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Vabadine 10 mg
Last reviewed: 23.04.2024
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Vabadin® 10 mg belongs to the pharmacological group of antisclerotic drugs and is a lipid-lowering drug that affects the synthesis of lipoproteins (complex proteins that carry cholesterol) and regulates the level of cholesterol, triglycerides (fatty esters) and phospholipids (fat-like substances) in blood plasma.
Indications Vabadine 10 mg
This drug is used in the complex therapy of diseases of the cardiovascular system, which are caused or accompanied by a violation of lipid (fat) metabolism in the body: high cholesterol in the blood (hypercholesterolemia) of all types, as well as pathologically high levels of lipids or lipoproteins (dyslipidemia).
In addition, Vabadin® 10 mg (synonyms - simvastatin, vasilip, zocor, simvacard, simvor, simgal) is prescribed to prevent the development of cardiovascular pathologies associated with atherosclerosis.
Release form
Form of production Vabadin® 10 mg - coated tablets in a contoured package (14 pieces each), in a cardboard bundle - 2 contour packs. One tablet of Vabadin® 10 mg contains 10 mg of simvastatin, as well as excipients, including lactose monohydrate.
Pharmacodynamics
The active substance of the drug Vabadin® 10 mg - statin simvastin (simvastatin) - is metabolized in the body with the formation of free hydroxycarboxylic acids, which inhibit the production of the enzyme (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase), the necessary liver for cholesterol production, and thereby reducing the concentration of total cholesterol in the blood. The concentration of cholesterol in the blood largely depends on the rate of its capture by special cells (atherogenic low density lipoprotein or LDL and very low density - VLDL), which carry cholesterol and triglycerides to the cells of all tissues, including the walls of blood vessels.
Vabadin® 10 mg also stimulates the formation of "bad" cholesterol receptors of high-density lipoproteins (HDL), which can remove cholesterol from cells and transfer it to the liver for decomposition by oxidation into bile acids. As a result of these biochemical processes, the deposition of cholesterol on the walls of blood vessels decreases, that is, the risk of developing atherosclerosis, and in ischemic heart disease (CHD) - the threat of myocardial infarction.
Pharmacokinetics
After taking the drug inside, it is well absorbed in the gastrointestinal tract, up to 95% of the active substance binds to blood plasma proteins. Pharmacologically active metabolite is formed in the liver, and its maximum concentration in blood plasma is achieved 1-2 hours after taking the drug.
Most of the drug Vabadin® 10 mg is excreted unchanged through the intestine, the rest - with urine. The average time for complete removal of the drug from the body is 96 hours.
Dosing and administration
Dosage and duration of treatment are determined by the doctor. The maximum daily dose of Vabadin is 80 mg, taken once a day - in the evening. Tablets are taken whole by mouth, washed down with 200 ml of water.
With a high degree of risk of cardiovascular disease - for the purpose of prevention - 20-40 mg of the drug is prescribed. If necessary, the dose may be gradually increased (the interval between dose increases is not less than four weeks).
If at the same time treatment is carried out with means to increase the secretion of bile acids, then Vabadine should be taken 4 hours after or 2 hours before taking these drugs.
Use of the maximum daily dose of Vabadin® 10 mg requires regular monitoring of lipid levels in the blood, liver function, and the general well-being of the patient.
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Use Vabadine 10 mg during pregnancy
Use of Vabadin® 10 mg during pregnancy and during lactation is contraindicated. When taking the drug, women of childbearing age are recommended to use reliable contraceptives. The drug is not prescribed for children and adolescents under 18 years of age.
Contraindications
Among the contraindications to the use of Vabadin® 10 mg are: individual hypersensitivity to the components of the drug; exacerbation of liver diseases; lactase deficiency (impaired digestion of milk protein).
Side effects Vabadine 10 mg
The use of this medication can cause the following side effects: headache and dizziness; temperature increase; nausea, vomiting; skin rash, itching, hives, hair loss; suffocation, hyperemia of the face and upper part of the trunk; pain in the upper abdomen, in the muscles and joints; stool, flatulence; paresthesia and muscle spasms; pancreatitis, hepatitis, jaundice.
Overdose
Overdosing of the drug leads to a more pronounced manifestation of side effects.
Methods for eliminating the effects of drug overdose are gastric lavage, intake of enterosorbents, if necessary, symptomatic treatment.
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Interactions with other drugs
Contraindicated to combine the use of Vabadin® 10 mg with drugs that suppress the enzyme CYP3A4 - erythromycin, nefazodone, itraconazole and ketoconazole.
Do not prescribe Vabadin® 10 mg concomitantly with a drug of the same pharmacological group - giphyprosyl as a lipid-lowering drug.
Simultaneous administration of such drugs as cyclosporine, danazol and niacin requires a mandatory adjustment of the dosage of Vabadin® 10 mg to a maximum daily dose not exceeding 10 mg. Special note: during treatment with Vabadin® 10 mg, the use of grapefruit juice is contraindicated, since this juice leads to an uncontrolled increase in the effect of the drug.
Storage conditions
The drug should be stored in a dry place, away from direct sunlight, at temperatures up to + 25 ° C.
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Special instructions
The elderly patient, as well as patients with kidney pathologies, a deficiency of thyroid hormones (hypothyroidism), alcohol dependence and diseases of the muscular system Vabadin® 10 mg is administered with caution. This applies to those whose work is related to the management of vehicles and machinery.
Shelf life
Shelf life of the drug is 3 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Vabadine 10 mg" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.