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Enterofuryl
Last reviewed: 04.07.2025
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Enterofuril is a drug from the antimicrobial group; it is used in the treatment of intestinal infections.
The component nifuroxazide is an antimicrobial substance, a nitrofuran derivative. In therapeutic doses, nifuroxazide hardly suppresses healthy intestinal microflora, does not lead to the emergence of resistant bacterial forms, and in addition does not cause cross-resistance of microbes to other antibacterial drugs. The medicinal effect develops already in the first hours after the start of therapy. [ 1 ]
Indications Enterofuryl
It is used for acute diarrhea of infectious origin.
Release form
The therapeutic substance is released in capsules of 0.1 (10 pieces inside a cell pack, 3 packs inside a box) and 0.2 g (8 capsules inside a blister pack, 1-2 packs inside a box).
Pharmacodynamics
The principle of medicinal action has not been fully determined. The antiparasitic and antimicrobial activity of nifuroxazide may be associated with the presence of an amino group. Local action without penetration into tissues and organs makes nifuroxazide unique in comparison with other nitrofuran derivatives, since this antidiarrheal drug does not have a systemic effect.
Enterofuril demonstrates the effect of relatively gram-negative and -positive microbes: Staphylococcus aureus, Shigella, pyogenic streptococcus, Salmonella and Escherichia coli.
Pharmacokinetics
When taken orally, nifuroxazide is almost not absorbed in the gastrointestinal tract and does not pass into tissues and organs; 99% of the drug remains in the intestines.
The metabolic processes of nifuroxazide occur in the intestines; approximately 20% of the substance is excreted unchanged.
Nifuroxazide and its metabolic products are excreted with feces. The excretion rate is determined by the amount of the drug used and the motility of the gastrointestinal tract. In general, the excretion of nifuroxazide is quite slow, the component remains in the gastrointestinal tract for a long time.
Dosing and administration
The capsules should be taken orally, without regard to food intake.
For adolescents aged 15 years and over and adults: 0.2 g (1 capsule of 0.2 g or 2 capsules of 0.1 g), 4 times a day. No more than 0.8 g of nifuroxazide may be taken per day.
Children over 6 years of age: 2 capsules of 0.1 g, 3-4 times a day. A maximum of 0.6-0.8 g of nifuroxazide can be taken per day.
Therapy can last a maximum of 7 days (0.1 g dosage form) or 3 days (0.2 g dosage form).
- Application for children
The medicine in the form of 0.1 g is prescribed for children over 6 years of age (a suspension of the medicine is used for a child under this age). Capsules with a volume of 0.2 g can be used in adolescents over 15 years of age.
Use Enterofuryl during pregnancy
There is no reliable information regarding the possible fetotoxic and teratogenic effects of nifuroxazide use in pregnant women. For this reason, the drug is not prescribed during this period.
Enterofuril can be used for short-term therapy during breastfeeding.
Contraindications
Contraindicated for use in cases of severe intolerance to nifuroxazide, other derivatives of 5-nitrofuran or other components of the drug.
Side effects Enterofuryl
Temporary abdominal pain and vomiting with nausea or worsening diarrhea may occur.
Signs of allergy may develop, including urticaria, anaphylaxis, itching, Quincke's edema, and epidermal rash. If allergic symptoms occur, the drug should be discontinued. The patient should then avoid using nifuroxazide and other nitrofuran derivatives.
Overdose
In case of overdose, gastric lavage and symptomatic procedures must be performed.
Interactions with other drugs
Nifuroxazide is prohibited to be used in combination with substances containing alcohol, sorbents, drugs that can provoke an antabuse effect, and agents that suppress the activity of the central nervous system.
Storage conditions
Enterofuril should be stored in a place out of reach of small children, at a temperature of no more than 30°C.
Shelf life
Enterofuril can be used within a 5-year period from the date of manufacture of the medicinal product.
Analogues
Analogues of the drug are Ersefuril, Adisord with Nifural, as well as Ecofuril and Stopdiar.
Attention!
To simplify the perception of information, this instruction for use of the drug "Enterofuryl" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.