Dazolik

In the world, there are more than fifty types of protozoan microorganisms that can provoke disease in humans. The scale of the defeat of such infections is quite wide: at least one in ten people is the carrier of protozoal infection.

 One of the drugs that suppress the vital activity of protozoa is Dazolik.

Indications Dazolik

The effect of the drug Dazolik is effective against amoebas, trichomonads, obligate anaerobic bacteria, lamblia and individual gram-positive microbes. These microorganisms cause the following diseases, which are indications for the appointment of Dazolik:

• amoebiasis - intestinal and extraintestinal manifestations of amoebiasis, various forms of amoebic dysentery, amoebic disease involving the liver process (abscessing);
• trichomoniasis is a common infection that is transmitted through the sexual organs of partners;
• giardiasis;
• manifestations of bacterial vaginosis;
• anaerobic infections, formed due to abdominal operations on the abdominal organs, or for the prevention of such.

Release form

Dazolik is available in the form of rounded, convex on both sides, smoothed around the edges of tablets. The tablets are protected with a light colored coating and have a dividing line to reduce the dosage on one side. The composition of one tablet - 0.5 g of active ingredient of ornidazole.

The accompanying components of the preparation are elements of microcrystalline cellulose, starch particles, purified talc, compounds of silicon dioxide, magnesium stearate, polyethylene glycol, etc.

Pharmacodynamics

Dazolik has an antimicrobial and antiprotozoal effect, toxic effects on the microbial cell and interferes with respiratory processes of bacterial cells.

The effect of the drug is determined by the possibility of reducing the nitro group of the molecule of the active substance. This process is due to the activity of bacterial enzymes, resulting in the formation of complex compounds of the reduced nitro group and bacterial DNA. As a consequence, the processes of self-healing of DNA cells and RNA biosynthesis are violated.

The data of scientific research allow us to speak with confidence about the bactericidal and bacteriostatic efficacy of the drug.

Pharmacokinetics

Ornidazole is an active substance of the drug Dazolik, it penetrates without loss into the digestive tract when administered orally. Determination of the highest concentration in serum indicates a 1-2 hour period. 15-20% of the substance binds serum proteins. The degree of bioavailability of the drug reaches 90%.

Dazolik is determined in all tissues of the body, easily penetrates through blood-brain and placental barriers. Metabolized in the kidneys (65%) and the liver (25-30%). The remainder of the drug is excreted unchanged.

Dosing and administration

The method of taking the drug depends on the specific disease that should be treated:

• treatment of trichomonas infection. Assign 0.5 g twice daily for a week. For children, the dosage is calculated from the calculation of 25 mg per kilogram of weight once a day.
• treatment of amoebic infection. Adults appoint 3 tablets once a day for three days. Children are calculated dosage depending on the mass - 40 mg per kilogram of weight. The doctor can change the dose and the frequency of reception at his discretion.
• treatment of Giardiasis. Adults appoint 3 tablets twice a day, treatment lasts no more than 1-2 days.
• preventive measures aimed at preventing anaerobic infection. Before surgery, use 1-2 tablets once, after the operation take 1 tablet twice a day for 5 days.
• treatment of bacterial vaginosis. Depending on the prescription of the doctor, 1 to 3 tablets are taken once a day. The duration of therapy is one week.

Tablets are taken immediately after the meal, with a glass of liquid.

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Use Dazolik during pregnancy

Use of the drug Dazolik during pregnancy has not been studied

Contraindications

Among the contraindications for the use of this drug can include the following:

• an allergic predisposition to some of the components of the drug, or to medications derived from ornidazole;
• organic lesions of the central nervous system;
• children up to the age of three;
• abuse of alcoholic beverages, severe liver damage and blood formation, mental disorders;
• It is not recommended to take the drug to the elderly, as well as to drivers of transport and those whose professional activities are related to the direct management of any mechanisms.

Use of Dazolik during pregnancy is excluded in the first trimester. The need for prescribing in the second and third trimester is determined by the doctor, by commensurating the risk to the growing embryo and the possible benefits for the expectant mother.

In the lactation period, the use of the drug may become possible only if breastfeeding is interrupted. After completing the course of treatment with Dazolik, breastfeeding can be continued, but not earlier than two days after the antibiotic withdrawal.

Side effects Dazolik

Side effects can develop with the use of a large amount of the drug and a long course of treatment.

• Digestive system: dyspeptic phenomena, thirst, taste disorders, tenderness in the stomach, taste of metal in the mouth;
• Nervous system: pain in the head, frustration, trembling in the limbs, impaired motor functions, convulsive conditions;
• The circulatory system: the phenomena of agranulocytosis and leukopenia;
• Immune system: allergic reaction, dermatosis, angioedema.

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Overdose

In cases of drug overdose, the following symptoms may occur:

• drowsy condition;
• pain in the head;
• dyspeptic disorders;
• trembling in the hands;
• weakness in the muscles;
• motor disorders;
• impaired consciousness;
• convulsive conditions;
• violation of enzymatic activity of the liver.

Medical measures in case of an overdose include the cancellation of the drug, gastric lavage, symptomatic therapy. Convulsive conditions can be stopped using diazepam.

Interactions with other drugs

The drug is able to activate the effect of indirect anticoagulants (which may require a lower dosage of the latter), prolongs the period of exposure to virkuronium bromide (muscle relaxant).

The combination of Dazolik and alcohol consumption can provoke the emergence of violent adverse reactions.

Dazolik enhances the effectiveness of the drugs used in anesthesiology.

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Storage conditions

 The drug can be stored in a dark, dry place, the temperature of storage room. It is necessary to ensure inaccessibility of the drug for children.

Shelf life

Dazolik shelf life under storage conditions is up to three years.

Do not use Dazolik after the expiration date.