Bases

Bazetam - a drug that is prescribed to patients with diseases of the urinary tract and lesions of the prostate. Let's consider the features of the use of this drug, the recommended dosage, indications and contraindications to use, symptoms of overdose and side effects.

Indications Bases

Indications for use Bases are based on the action of the active component of the drug. Bases are prescribed for dysuric symptoms, which are manifested from the lower urinary tract, against a background of benign prostatic hyperplasia.

Bases are prescribed only after a complete examination of the patient in order to exclude diseases with similar symptoms. For this, patients undergo a rectal finger examination of the prostate, that is, the prostate gland and change the level of prostate-specific antigen. Antigen is a tumor marker that helps diagnose cancer, adenoma, hyperplasia and other prostate lesions. This type of diagnosis is carried out throughout the course of treatment.

With special care, the drug is prescribed to patients with severe renal failure, as there is no clinical experience confirming safety of the Basetam. Pay attention, Bazetam is intended for use only in men.

[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]

Release form

Form release Bazetam - capsules. The drug is released in cardboard packs, 10 capsules of the drug in a blister, each pack of three blisters with capsules. One capsule of Bazetam contains: tamsulosin hydrochloride 0.4 mg, ie 0.367 mg of pure tamsulosin. Auxiliary substances of the preparation are methacrylic acid, microcrystalline cellulose, sodium lauryl sulfate and others.

The composition of the drug, in addition to the active and auxiliary substances, includes: iron oxide red (E172), titanium dioxide (E171), indigokarim (E132), iron oxide yellow and black. Capsules Bases have a modified release.

[12], [13]

Pharmacodynamics

Pharmacodynamics Bazetam allows you to learn about the processes that occur with the drug, after getting into the body of the patient. The active substance tamsulosin blocks adrenergic receptors, which are located in the smooth muscles of the prostate, the prostatic part of the urethra and the bladder. Due to this there is a decrease in the tone of the smooth muscles of the prostate and bladder, which greatly facilitates the process of excretion of urine. Also, the action of tamsulosin reduces the painful symptoms and irritability, which are caused by the development of benign prostatic hyperplasia. The positive effect of treatment is noticeable after 14-16 days after the beginning of admission to the Bases.

Due to the fact that the active substance Bazetam affects α1A-adrenergic receptors, it can cause a drop in blood pressure in patients. If the Bases are prescribed to patients with hypertension, special control is required over the patient's condition during the administration of the drug.

[14], [15], [16], [17], [18]

Pharmacokinetics

Pharmacokinetics Bazetam is the reaction of the body to the interaction with the drug. The drug is absorbed in the intestine, so if you take it with food, absorption will decrease significantly. Based on this, it is recommended to take the Bases at the same time, but before meals, as this will provide ideal conditions for effective absorption. Bioavailability is 100%, which indicates a linear pharmacokinetics of the Bases.

The maximum concentration of the drug in the blood plasma is reached in 6-8 hours after administration. The drug is biotransformed in baking, the primary phase of metabolism is insignificant. Part of the drug circulates in the blood in an unchanged form. Tamsulosin and metabolites are excreted unchanged, almost 90% with urine. The half-life of the drug is 10-13 hours.

[19], [20], [21], [22],

Dosing and administration

Dosing and Administration Basetas are prescribed by a doctor and are selected individually for each patient, based on the symptomatology of the disease and the age of the patient. The recommended dose of the drug is one capsule once a day (before breakfast).

The drug must be taken before meals, as Bazetam is absorbed in the gastrointestinal tract, and eating significantly slows the process. The capsule is swallowed whole, without violating its integrity, that is, without chewing, as this can lead to impaired release of tamsulosin, the active substance of the drug. Drink capsules, like any other medicines, only with water.

[28],

Use Bases during pregnancy

Use of Bazetas during pregnancy is strictly prohibited. Since Bazetam is a medicinal product that is prescribed only to men. Bazetam helps in the treatment of diseases of the urinary tract and the prostate.

If during pregnancy a woman has problems with the genitourinary system, it is recommended to seek medical help. But taking Bazetam is forbidden, since the drug does not have a therapeutic effect on the female body. Conversely, it can cause uncontrolled adverse reactions and cause complications of pregnancy.

Contraindications

Contraindications to use Bases are based on individual drug intolerance. Bases are not prescribed in severe form of liver failure and any other diseases of the kidneys and liver. The drug is not recommended for patients with orthostatic hypotension in history.

When taking the Baset, it is contraindicated to drive vehicles and engage in potentially dangerous activities that require concentration of attention and a high rate of psychomotor reactions. Such contraindications are based on adverse reactions that occur in some patients - drowsiness, fainting, dizziness, loss of visual acuity.

[23], [24], [25], [26],

Side effects Bases

Side effects Bases can arise due to non-compliance with instructions and rules for taking the drug. The most common side effects are dizziness, severe headache, fainting. Orthostatic hypertension and tachycardia may occur in patients with cardiovascular diseases. Sometimes side effects Bazetam manifests as inflammation of the nasal mucosa, that is, rhinitis.

If the drug is prescribed to patients with gastrointestinal diseases, constipation, nausea, vomiting and diarrhea are side effects to the Bazetam. Because of the increased dosage of the drug, there may be problems with ejaculation, that is, retrograde ejaculation. Less common side effects Bases cause sensations of chronic fatigue and nervousness.

[27],

Overdose

Overdosing of Bazetam occurs due to the use of a high dose of the drug, exceeding the duration of the course of treatment, the use of a drug that has expired or the storage conditions are violated. The main symptoms of an overdose are high blood pressure and dizziness. In acute overdose, hypotension is possible.

In order to remove symptoms of an overdose of the Baset, it is necessary to prevent the absorption of the drug, that is, to induce vomiting or to perform gastric lavage. Also, the reception of activated carbon and osmotic laxatives will help. In case of acute overdose symptoms, the patient needs medical attention. In this case, the patient is administered vasoconstrictor drugs, controls the state of the kidneys and the work of the cardiovascular system.

[29], [30], [31], [32]

Interactions with other drugs

Interaction of the Bases with other drugs is possible only with the permission of the attending physician. Bazettes are forbidden to take with enalapril, theophylline. If the Bazetam is taken with cimetidine, it will lead to an increase in the active substance, i.e., tamsulosin in the blood plasma, and will cause side reactions and symptoms of an overdose. When taken with furosemide, the concentration of tamsulosin decreases significantly, which leads to a loss of therapeutic effectiveness of the drug.

Bazetam normally interacts with diazepam, propranolol and chloromadinone. If Bazetam is taken with other α-adrenoreceptor antagonists, then this may cause the hypotensive effect.

[33], [34], [35], [36], [37], [38], [39]

Storage conditions

Storage conditions The bases are standard for medications of this form of release. Bases should be stored in a cool dry place, which is inaccessible to children and protected from sunlight. Storage temperature should not exceed 25 ° C.

Failure to comply with the conditions of storage means leads to loss of medicinal properties. And in this case, take the drug is prohibited, as this can lead to the occurrence of adverse reactions and other adverse symptoms.

[40], [41], [42],

Special instructions

Bazetam refers to a pharmacotherapeutic group of drugs that are used to treat benign prostatic hypertrophy and urinary tract damage. Also, the effect of the drug is directed to the treatment of dysuric symptoms, which is caused by hyperplasia of the prostate. The active substance of the drug is tamsulosin.

Shelf life

The shelf life of the Bazetas is three years, that is 36 months from the date of manufacture indicated on the drug package. After the expiration date, the drug is prohibited to use and must be disposed of. This is due to the fact that the active substance of the Bazetas has lost its therapeutic functions, and taking over the overdue Bazetam will lead to the emergence of uncontrolled, unfavorable symptoms that require medical care.

[43], [44]