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Syrup Ambrogen for children cough
It is a syrup that is sold with a measuring cup. The syrup differs transparent color, can be observed slightly yellowish shade. Has a pleasant smell of raspberries, which is very popular with children. It is thanks to these properties of the drug (pleasant aroma and taste), children are happy to drink this syrup. They stabilize the drug, make it stable and effective.
Pharmacodynamics
Pharmacological properties of the drug are known. The difference is that there is no methyl group in the ambroxol, and there is also a hydroxyl group. The main actions of the drug are secretion, secretion and expectorant effects on the respiratory tract.
As the results of preclinical studies show, the essence of the action of ambroxol is that it stimulates serous cells, increasing their activity. Sputum becomes more fluid. This helps cleanse the airways, normalize their patency, eliminate the inflammatory and infectious process. As a result, secretory and ciliary cells are activated. Activated glandular epithelium, which contributes to improving the protective properties of the mucous membranes of the bronchi and lungs. It should be noted that a special role is played by the surfactant, the amount of which sharply increases. In this case, there is a direct effect on the alveoli, alveolar cells and pneumocytes. This increases the amount and viscosity of phlegm, improves mucociliary transport.
Also of some interest is the ability of ambroxol to have an antioxidant effect on the body. Ambroxol can be used together with antibiotics, as a result of which the effects of the drugs are mutually reinforced.
For more information on syrups used for cough for children, see this article .
Pharmacokinetics
The effect of the drug begins 30 minutes after ingestion. At the same time the duration of exposure is approximately 6-12 hours, that is, this drug can be attributed to drugs with prolonged action.
We came to the conclusion that the duration of the action is an average of 8 hours, and is determined by the state of the immune system, the severity of the disease, the duration of the disease, and the general level of resistance of the body. The main action is secretory, secretolitic. It is also worth mentioning expectorant effect.
The drug is characterized by absolute bioavailability. The bulk of it accumulates in the lung tissue. Approximately after 30-40 minutes the bioavailability of the drug begins to decrease gradually. In connection with a decrease in bioavailability, there is a gradual excretion of the kidneys.
Ambroxol has the ability to bind to plasma proteins (about 85%, and sometimes even up to 90%). A distinctive feature is the ability to penetrate the walls of blood vessels, accumulate in the cerebrospinal fluid. The drug is withdrawn after approximately 22 hours. Approximately 90% is excreted through the kidneys. Therefore, the drug should be taken with care to patients who suffer from various kidney diseases. Such intensive excretion creates a strong load on the body.
It is worth noting that the drug is better to prescribe for chronic pathologies, since it is excreted from the body for quite a long time, while providing the maximum therapeutic effect.
Side effects Syrup Ambrobene
Side effects are manifested primarily as allergic reactions. People who are prone to delayed types of allergic reaction develop angioedema, skin rash, itching, burning, dyspnea. With a tendency to allergic reactions of an immediate type, an allergic reaction can develop according to the type of anaphylaxis. Quincke's edema is often observed.
With increasing cough, the rate of excretion of sputum from the body increases, which contributes to a decrease in sputum, inflammatory and infectious processes. Severe skin diseases can develop in patients with Stephen-Johnson syndrome. If the structure and function of the skin changes, you should immediately inform the doctor.
Dosing and administration
Independently treated with this remedy for more than 3 days is contraindicated. It should be taken into account that sputum liquefaction occurs precisely under the condition that there is a sufficient amount of incoherent moisture in the body.
The drug can be taken even by patients under the age of 2 years. Thus, patients under the age of 2 years are recommended to take the drug in half a measuring cup. At the age of 2 to 6 years, the dosage can increase dramatically. So, you can already take one measuring cup to 3-4 times a day. From 6 to 12 years, it is recommended to take a glass 4-5 times a day.
Overdose
Overdose is accompanied by symptoms of intoxication, which are rather poorly expressed. Treatment is to provide intensive care. But such measures are resorted to in case of a sharp, acute overdose, which is accompanied by severe symptoms of poisoning. In general, the treatment is mostly symptomatic.
As special instructions in the instruction it is indicated that the drug can not be taken together with antitussive agents. This is due to the fact that it intensifies cough, while antitussives, on the contrary, reduce it. This can lead to congestion in the bronchopulmonary system. There may also be spasm, cramps, impairment of respiratory function. Therefore, any cough syrup for children should be taken only after a preliminary consultation with a doctor.