatelet agents and NSAIDs.
Monitoring is necessary when taking Ibuclin over a long period of time.
Side effects Ibuklin
The main side effects of Ibuclin, as in many other cases of taking medications, are allergic reactions. They can manifest themselves in connection with the individual characteristics of the body's immunity. As a result, a powerful response of the immune system is possible to oral administration of the drug, manifested by various clinical symptoms.
Most often, one can observe a rash of various diameters and shapes, a tingling sensation, itching, up to the development of urticaria and Quincke's edema. In addition, manifestations can include pain in the stomach and abdomen, nausea, mild dizziness, vomiting, headache and visual impairment.
Side effects of Ibuclin may also include impaired renal function, the appearance of erosive lesions of the mucous membrane of the digestive organs and changes in the blood picture with a decrease in the number of platelets, erythrocytes, changes in the size of blood cells, hyperkalemia, hyperuricosuria and azotemia.
If you experience pain in the stomach and vomiting, you need to monitor the color of the vomit. If it resembles "coffee grounds", then you need to call an ambulance immediately. These symptoms signal the onset of gastric bleeding.
In addition, bleeding from the intestinal sections is indicated by the appearance of blood in the feces (the so-called melena). Such a condition also requires immediate medical intervention.
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Overdose
In case the dosage and duration of administration are not observed, the probability of overdose development increases. In such a case, certain non-specific symptoms can be used to suspect the effect of accumulation of the drug and the increase of its side effects.
Overdose of Ibuclin may manifest itself in the form of digestive disorders with nausea, vomiting and pain in the epigastric zone. Clinical signs of hepatotoxic syndrome, impaired consciousness, headache, decreased blood pressure and pale skin are also possible.
If you observe such symptoms, it is necessary to carry out certain procedures that will remove metabolites and drug residues.
So, first you need to wash out the stomach so that part of the medicine that has not yet been absorbed can be removed from the body. In addition, you need to take activated carbon, which is a sorbent. It will also help block further entry of the drug into the bloodstream.
Overdose in some cases requires hemodialysis and monitoring of the blood picture. In case of electrolyte imbalance, the deficiency should be replenished and the indicators should be normalized.
Interactions with other drugs
People who abuse alcoholic beverages should not use Ibuclin at the same time, as the risk of liver damage increases.
The interaction of Ibuclin with other drugs, for example, those affecting the coagulation system, is undesirable, as it increases the risk of erosive damage to the mucous membrane of the digestive tract and the development of bleeding.
When taking Ibuclin with digoxin, the concentration of the latter medication may increase in the blood. In addition, Ibuclin can potentiate the therapeutic activity of insulin and oral medications that affect blood sugar levels.
The interaction of Ibuclin with other drugs, such as colchicine, methotrexate, probenecid, lithium and gold preparations, can provoke an increase in the manifestation of toxicity of the listed drugs.
When taken together with diuretics, their effect (diuretic, natriuretic, antihypertensive) is reduced. Long-term use in parallel with paracetamol can lead to the appearance of clinical symptoms of kidney damage.
Storage conditions
When producing a medicinal product, the manufacturer must indicate in the instructions the storage conditions due to which the medicinal product retains certain therapeutic properties over a certain period of time.
The storage conditions of Ibuclin require maintaining a temperature regime without sharp fluctuations, humidity and lighting. Thus, the temperature of the room where the medicine is supposed to be stored should not be higher than 25 degrees. Higher values can disrupt the structure of the drug and make it harmful to humans before the expiration date.
The place where the medicine will be stored during the expiration date should not be excessively exposed to sunlight, which is also unacceptable for storage.
Storage conditions of Ibuclin provide for the inaccessibility of the baby to the location of the medicine. Its use may be complicated by laryngospasm or poisoning, which is unacceptable in childhood.
Special instructions
Ibuclin, due to its composition of several main components, is a combination drug. Its main components are ibuprofen and paracetamol.
The first is able to reduce the intensity of the inflammatory reaction, thereby reducing the severity of hyperemia, swelling and pain syndrome. In addition, it has antipyretic properties.
Its mechanism of action is based on inhibition of cyclooxygenase 1,2 activity and disruption of arachidonic acid conversion. The amount of prostaglandins, which are mediators of the inflammatory reaction with the formation of hyperthermia and painful sensations, is also reduced. Similar phenomena are observed in the lesion and healthy tissues, where the exudative and proliferative inflammatory stage is suppressed.
In turn, paracetamol, by blocking COX in the structures of the central nervous system, has a lesser effect on the exchange of water and microelements, as well as the gastric mucosa.
As a result, an analgesic and antipyretic effect is observed, and to a small extent, an anti-inflammatory effect. In combination with ibuprofen, the drug has an analgesic effect, thereby reducing stiffness when moving in the morning, swelling around the joints and restoring physical activity.
Shelf life
In addition to storage conditions, the expiration date must be observed, after which the drug loses its positive effects and becomes harmful to the human body.
The shelf life implies the preservation of the therapeutic effect of the drug, provided that the rules for its storage are observed. Ibuclin can be useful for 5 years, starting from the date of its production.
The manufacturer usually indicates the date on the outside of the cardboard packaging for quicker access, and also on each blister so that if the box is lost, the expiration date can be accessed by a person.
Attention!
To simplify the perception of information, this instruction for use of the drug "Ibuklin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.