Bata

Baeta is a medical product that is prescribed to patients with type 2 diabetes. Let's consider the main indications for the use of Baeta, the form of release, contraindications, dosage and rules of use.

Indications Bata

Indications for the use of Baeta - type 2 diabetes mellitus. The drug is used as an additional therapy for metaforphine for the normalization of glycemic control. The active substance of the drug is exenatide. It is produced by Baeta in the form of a solution, which is intended for subcutaneous administration.

Metabolite is prohibited for use by pregnant women and patients who are under 18 years of age. Particular attention when using the drug should be drawn to the fact that Baeta significantly reduces appetite and body weight. The appearance of such effects is not a necessity for changing the dosage of the drug.

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Release form

Form release Baeta - disposable syringe-pen, which is a modern analog of insulin syringes. The metabolite is produced in a volume of 1.2 and 2.4 ml. One syringe-pen in one package. Treatment begins with the introduction of a dose of Baeta in 5 μg twice a day for a month. This allows you to adapt the body to the drug and improve its tolerability. After that, Baeta dosage can be doubled, and this will not cause side effects.

Baeta is a clear, colorless solution with no characteristic odor. For 1 ml of the drug accounted for 250 μg of exenatide active substance. Excipients of the metabolite: acetic acid, matacresol, sodium acetate trihydrate, mannitol and others.

Pharmacodynamics

Pharmacodynamics Bata - represents the processes that occur with the drug after use. Baeta is a hypoglycemic drug with an active substance - exenatide (incretin mimetik). Incretiny strengthen the insulin vector and suppress the increased secretion of glucagon. Also, incretins slow down the process of emptying the stomach after getting active substances into the total blood flow

The introduction of the drug leads to a decrease in appetite, suppression of gastric motility and slowdown of emptying (in some patients constipation occurs). With the use of Baeta on an empty stomach, the blood glucose concentration is reduced, which significantly improves glycemic control in patients with type 2 diabetes mellitus.

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Pharmacokinetics

Pharmacokinetics Baeta is the absorption, distribution, metabolism and excretion of the drug. Let's take a closer look at all these processes.

• Absorption - after administration, the active substance exenatide is quickly distributed through the bloodstream and produces its therapeutic effect.
• Distribution and metabolism - the distribution of exenatide after administration is 28.3 liters. Metabolized Baeta in the pancreas, gastrointestinal tract and blood flow.
• Excretion - the process of excretion of the drug is about 10 hours. It is excreted by Baeta with urine.

[3], [4], [5], [6], [7]

Dosing and administration

The way of application and the dose of Baeta are prescribed by a doctor. The drug is injected into the area of the forearm, abdomen or thighs. The initial dose of the metabolite is 5 μg and it must be administered twice a day, for an hour before breakfast and dinner. The drug is not allowed to enter after meals.

If one injection was omitted, then further treatment should be continued without changing the dosage. After a month of application, the dose of Baeta is doubled, that is, 10 μg twice a day. If Baeta is prescribed with sulfonylurea derivatives, the dosage of the latter is reduced to avoid the occurrence of adverse reactions and symptoms of overdose.

Use Bata during pregnancy

The use of Baeta during pregnancy is contraindicated. From the use of the drug must be abandoned and during lactation. This is due to the fact that the active substances of the drug adversely affect the development of the fetus. In addition, taking Baeta can cause congenital diabetes in the baby, which will make the newborn insulin-dependent.

The use of Baeta during pregnancy is prohibited, as during the formation and development, the child takes on the functions of producing insulin. That is, the work of the pancreas of the baby is able to provide a normal level of glucose and insulin in the mother's blood. That is why, during pregnancy planning it is very important to get diagnostics and get advice on taking medications that could maintain a normal blood sugar level and not affect the course of pregnancy and the normal development of the child.

Contraindications

Contraindications to the use of Baet are based on the individual intolerance of the active substance of the drug. The drug is not allowed to be taken to people with type 1 diabetes or diabetic ketoacidosis. From the use of Baet, patients with severe diseases of the gastrointestinal tract, kidneys and gastroparesis should be discarded.

Baeta is not recommended for use by patients who did not reach the age of 18, because the effectiveness and safety of the drug for children is not established. The drug is contraindicated in the presence of hypersensitivity to the metabolite components.

[8], [9], [10]

Side effects Bata

Side effects of Baet occur extremely rarely. And if they do, then, as a rule, because of an incorrect dosage of the metabolite or the use of the drug in which the storage conditions or shelf life are violated. Local adverse reactions are manifested in the form of itching, rash and redness at the injection site. Some patients may have problems with the gastrointestinal tract, nausea, diarrhea, vomiting, decreased appetite.

Very rarely, the use of Baeta causes an exacerbation of renal failure and an increase in serum creatinine in the blood. With the first administration of the drug, a slight weakness and trembling is possible, rarely angioedema and anaphylactic reactions are observed. If you have any side effects, it is recommended that you lower the dose and seek medical help.

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Overdose

Overdose of Baet may occur due to the use of a high dose of the drug. The main symptoms of an overdose appear in the form of nausea, diarrhea, vomiting, flatulence, constipation, impaired taste sensations and decreased appetite. From the central nervous system, the main symptoms of an overdose are dizziness, headaches and drowsiness.

Most often, the symptoms of overdose manifests itself in the form of rash, itching and swelling at the injection site. The symptomatology of an overdose is moderate in intensity and is treated symptomatically. To get rid of the symptoms of overdose, it is recommended to revise the dosage of the drug and refuse to use medicines with a similar spectrum of action.

Interactions with other drugs

Interaction of Baet with other drugs is possible only by medical permission. With extreme caution, the metabolite is given to patients who take orally other medications that are absorbed and metabolized in the gastrointestinal tract. Because Baeta can cause a delay in emptying the stomach. Therefore, any oral medication should be taken two hours before the introduction of Baet.

If Baeta is prescribed concomitantly with Digoxin, then the effectiveness of the latter decreases. Patients taking lisinopril and suffering from hypertension should observe the time interval before the introduction of Baet. Any other interactions can cause side reactions. Therefore, before using any medications with Baeta, you should consult your doctor.

[12], [13], [14]

Storage conditions

The storage conditions of Baeta are indicated in the product instructions. The drug should be stored in a dry dark place, with a temperature of 2 ° to 8 ° C. If the drug is already in use, then the syringe pen should be stored at 25 ° C and not more than 30 days. The drug should be stored away from children and it is forbidden to freeze.

Pay attention, the syringe-pen Baeta can not be stored with the attached used needle. After each injection, the needle should be removed, and before the next use, wear a new one. Failure to comply with the rules of storage of the drug will lead to the loss of its medicinal properties. Baeta can change its transparent consistency to a cloudy, sometimes yellowish flakes appear in the solution. In this case, the drug must be disposed of.

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Special instructions

Baeta is a drug that is a synthetic analogue of human glucagon-like peptide-1, but the drug lasts much longer. The drug works as a human hormone, which is a huge plus for people with diabetes. The use of Baeta helps normalize blood sugar levels, and also adjusts the weight of the patient, reduces glycated hemoglobin by 1-1.8%.

Despite the advantages in comparison with other drugs of this type, Baeta has a number of disadvantages. The form of release of the drug assumes only a subcutaneous injection, since there is no tablet form of the drug. In 30% of patients who take Baeta, side effects of a transient nature are observed. In addition, after administration of the drug, the concentration of GLP-1 may increase several fold, which increases the risk of developing a hypoglycemic condition. Baeta is a metabolite that can be used with other drugs to lower blood sugar levels.

Baeta is a synthetic drug that is prescribed to people with type 2 diabetes. The drug is prescribed by the attending physician, so you can buy it only by prescription. It is the doctor who selects the dosage of the metabolite and monitors the patient's condition during the application of Baeta.

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Shelf life

Shelf life is 24 months from the date of manufacture, which is indicated on the package of the preparation. After the expiration date, use the drug is strictly prohibited, as this can cause uncontrolled adverse reactions. Please note that the expiry date of Baeta depends on the storage conditions, non-observance of which leads to damage to the medicinal product and its disposal.