Violation of blood clotting
Last reviewed: 17.10.2021
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Pathological bleeding may occur as a result of diseases of the blood coagulation system, platelets or blood vessels. Coagulation disorders can be acquired or congenital.
The main causes of acquired coagulopathy are vitamin K deficiency, liver disease, disseminated intravascular coagulation and the development of anticoagulants. Severe liver diseases (eg, cirrhosis, fulminant hepatitis, acute fatty hepatosis of pregnant women) can disrupt hemostasis, damaging the synthesis of clotting factors. Since all clotting factors are produced by the liver, in severe liver diseases there is an increase in both partial thromboplastin time and prothrombin time (the latter is usually expressed as MHO). Sometimes decompensated liver disease can cause intense fibrinolysis and bleeding may be due to a decrease in liver synthesis of a 2- antiplasmin.
The most frequent hereditary disease of the hemostasis system is Willebrand disease. The most common hereditary diseases of plasma coagulation of the blood are hemophilia.
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