Bazettam

Bazetam is a drug prescribed to patients with urinary tract diseases and prostate gland lesions. Let's look at the features of this drug, the recommended dosage, indications and contraindications for use, overdose symptoms and side effects.

Indications Bazettam

Indications for use of Bazetam are based on the action of the active component of the drug. Bazetam is prescribed for dysuric symptoms that appear from the lower urinary tract, against the background of benign prostatic hyperplasia.

Bazetam is prescribed only after a full examination of the patient in order to exclude diseases with similar symptoms. For this purpose, patients undergo a digital rectal examination of the prostate, i.e. the prostate gland, and the level of prostate-specific antigen is changed. The antigen is a tumor marker that helps diagnose cancer, adenoma, hyperplasia and other prostate lesions. Such diagnostics are carried out throughout the course of treatment.

The drug is prescribed with special caution to patients with severe renal failure, since there is no clinical experience confirming the safety of Bazetam. Please note that Bazetam is intended for use only in men.

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Release form

Release form of Bazetam - capsules. The drug is released in cardboard packs, 10 capsules of the drug in a blister, each package contains three blisters with capsules. One capsule of Bazetam contains: tamsulosin hydrochloride 0.4 mg, that is 0.367 mg of pure tamsulosin. Excipients of the drug - methacrylic acid, microcrystalline cellulose, sodium lauryl sulfate and others.

In addition to the active and auxiliary substances, the preparation contains: iron oxide red (E172), titanium dioxide (E171), indigocarim (E132), iron oxide yellow and black. Bazetam capsules have a modified release.

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Pharmacodynamics

Pharmacodynamics of Bazetam allows you to learn about the processes that occur with the drug after it enters the patient's body. The active substance tamsulosin blocks adrenergic receptors, which are located in the smooth muscles of the prostate, prostatic part of the urethra and bladder. Due to this, the tone of the smooth muscles of the prostate and bladder decreases, which significantly facilitates the process of urine excretion. Also, the action of tamsulosin reduces painful symptoms and irritability, which are caused by the development of benign prostatic hyperplasia. The positive effect of treatment is noticeable 14-16 days after the start of taking Bazetam.

Due to the fact that the active substance Bazetam affects α1A-adrenoreceptors, this can cause a decrease in blood pressure in patients. If Bazetam is prescribed to patients with arterial hypertension, then special monitoring of the patient's condition is required during the administration of the drug.

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Pharmacokinetics

Pharmacokinetics of Bazetam is the body's reaction to interaction with the drug. The drug is absorbed in the intestine, so if you take it during meals, absorption will be significantly reduced. Based on this, it is recommended to take Bazetam at the same time, but before meals, as this will provide ideal conditions for effective absorption. Bioavailability is 100%, which indicates the linear pharmacokinetics of Bazetam.

The maximum concentration of the drug in the blood plasma is achieved 6-8 hours after administration. The drug is biotransformed in the liver, the primary phase of metabolism is insignificant. Part of the drug circulates in the blood unchanged. Tamsulosin and metabolites are excreted unchanged, almost 90% with urine. The half-life of the drug is 10-13 hours.

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Dosing and administration

The method of administration and dosage of Bazetam are prescribed by a doctor and selected individually for each patient, based on the symptoms of the disease and the age of the patient. The recommended dose of the drug is one capsule once a day (before breakfast).

The drug should be taken before meals, since Bazetam is absorbed in the gastrointestinal tract, and food intake will significantly slow down this process. The capsule is swallowed whole, without breaking its integrity, that is, without chewing, as this can lead to disruptions in the release of tamsulosin, the active substance of the drug. Capsules, like any other medicine, should be washed down with water only.

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Use Bazettam during pregnancy

The use of Bazetam during pregnancy is strictly prohibited. Since Bazetam is a drug that is prescribed only to men. Bazetam helps in the treatment of diseases of the urinary tract and prostate gland.

If a woman has problems with the genitourinary system during pregnancy, it is recommended to seek medical help. But taking Bazetam is prohibited, since the drug does not have a therapeutic effect on the female body. On the contrary, it can cause uncontrolled side effects and complications during pregnancy.

Contraindications

Contraindications to the use of Bazetam are based on individual intolerance to the drug. Bazetam is not prescribed for severe liver failure and any other kidney and liver diseases. The drug is not recommended for patients with a history of orthostatic hypotension.

When taking Bazetam, it is contraindicated to drive vehicles and engage in potentially dangerous activities that require concentration and high speed of psychomotor reactions. Such contraindications are based on adverse reactions that occur in some patients - drowsiness, fainting, dizziness, loss of visual acuity.

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Side effects Bazettam

Side effects of Bazetam may occur due to non-compliance with the instructions and rules for taking the drug. The most common side effects are dizziness, severe headache, fainting. Patients with cardiovascular diseases may experience orthostatic hypertension and tachycardia. Sometimes side effects of Bazetam manifest as inflammation of the nasal mucosa, i.e. rhinitis.

If the drug is prescribed to patients with gastrointestinal diseases, then constipation, nausea, vomiting and diarrhea are side effects of Bazetam. Due to the increased dosage of the drug, there may be problems with ejaculation, that is, retrograde ejaculation. Less often, side effects of Bazetam cause feelings of chronic fatigue and nervousness.

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Overdose

An overdose of Bazetam occurs due to the use of a high dose of the drug, exceeding the duration of the course of treatment, taking a drug that has expired or storage conditions have been violated. The main symptoms of an overdose are high blood pressure and dizziness. In case of acute overdose, arterial hypotension is possible.

In order to remove the symptoms of an overdose of Bazetam, it is necessary to prevent the absorption of the drug, that is, to induce vomiting or wash out the stomach. Also, taking activated carbon and osmotic laxatives will help. In case of acute symptoms of an overdose, the patient needs medical care. In this case, the patient is administered vasoconstrictor drugs, the condition of the kidneys and the work of the cardiovascular system are monitored.

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Interactions with other drugs

Interaction of Bazetam with other drugs is possible only with the permission of the attending physician. Bazetam is prohibited to take with enalapril, theophylline. If Bazetam is taken with cimetidine, this will lead to an increase in the active substance, that is, tamsulosin in the blood plasma and will cause side effects and overdose symptoms. When taken with furosemide, the concentration of tamsulosin is significantly reduced, which leads to a loss of the therapeutic effectiveness of the drug.

Bazetam interacts normally with diazepam, propranolol and chlormadinone. If Bazetam is taken with other α-adrenergic receptor antagonists, this may cause a hypotensive effect.

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Storage conditions

Storage conditions for Bazetam are standard for medicinal products of this form of release. Bazetam should be stored in a cool, dry place, inaccessible to children and protected from sunlight. The storage temperature of the drug should not exceed 25 °C.

Failure to comply with the storage conditions of the product leads to the loss of its medicinal properties. And in this case, taking the drug is prohibited, as this can lead to the appearance of side effects and other unfavorable symptoms.

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Special instructions

Bazetam belongs to a pharmacotherapeutic group of drugs that are used to treat benign prostatic hypertrophy and urinary tract lesions. Also, the drug is aimed at treating dysuric symptoms caused by prostatic hyperplasia. The active substance of the drug is tamsulosin.

Shelf life

The shelf life of Bazetam is three years, i.e. 36 months from the production date indicated on the drug packaging. After the expiration date, the drug is prohibited for use and must be disposed of. This is due to the fact that the active substance Bazetam has lost its therapeutic functions, and taking expired Bazetam will lead to the appearance of uncontrolled, adverse symptoms that require medical attention.

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