Baeta

Byetta is a medical drug that is prescribed to patients with type 2 diabetes. Let's look at the main indications for the use of Byetta, the form of release, contraindications, dosage and rules of use.

Indications Baeta

Indications for use of Byetta - diabetes mellitus type 2. The drug is used as an additional therapy to metaforfin to normalize glycemic control. The active substance of the drug is exenatide. Byetta is produced in the form of a solution, which is intended for subcutaneous administration.

The metabolite is prohibited for use by pregnant women and patients under 18 years of age. Particular attention when using the drug should be paid to the fact that Byetta significantly reduces appetite and body weight. The manifestation of such effects is not necessary to change the dosage of the drug.

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Release form

The release form of Byet is a disposable syringe pen, which is a modern analogue of insulin syringes. The metabolite is released in a volume of 1.2 and 2.4 ml. One package of the drug contains one syringe pen. Treatment begins with the introduction of a dose of Byet of 5 mcg twice a day for a month. This allows the body to adapt to the drug and improve its tolerability. After this, the dosage of Byet can be doubled, and this will not cause side effects.

Byetta is a transparent, colorless solution without a characteristic odor. Per 1 ml of the drug there are 250 mcg of the active substance exenatide. Excipients of the metabolite: acetic acid, matacresol, sodium acetate trihydrate, mannitol and others.

Pharmacodynamics

Pharmacodynamics of Byetta - represents the processes that occur with the drug after use. Byetta is a hypoglycemic drug with the active substance - exenatide (incretin mimetic). Incretins increase insulin secretion and suppress increased secretion of glucagon. Also, incretins slow down the process of gastric emptying after the active substances enter the general bloodstream.

The introduction of the drug leads to a decrease in appetite, suppression of gastric motility and slower emptying (in some patients, constipation occurs). When using Byetta on an empty stomach, the concentration of glucose in the blood decreases, which significantly improves glycemic control in patients suffering from type 2 diabetes.

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Pharmacokinetics

Byetta pharmacokinetics are the absorption, distribution, metabolism and elimination of the drug. Let's take a closer look at all these processes.

• Absorption – after administration, the active substance exenatide is quickly distributed throughout the bloodstream and produces its therapeutic effect.
• Distribution and metabolism – the distribution process of exenatide after administration is 28.3 L. Byetta is metabolized in the pancreas, gastrointestinal tract and bloodstream.
• Excretion – the process of drug excretion takes about 10 hours. Byetta is excreted by the kidneys with urine.

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Dosing and administration

The method of administration and dosage of Byet are prescribed by a doctor. The drug is administered into the forearm, abdomen or thighs. The initial dose of the metabolite is 5 mcg and should be administered twice a day, within an hour before breakfast and dinner. The drug is prohibited to be administered after meals.

If one injection was missed, then further treatment should be continued without changing the dosage. After a month of use, the dose of Byetta is doubled, i.e. 10 mcg twice a day. If Byetta is prescribed with sulfonylurea derivatives, the dosage of the latter is reduced to avoid the occurrence of side effects and overdose symptoms.

Use Baeta during pregnancy

The use of Byet during pregnancy is contraindicated. The use of the drug should also be abandoned during lactation. This is explained by the fact that the active substances of the drug have a negative effect on the development of the fetus. In addition, taking Byet can cause congenital diabetes in the baby, which will make the newborn insulin-dependent.

The use of Baet during pregnancy is prohibited, since during formation and development, the child takes on the functions of producing insulin. That is, the work of the baby's pancreas is able to provide a normal level of glucose and insulin in the mother's blood. That is why, during the period of pregnancy planning, it is very important to undergo diagnostics and get advice on taking medications that could maintain normal blood sugar levels and do not affect the course of pregnancy and the normal development of the child.

Contraindications

Contraindications to the use of Byet are based on individual intolerance to the active substance of the drug. The drug is prohibited for use by people with type 1 diabetes or diabetic ketoacidosis. Patients with severe diseases of the gastrointestinal tract, kidneys and gastroparesis should refrain from using Byet.

Baeta is not recommended for use by patients under 18 years of age, as the efficacy and safety of the drug for children has not been established. The drug is also contraindicated in the presence of hypersensitivity to the components of the metabolite.

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Side effects Baeta

Side effects of Byet occur extremely rarely. And if they do occur, then, as a rule, due to incorrect dosage of the metabolite or use of the drug for which storage conditions or expiration date have been violated. Local side effects manifest themselves as itching, rash and redness at the injection site. Some patients may experience problems with the gastrointestinal tract, nausea, diarrhea, vomiting, loss of appetite.

Very rarely, the use of Byet causes exacerbation of renal failure and an increase in serum creatinine in the blood. When the drug is first administered, slight weakness and tremors are possible, and angioedema and anaphylactic reactions are observed less frequently. If side effects occur, it is recommended to reduce the dose of the drug and seek medical help.

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Overdose

An overdose of Byetta may occur due to the use of a high dose of the drug. The main symptoms of an overdose are nausea, diarrhea, vomiting, flatulence, constipation, taste disturbances and loss of appetite. From the central nervous system, the main symptoms of an overdose are dizziness, headaches and drowsiness.

Most often, overdose symptoms manifest as rash, itching, and swelling at the injection site. Overdose symptoms are moderate in intensity and are treated symptomatically. To eliminate overdose symptoms, it is recommended to review the dosage of the drug and stop using drugs with a similar spectrum of action.

Interactions with other drugs

Interaction of Byetta with other drugs is possible only with a doctor's permission. With special caution, the metabolite is prescribed to patients who take other drugs orally that are absorbed and metabolized in the gastrointestinal tract. Since Byetta can cause delayed gastric emptying. Therefore, any oral medications are recommended to be taken two hours before the administration of Byetta.

If Byetta is prescribed simultaneously with Digoxin, the effectiveness of the latter is reduced. Patients taking Lisinopril and suffering from arterial hypertension should observe the time interval before the introduction of Byetta. Any other interactions may cause adverse reactions. Therefore, before using any drugs with Byetta, it is necessary to consult a doctor.

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Storage conditions

Storage conditions for Baet are specified in the instructions for the drug. The drug should be stored in a dry, dark place at a temperature of 2° to 8°C. If the drug is already in use, it is recommended to store the syringe pen at 25°C and for no more than 30 days. The drug should be kept away from children and should not be frozen.

Please note that the Byetta pen cannot be stored with the needle attached. After each injection, the needle must be removed and a new one must be put on before the next use. Failure to comply with the storage rules will result in the loss of its medicinal properties. Byetta may change its transparent consistency to cloudy, sometimes yellowish flakes appear in the solution. In this case, the drug must be disposed of.

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Special instructions

Byetta is a drug that is a synthetic analogue of human glucagon-like peptide-1, but the drug acts much longer. The drug works like a human hormone, which is a huge plus for people with diabetes. The use of Byetta helps to normalize blood sugar levels, and also normalizes the patient's weight, reduces glycated hemoglobin by 1-1.8%.

Despite the advantages in comparison with other drugs of this type, Byetta has a number of disadvantages. The form of the drug involves only subcutaneous administration, since there is no tablet form of the drug. 30% of patients who take Byetta experience transient side effects. In addition, after the administration of the drug, the concentration of GLP-1 can increase several times, which increases the risk of developing a hypoglycemic state. Byetta is a metabolite that can be used with other drugs to lower blood sugar levels.

Byetta is a synthetic drug that is prescribed to people with type 2 diabetes. The drug is prescribed by the attending physician, so it can only be purchased with a prescription. It is the doctor who selects the dosage of the metabolite and monitors the patient's condition during the use of Byetta.

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Shelf life

The shelf life of Byeta is 24 months from the production date, which is indicated on the drug packaging. After the expiration date, it is strictly forbidden to use the drug, as this may cause uncontrolled side effects. Please note that the shelf life of Byeta also depends on storage conditions, failure to comply with which leads to spoilage of the drug and its disposal.