Anemia in adenoids: treatment regimen

Adenoids bring a lot of worry to sick children and their parents. The disease, no doubt, must be treated. If you do not take any measures, it can go into a chronic form, can cause numerous complications. There are many ways to treat adenoids, relieve symptoms, alleviate the condition of the body. But the drawback of most of the funds is that most of them are conducted exclusively in the doctor's office or in the hospital. But thanks to the efforts of pharmacists, today there is the opportunity to apply a new tool for treating adenoids at home. The drug avamis in adenoids in children today is quite effective and in demand.

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Indications of the avadis for adenoids

Indications for the use of Awamis are the first signs of adenoiditis. It is used if the child has difficulty breathing, if there is constant snoring, especially at night. If the child constantly breathes through the mouth, even during the day. Indication for use is a permanent, persistent runny nose, which can not be treated by any other means. Prolonged allergic reactions, persistent rhinitis, forced to turn to Awamis.

Adenoiditis can be suspected in the child and independently. It is indicated by sufficiently bright and specific signs. The doctor usually diagnoses quickly enough. It does not require additional differential diagnosis, a general examination and the results of laboratory and instrumental research are sufficient.     

Avamis is used not only for the treatment of adenoids, it can also be used to treat allergic and vasomotor rhinitis, sinusitis, and other purulent and inflammatory diseases of the nasopharynx, pharynx. It can be used in the treatment of otitis, tubootids, which are usually a complication of respiratory diseases.

[3], [4], [5]

Release form

This drug has only one form of release - nasal spray. Produced in the form of a bottle of unusual design, which contains a dispenser and a nebulizer. Each dose has the same volume and concentration. In the center of the bottle there is a transparent window, which makes it possible to control the amount, the remainder.

It is a hormonal drug that has a local effect, refers to the glucocorticoid series. Has anti-allergic and anti-inflammatory effect. The composition also additionally includes cellulose, polysorbate, purified water and dextrose.

The drug is issued under the name Avamis. This tool is English-made. There are also its analogues, which do not differ anything except the country of origin. Belgium produces Nazonex, in Poland - Fliksonase. These drugs are completely identical in composition and contain the same dosage. They are applied in the same way as Avamis, in the same concentration. Can differ in cost.

Pharmacodynamics

The basis of the action of Avamis is the action of hormonal drugs. They exert an exclusively local effect on the mucous membrane of the nasopharynx, as well as directly on the adenoids. Systemic drugs do not have. In the blood they penetrate in minimal amounts, and immediately undergo metabolism in the liver. The blood does not accumulate in the blood plasma. This explains their relative safety. The drug can be administered even to children.

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Pharmacokinetics

The drug is characterized by the ability to partially adsorb cells of the nasopharynx. It is characterized by high affinity and biological activity. Due to this property, like affinity, the drug has only a local effect on the body. The absence of a systemic action determines its relative safety. It does not affect other internal organs and systems.

Affinity implies affinity with the receptors of glucocorticoid hormones and ensures high bioavailability of the drug in the area of nebulization, that is, in the nasopharynx. The active substance selectively binds only to the active sites of the necessary analyzers, which significantly narrows the spectrum of its action. Due to this, unwanted reactions and side effects are blocked. Prevent unwanted allergic reactions, intolerance. A high degree of affinity also implies a strong and long-term drug-receptor bond, so that the period of action of the drug is significantly increased.

This increases the selectivity of the drug and reduces the negative consequences of taking hormonal drugs. Due to the fact that the nasal cavity is irrigated and not buried, a large surface area is covered by the action of drugs. Since the drug binds to sensitive receptors, this eliminates the possibility of attaching foreign agents to them. Thus, the risk of allergic reactions is significantly reduced. Because of this, the drug can be administered even to children.

In severe renal failure, the drug is contraindicated. This is due to the fact that in small amounts it penetrates into the blood, then enters the liver and there is its processing along an extensive path of metabolism. In this regard, the load on the liver increases dramatically.

Dosing and administration

Children from 2 to 12 years of age, the drug is prescribed at a dose of no more than once a day. After 12 years, as well as adults, 2 doses are recommended. The application is daily, the duration of treatment depends on many factors and is determined by the attending physician. The duration of treatment depends on the results of laboratory and instrumental analyzes.

Use of the avadis for adenoids during pregnancy

Avamis is a hormonal drug. But it has a peculiarity - it is quickly removed from the body, does not stay in the tissues and has a high selectivity of action, binding only to the receptors of the glucocorticoid hormones of the nasopharynx. Thus, the systemic effect of the drug is excluded. Drugs with a local effect can be considered relatively safe. In addition, it does not cause addiction and drowsiness. But the advisability of its use during pregnancy and lactation is still a contentious issue.

High selectivity and local action does not preclude the drug from entering the minimal doses into the blood. The drug is also able to penetrate the transplacental barrier in minimal, practically harmless concentrations. However, pregnant women already have a high hormonal imbalance, and the fetus is extremely sensitive to any concentrations of foreign substances.

Most experts are inclined to the opinion that it is better not to use the drug without pregnancy. Awamis is resorted to when other methods of therapy are ineffective.

Contraindications

The drug is contraindicated in cases of severe allergies and individual intolerance to its components. With bronchial asthma, it can worsen the condition, cause choking. Anaphylactic shock may develop, allergic reactions of a local nature, angioedema, hives. This is mainly observed with an overdose.

The drug is not recommended for children younger than 2 years of age. Also, the drug is contraindicated in people who suffer from liver failure. A small amount of the drug enters the systemic circulation and enters the bloodstream. In this case, a small amount of the drug enters the liver and increases the load on it.

The drug is not recommended for use with a tendency to nosebleeds and damage to the nasal mucosa. Also, you should refrain from using the drug in the postoperative period.

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Side effects of the avadis for adenoids

With proper and strict adherence to the regimen of treatment and dosage, side effects are almost not observed. In rare cases, dryness and burning of the nasal tracts, swelling in the throat can be observed. With prolonged admission, there may be allergic reactions to the background of excessive dryness of the mucosa. Coughing and sneezing may also occur. If a person has a tendency to bleed, nasal bleeding may occur. In case of an overdose or a violation of the treatment regimen, nasal erosion and ulcers may occur.

In people with bronchial asthma, allergies may develop swelling, anaphylactic shock. All this is usually accompanied by a headache.

Overdose

Overdosing can trigger simultaneous reception of Avamis with other hormonal medications. Do not use the drug in the treatment of glucocorticosteroids. Sometimes, with dosage, irritation, disturbance, and adrenal function may change. This can cause significant growth retardation. Therefore, with prolonged treatment with Avamis, it is necessary to regularly measure the growth of the child.

Interactions with other drugs

The drug can not be used in conjunction with other hormonal drugs, because there is an overdose. It is not compatible with such drugs as ritonavir and ketoconazole. With the joint administration of these drugs, an overdose is also observed, which manifests itself in the form of rapid heartbeat, weakness, and pressure drop.

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Storage conditions

The drug is stored in a dry, protected from light place. Store in original packaging.

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Shelf life

In the packed form the preparation can be stored for 2 years from the moment of manufacture. In unpacked form the drug is stored for 3-4 months.

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Reviews

Reviews about the drug is very controversial. Some argue that the drug is effective in the common cold, colds. It is enough 1-2 inhalations a day and the child feels much better. Some argue that the drug does not have the desired effect, in addition, it develops habituation.

Many parents write that before the use of the drug their child was ill for a long time, worried adenoids, frequent colds. There were numerous adenoids. For those children who did not get adenoids, the drug allows you to monitor the condition, reduce the symptoms of the disease. Those children whose adenoids are removed with the help of Awamis easily tolerate the postoperative period. Significantly reduces the risk of complications, well-being is much better.

Still, most parents tend to believe that Awamis is an effective remedy. There are reviews, according to which, Awamis helps even with adenoids of the third degree. Some use the drug for prevention, it helps to prevent a runny nose, inflammation of the adenoids. The baby breathes quietly, through the nose. At night he does not snore. On examination, doctors detect a decrease in adenoids in size. Also, the drug promotes the removal of edema, resulting in decreased adenoid tissue and reduced inflammation. Duration of admission in most patients is a month. Many complain about the high cost of the drug, but they agree that the price corresponds to the quality.

If you analyze the reviews of professionals who appoint Avamis to their patients, it is worth noting: they consider it a successful drug of choice, which is effective and safe in the face of all precautions. The drug is hormonal, but it has a gentle effect. The effect of the drug is local.

Although it should be noted that most doctors are still experimenting with this drug, since an approved evidence base and full-fledged randomized trials have not yet been conducted. There is also no standardized method for taking the drug, which would indicate which way and in what dosage the drug should be used.

Awamis in adenoids in children is prescribed for the purpose of relieving inflammation. Direct action on reducing adenoids, it does not provide, only indirectly affects by eliminating edema and inflammation. And this makes it possible to control the condition, prevent inflammation and eliminate symptoms. In many children, adenoids are restored to normal size.