The effect of the drug begins 30 minutes after ingestion. At the same time the duration of exposure is approximately 6-12 hours, that is, this drug can be attributed to drugs with prolonged action.
We came to the conclusion that the duration of the action is an average of 8 hours, and is determined by the state of the immune system, the severity of the disease, the duration of the disease, and the general level of resistance of the body. The main action is secretory, secretolitic. It is also worth mentioning expectorant effect.
The drug is characterized by absolute bioavailability. The bulk of it accumulates in the lung tissue. Approximately after 30-40 minutes the bioavailability of the drug begins to decrease gradually. In connection with a decrease in bioavailability, there is a gradual excretion of the kidneys.
Ambroxol has the ability to bind to plasma proteins (about 85%, and sometimes even up to 90%). A distinctive feature is the ability to penetrate the walls of blood vessels, accumulate in the cerebrospinal fluid. The drug is withdrawn after approximately 22 hours. Approximately 90% is excreted through the kidneys. Therefore, the drug should be taken with care to patients who suffer from various kidney diseases. Such intensive excretion creates a strong load on the body.
It is worth noting that the drug is better to prescribe for chronic pathologies, since it is excreted from the body for quite a long time, while providing the maximum therapeutic effect.