Diseases of the blood (hematology)

Senile purpura: causes, symptoms, diagnosis, treatment

Senile purpura leads to the appearance of ecchymoses and is the result of increased fragility of the vessels caused by damage to the connective tissue of the skin caused by chronic insolation and age.

Simple purpura: causes, symptoms, diagnosis, treatment

Simple purple - increased formation of hematomas, resulting from the fragility of the vessels. Simple purple is extremely common. The cause and mechanism of this pathology are unknown. It can manifest itself in various diseases.

Congenital hemorrhagic telangiectasia (Rundu-Osler-Weber Syndrome)

Congenital hemorrhagic telangiectasia (Randu-Osler-Weber Syndrome) is a hereditary disease with vascular disruption, which is inherited in an autosomal dominant type and is found in both men and women.

Rare diseases, accompanied by bleeding

Bleeding can be the result of platelet abnormality, coagulation factors and blood vessels. Diseases of the bleeding of the vessels are caused by the pathology of the vascular wall and are usually manifested by petechiae, purpura, but rarely cause serious bleeding.

Hemophilia: causes, symptoms, diagnosis, treatment

Hemophilia is usually a congenital disease caused by deficiency of factors VIII or IX. The severity of factor deficiency determines the likelihood of development and severity of bleeding. Bleeding in soft tissues or joints usually develops within a few hours of trauma.

The syndrome of disseminated intravascular coagulation (ICD): causes, symptoms, diagnosis, treatment

The syndrome of disseminated intravascular coagulation (ICE, consumption coagulopathy, defibrillation syndrome) is a disorder with pronounced generation of thrombin and fibrin in the circulating blood.

Coagulation disorders due to circulating anticoagulants: causes, symptoms, diagnosis, treatment

Circulating anticoagulants are usually represented by autoantibodies that neutralize specific clotting factors in vivo (eg, autoantibodies against Factors VIII and V) or inhibit protein-bound phospholipids in vitro. Sometimes a late type of auto-antibody causes bleeding in vivo, binding prothrombin.

Violation of blood clotting

Pathological bleeding may occur as a result of diseases of the blood coagulation system, platelets or blood vessels. Coagulation disorders can be acquired or congenital.

Hyperhomocysteinemia: causes, symptoms, diagnosis, treatment

Hyperhomocysteinemia may contribute to the development of arterial or venous thromboembolism, which may be due to damage to the vascular wall endothelial cells. The level of plasma homocysteine increases more than 10 times in homozygotes with a deficiency of cystathionine synthase.

Deficiency of antithrombin: causes, symptoms, diagnosis, treatment

Antithrombin is a protein that inhibits thrombin and factors Xa, IXa, Xla. The prevalence of heterozygous deficiency of plasma antithrombin is from 0.2 to 0.4%. Venous thromboses develop in half of heterozygotic individuals.

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