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Vabadin 20 mg
Last reviewed: 03.07.2025
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Vabadin 20 mg is a cardiovascular anti-sclerotic drug, analogs are simvastatin, atherostat.
Indications Vabadin 20 mg
The drug Vabadin 20 mg can be prescribed for the treatment of patients with signs of elevated cholesterol in the blood, in particular, homozygous or familial type.
Other indications for use of the drug:
- mixed form of dyslipidemia;
- prevention of atherosclerotic cardiovascular changes;
- metabolic disorders, diabetes mellitus with cholesterol imbalance.
Release form
The drug Vabadin 20 mg is produced in tablet form. The cardboard package contains two blister strips with 14 film-coated tablets in each strip.
One tablet form contains the active ingredient simvastatin in the amount of 20 mg, as well as additional substances in the form of lactose monohydrate.
Pharmacodynamics
Vabadin 20 mg is a hypocholesterolemic drug with the active substance simvastatin. The drug is administered orally, simvastatin is metabolized in the liver, where a pharmacologically active form is formed. This drug is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, inhibits the transition of coenzymes into mevalonic acids, reducing the natural synthesis of cholesterol.
Vabadin 20 mg reduces the amount of cholesterol in the body, and it does not matter how much was present in the blood initially.
In addition to inhibiting cholesterol synthesis, the drug can promote activation of low-density lipoprotein receptors. The amount of blood plasma proteins and triglyceride levels decrease, and the concentration of lipoproteins increases.
Pharmacokinetics
After oral administration, the drug is perfectly absorbed in the digestive system. The metabolism process occurs in the liver: a pharmacologically active metabolite is formed. The maximum threshold of the metabolite content in the blood serum is observed 1.5-2 hours after the drug enters the stomach. The presence of food residues in the stomach, as a rule, does not affect the degree of absorption and bioavailability of the active substance. The drug binds well to serum proteins (95%). The drug is excreted through the intestines and partly through the kidneys.
Vabadin 20 mg does not accumulate in the body and should be eliminated within approximately 96 hours.
Dosing and administration
The drug Vabadin 20 mg is used for oral administration, the coated tablet should be swallowed without chewing or breaking, washed down with water. The daily dose is usually prescribed once a day. For greater effectiveness of treatment, the tablet should be taken closer to the evening or in the afternoon.
When using drugs that enhance the secretory activity of the gallbladder in combination, it is necessary to maintain a pause of at least 4 hours between taking the two drugs.
The duration of treatment and dosage are determined by the doctor individually. The standard dosage is 5-80 mg once a day.
Patients with elevated cholesterol levels should follow a special diet during treatment, limiting the consumption of foods with a high content of animal fats. Treatment of such patients usually begins with a dosage of 10 mg.
For patients with hereditary high cholesterol, the initial dosage may be increased to 40 mg.
When prescribing any treatment regimen, the daily amount of the drug should not exceed 80 mg.
Patients at risk of cardiac diseases may be prescribed 20-40 mg of the drug per day for preventive purposes. The dosage is gradually increased, depending on the doctor's recommendation. The dosage is increased slowly, over at least four weeks.
If the drug Vabadin 20 mg is used in the maximum dosage (80 mg), treatment should be carried out under the control of blood tests, liver function and the general condition of the patient.
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Use Vabadin 20 mg during pregnancy
Vabadin 20 mg is contraindicated for use during pregnancy. Moreover, before starting treatment with this drug, women of reproductive age must confirm the absence of pregnancy, and during the period of use of the drug, use acceptable methods of contraception. If planning a pregnancy, the drug should be discontinued at least 30 days before the planned conception.
The possibility of using the drug during breastfeeding is usually discussed with a doctor. Most often, the lactation period is interrupted.
Contraindications
The following series of contraindications for taking the drug Vabadin 20 mg can be identified:
- hypersensitivity to individual components of the drug;
- signs of galactose intolerance, lactose deficiency, glucose-galactose malabsorption;
- severe liver pathologies;
- pregnancy and lactation period, children under 18 years of age.
It is not recommended to use the drug in case of serious kidney pathologies, decreased thyroid function, alcohol dependence, in old and senile age.
Caution is required when prescribing the drug to people whose profession involves operating various complex mechanisms or driving a car.
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Side effects Vabadin 20 mg
Sometimes the use of the drug Vabadin 20 mg can provoke the appearance of some side effects:
- digestive disorders, bouts of nausea, bloating, dysfunction of the liver and pancreas;
- migraine, numbness in the extremities, polyneuropathy;
- muscle pain and cramps, arthrosis, joint pain;
- signs of anemia, increased ESR, thrombocytopenia and eosinophilia;
- increased activity of liver transaminases, alkaline phosphatases and creatine phosphokinase;
- allergic reaction in the form of dermatitis, urticaria, conjunctivitis, vasculitis.
Among the rarer side effects are the development of baldness, hyperthermia, and redness of the skin.
Overdose
The use of Vabadin 20 mg in quantities exceeding 80 mg may be accompanied by increased side effects.
Overdose of the drug requires gastric lavage and the use of activated carbon suspension. In some cases, symptomatic treatment is possible.
Signs of overdose may not pose a threat to the patient's life.
Interactions with other drugs
The combined use of the drug, nicotinic acid and fibrates contributes to an increased risk of developing various myopathies and rhabdomyolysis.
Contraindications to co-administration may include taking CYP3A4 inhibitors, in particular itraconazole, nefazodone, erythromycin and ketoconazole.
The use of this medication and gemfibrozil is not recommended. If such a combination is essential, the maximum dosage of Vabadin should not exceed 10 mg. The same should be done when using cyclosporines, danazol and niacin together.
When combined with amiodarone or veropamil, the maximum dosage of Vabadin should not exceed 20 mg/day.
When combined with diltiazem, the dosage of Vabadin should not exceed 40 mg/day.
During the course of treatment, you cannot eat grapefruit or drink grapefruit juice.
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Storage conditions
The medicinal product Vabadin 20 mg is stored in an inaccessible place, closed from direct exposure to ultraviolet rays. The storage temperature is 15-24° C
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Special instructions
Before using the medicine Vabadin® 20 mg, you must consult a doctor. Using the drug on your own is unacceptable.
Shelf life
The shelf life of the drug Vabadin 20 mg is up to three years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Vabadin 20 mg" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.