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Antithrombin deficiency: causes, symptoms, diagnosis, treatment
Last reviewed: 07.07.2025
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Antithrombin is a protein that inhibits thrombin and factors Xa, IXa, Xla.
Epidemiology
The prevalence of heterozygous plasma antithrombin deficiency is 0.2 to 0.4%. Half of heterozygous individuals develop venous thrombosis. Homozygous deficiency results in fetal death in utero. Acquired deficiency occurs in patients with DIC, liver disease, nephrotic syndrome, and during heparin or L-asparaginase therapy.
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Treatment antithrombin deficiency
Oral warfarin is used to prevent venous thromboembolism in antithrombin deficiency.
More information of the treatment