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Enterofuril
Last reviewed: 10.08.2022
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Enterofuril is a drug from the group of antimicrobials; used in the treatment of intestinal infections.
The component nifuroxazide is an antimicrobial substance, a derivative of nitrofuran. In therapeutic portions, nifuroxazide almost does not inhibit healthy intestinal microflora, does not lead to the appearance of resistant bacterial forms, and besides, it does not cause cross-resistance of microbes against other antibacterial drugs. The medicinal effect develops already in the first hours after the start of therapy.[1]
Indications Enterofuril
It is used for acute diarrhea of an infectious nature.
Release form
The release of the therapeutic substance is realized in capsules with a volume of 0.1 (10 pieces inside a cell pack, 3 packs inside a box) and 0.2 g (8 capsules inside a blister pack, 1-2 packs inside a box).
Pharmacodynamics
The principle of the medicinal effect is not fully defined. The antiparasitic and antimicrobial activity of nifuroxazide may be related to the presence of an amino group. Local action without penetration into tissues and organs makes nifuroxazide unique in comparison with other derivatives of nitrofuran, since this antidiarrheal drug does not have a systemic effect.
Enterofuril demonstrates the effect of relatively gram-negative and -positive microbes: Staphylococcus aureus, Shigella, pyogenic streptococcus, Salmonella and Escherichia coli.
Pharmacokinetics
When taken orally, nifuroxazide is almost not absorbed in the gastrointestinal tract and does not pass into tissues with organs, 99% of the drug remains in the intestine.
The metabolic processes of nifuroxazide are realized inside the intestine, approximately 20% of the substance is excreted unchanged.
Nifuroxazide with its metabolic products are excreted along with feces. The rate of excretion is determined by the amount of drug used and gastrointestinal motility. In general, the excretion of nifuroxazide is rather slow, the component remains inside the gastrointestinal tract for a long time.
Dosing and administration
Capsules must be taken orally, without reference to food intake.
For adolescents from 15 years old and adults: 0.2 g (1 capsule with a volume of 0.2 g or 2 capsules with a volume of 0.1 g), 4 times a day. It is allowed to use no more than 0.8 g of nifuroxazide per day.
Children over 6 years of age: 2 capsules with a volume of 0.1 g, 3-4 times a day. A maximum of 0.6-0.8 g of nifuroxazide can be taken per day.
Therapy can last a maximum of 7 days (release form 0.1 g) or 3 days (release form 0.2 g).
- Application for children
The drug in the form of a release of 0.1 g is prescribed for children over the age of 6 (a suspension of the drug is used for a child under this age). 0.2 g capsules can be used in adolescents over the age of 15.
Use Enterofuril during pregnancy
There is no reliable information regarding the possible fetotoxic and teratogenic effects when using nifuroxazide in pregnant women. Because of this, the drug is not prescribed during the specified period.
Enterofuril can be used for short-term therapy for hepatitis B.
Contraindications
It is contraindicated to prescribe in case of severe intolerance to nifuroxazide, other derivatives of 5-nitrofuran or other elements of the drug.
Side effects Enterofuril
Temporary abdominal pain and vomiting with nausea or increased diarrhea may occur.
Signs of allergy may develop, including urticaria, anaphylaxis, itching, Quincke's edema and epidermal rash. If allergic symptoms appear, the medication should be discontinued. Further, the patient should avoid the use of nifuroxazide and other nitrofuran derivatives.
Overdose
In case of overdose, gastric lavage and symptomatic procedures should be performed.
Interactions with other drugs
It is forbidden to use nifuroxazide in combination with substances containing alcohol, sorbents, drugs that can provoke an antabuse effect, and agents that suppress the activity of the central nervous system.
Storage conditions
Enterofuril should be kept out of the reach of small children, at temperatures no more than 30 ° C.
Shelf life
Enterofuril can be used within a 5-year term from the date of manufacture of the medicinal product.
Analogs
Analogues of the drug are Ersefuril, Adisord with Nifural, as well as Ekofuril and Stopdiar.
Attention!
To simplify the perception of information, this instruction for use of the drug "Enterofuril" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.