In the study of pharmacodynamic properties, it was found that cough is a combination drug that is used to specifically eliminate symptoms of cough. Moreover, it can be used also as an auxiliary means by means of which various manifestations of pulmonary diseases are eliminated. This is due to the fact that the drug shows a high tropism in relation to bronchopulmonary tissue.
Particularly active is the salbutamol component, which has a bronchodilator effect. It dilutes sputum and promotes its excretion from the body. Accordingly, the inflammatory process decreases rather quickly, the infection is eliminated. It is also worth noting that it is thanks to salbutamol, which is part of the syrup, that recovery comes much faster. Salbutamol also has mucolytic and expectorant effects. Affects the beta-adrenergic receptors of the bronchi.
Bromhexine is used to dilute sputum. It increases the amount of sputum, so that it is quickly excreted from the body. This may irritate the respiratory tract receptors. Accordingly, cough is worse. But this is not considered a side effect, because it is a natural reflex response of the body to irritation of the respiratory tract receptors. It is worth noting that it is due to the fact that cough increases, sputum is more quickly separated from the walls of the respiratory tract and is more easily excreted from the body.
Also, sputum liquefaction occurs due to the fact that the airway walls are depolarized. Sputum undergoes surface tension, irritates the receptors, which respectively, along the ascending innervation routes transmit the impulse to the cough center of the medulla oblongata. He, in turn, processes the received signal, and sends an impulse to the smooth muscles of the airways. Thanks to this, the contractile activity of the muscles of the bronchopulmonary apparatus is greatly increased, and therefore there is an accelerated excretion of sputum, and another secret.
The third mechanism of action of the drug is that the active ingredient, such as guaifenesin, is included in the formulation. It promotes the activation of the enzymatic activity of those enzymes that make up the mucous membranes. They help dilute those sputum deposits, and other mucus that accumulates on the walls of the respiratory tract. There is also activation of the synthesis of surface immunoglobulin, which provides reliable protection of the body from foreign agents.
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