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Hyperplenism: causes, symptoms, diagnosis, treatment
Last reviewed: 23.04.2024
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Treatment of the hypersplenism
Treatment is aimed at the underlying disease. However, if hypersplenism is the single most serious manifestation of the disease (eg, Gaucher's disease), ablation of the spleen can be indicated by splenectomy or radiotherapy. Since the intact spleen has protective functions against infections with encapsulated bacteria, splenectomy should be avoided, if possible, and patients subjected to splenectomy should be vaccinated against infections caused by Streptociccus pneumoniae, Neisseria meningitidis, Haemophilus influenzae. After splenectomy, patients are especially sensitive to the development of severe sepsis, so when developing fever, such patients should be examined by a doctor with the appointment of empirical antibiotic therapy.
Indications for splenectomy or radiation therapy for hypersplenism
Indications |
Example |
Hemolytic syndrome, in which the shortened survival rate of erythrocytes with intracellular disorders is further reduced due to splenomegaly |
Congenital spherocytosis, thalassemia |
Pronounced pancytopenia against a background of massive splenomegaly |
Lipid accumulation diseases (spleen size can be 30 times normal) |
Vascular Stroke with Spleen Involvement |
Recurrent infarcts, bleeding from varicose veins of the esophagus, associated with intensive venous return of the spleen |
Mechanical trauma of other abdominal organs |
Stomach with early saturation, left kidney with obstruction of calyces |
Severe bleeding |
Hyperplenic thrombocytopenia |