Diseases of the blood (hematology)

Protein Deficiency Z: Causes, Symptoms, Diagnosis, Treatment

Protein Z is a vitamin K-dependent protein that functions as a cofactor of the process of inhibiting blood clotting by forming a complex with a plasma protein, a Z-dependent protease inhibitor.

Protein Deficiency C: Causes, Symptoms, Diagnosis, Treatment

Since activated protein C leads to the breakdown of factors Va and VIIIa, it is thus a natural plasma anticoagulant. Decreased protein C as a result of genetic or acquired causes provokes the emergence of venous thrombosis.

V Factor Resistance to Activated Protein C: Causes, Symptoms, Diagnosis, Treatment

The activated protein C cleaves the factors Va and VIIIa, thereby inhibiting the clotting process. Any of several mutations of factor V causes its resistance to activated protein C, thereby increasing the tendency to thrombosis. The most common factor V mutation is the Leyden mutation. Homozygous mutations to a greater extent increase the risk of thrombosis than heterozygous.

Thrombophilia: causes, symptoms, diagnosis, treatment

In healthy people, the hemostatic balance is the result of the interaction of procoagulant (clot-promoting), anticoagulant and fibrinolytic components.

Von Willebrand's disease in adults

Von Willebrand disease is a congenital deficiency of vWF, which leads to platelet dysfunction. It is usually characterized by mild bleeding. Screening shows an increase in bleeding time, a normal number of platelets and, possibly, a slight increase in partial thromboplastin time.

Thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome

Thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome are acute, fulminant diseases characterized by the development of thrombocytopenia and microangiopathic hemolytic anemia.

Idiopathic thrombocytopenic purpura in adults

Idiopathic (immune) thrombocytopenic purpura is a hemorrhagic disease caused by thrombocytopenia, not associated with a systemic disease. It usually has a chronic course in adults, but is often acute and transient in children. Spleen size is normal.

Hereditary intracellular disturbances of platelets: causes, symptoms, diagnosis, treatment

Hereditary intracellular disturbances of platelets are rare diseases and lead to the manifestation of bleeding throughout life. The diagnosis is confirmed by the study of platelet aggregation. In the presence of severe manifestations of bleeding, transfusion of platelets is necessary.

Acquired platelet dysfunction: causes, symptoms, diagnosis, treatment

Acquired platelet dysfunction may be the result of taking aspirin, other non-steroidal anti-inflammatory drugs, or systemic diseases.

Thrombocytopenia and platelet dysfunction

Platelets are fragments of megakaryocytes that provide hemostasis of circulating blood. Thrombopoietin is synthesized by the liver in response to a decrease in the number of bone marrow megakaryocytes and circulating platelets and stimulates the bone marrow to the synthesis of platelets from megakaryocytes.

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