Hofitol

Hofitol is a phytopreparation, has a diuretic and choleretic effect. Among its effects is also a decrease in azotemia.

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Indications of the hofitol

The drug Hofitol is used in the complex treatment of such diseases:

• Atherosclerosis;
• Chronic form of hepatitis (including alcoholic hepatopathy);
• Chronic galloping cholecystitis;
• Non-alcoholic fatty liver disease (fatty hepatosis);
• Obesity;
• Dyskinesia of bile ducts in hypokinetic form;
• Intoxications having a chronic form (this includes poisoning with alkaloids, various hepatotoxic materials, salts from heavy metals, and also nitro compounds);
• Cirrhosis of the liver;
• Acetonemia;
• Oliguria, which occurs with a syndrome of heart failure or cirrhosis;
• Renal failure in chronic form;
• Chronic form of jade.

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Release form

1. Tablets, dosage of one 200 mg. In one package 1 tube with tablets in the amount of 60/180 pieces. The tablets have a lenticular shape, a brown shell, in the place of the fracture, one can see a brown mass.
2. The solution used inside - 1 bottle (dark glass) contains 200 ml of solution (in 1 ml - 200 mg).
3. A solution used parenterally - 1 box contains 5 ampoules of the drug, in 1 ampoule 5 ml of the solution (in 1 ml - 200 mg).

Pharmacodynamics

Hofitol is of vegetable origin and has a hepatoprotective, choleretic, and diuretic effect on the body. In addition, the drug reduces the amount of urea in the blood. In the medicine there is artichoke extract that contains carotene, as well as ascorbic acid along with inulin, and in addition vitamins of groups B1 and B2. All these substances stabilize metabolism. Hofitol also increases the production of coenzymes by hepatocytes and, at the same time, affects the metabolism of substances such as cholesterol, lipids, and ketone bodies. During the treatment with antibiotics, the drug detoxifies the renal or hepatic parenchyma. The drug removes various toxic substances from the body.

Pharmacokinetics

Artichoke extract contains a whole complex of bioactive components - such as polyphenolic elements (it's luteolin and cynarine, and various acids (among them caffeine, and ferulic and chlorogenic)), inulin, bioflavonoids, various vitamins with minerals, and trace elements and sesquiterpene lactones. Thus, the effect of the drug is caused by the combined effect of all these substances. That is why it is impossible to conduct kinetic studies of the drug - it is impossible to trace all elements with the help of bioassays or markers. Because of this, it is also impossible to identify all the metabolites of the drug.

Dosing and administration

Hofitol in tablets: 1-2 tablets. Three times a day. Adults, and also children 12+ years old. Children aged 6-12 years - 1 table. Three times a day. Therapeutic course lasts 2-3 weeks. New courses can be prescribed only on the advice of a doctor.

Hofitol in a solution of internal reception: appointed in a dosage of 2.5-3 ml three times a day. Before eating. The treatment course usually has a duration of no more than 2-3 weeks. Children under 15 years - a quarter or half of the above adult dose.

Hofitol in ampoules (intravenous and -musical injections): adults and children 15+ years - 1-2 ampoules a day (dose increases if necessary) for 8-15 days. After this period, you can switch to the use of a solution or tablets. Children under the age of 15 can enter a quarter or half of the adult dose.

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Use of the hofitol during pregnancy

When pregnant, take the drug Hofitol can only be prescribed by a doctor. Sometimes this drug is used in the complex treatment of hypertension (pre-eclampsia), as well as in the early stages of pregnancy as a prophylactic measure for the occurrence of late gestosis (if there are risk factors that can trigger the development of this disease).

Contraindications

The drug is contraindicated in cases when it is observed:

• Blockage of the biliary tract;
• Disturbances in the liver or kidneys, as well as the urine and bile ducts (in acute form);
• Increased individual sensitivity to the elements of the drug;
• Liver insufficiency in severe form;
• Cholelithiasis.

Side effects of the hofitol

Among the side effects of medication: if taken for a long period in large doses, diarrhea may occur. It is possible to have an allergy (in the form of urticaria) on the ether of parahydroxybenzoate, which is contained in the solution for ingestion and tablets.

Overdose

Overdose causes an increase in the manifestations of the above side effects.

Storage conditions

Keep the medicine at a temperature of no more than 25 ° C.

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Shelf life

Hofitol in tablet form is usable for 3 years. In the form of a solution for ingestion - is valid for 4 years. The injection solution has a 2-year shelf life.