Barbovale

Drug affecting the central nervous system. We will acquaint ourselves with his instructions, indications for use, dosage and side effects. Barboval is included in the pharmacological category of sedative and hypnotic medicines. Has a combined composition that provides a sedative, hypotensive and antispasmodic effect. Relaxes smooth muscles and diminishes flatulence. It contains phenobarbital, which has a vasodilating and sedative effect. The spasmolytic effect is caused by the action of ethyl ester of α-bromoisovaleric acid.

Indications of the barbovale

Barboval is prescribed for the treatment of central nervous system disorders. This is due to its calming, vasodilating and antispasmodic effect.

Indications for use:

• Insomnia
• Neuroses
• Hysteria
• Irritability
• Sinus tachycardia
• Arterial hypertension of the first stage
• Attacks of angina pectoris (mild degree)
• Spasms of the intestines and stomach
• Flatulence

Medication helps to slow the peristalsis of the intestines and stomach, reduces flatulence and has a relaxing effect on the muscular system.

Release form

The sedative is released in the form of drops in bottles of 25 ml, 30 ml and 50 ml and in the form of hard gelatin capsules. These release forms allow you to calculate the amount of medicine needed for treatment.

• 1 ml of Barboval contains: 17 mg of phenobarbital, 80 mg of liquid validol, 18 mg of ethyl ester of a-bromoisovaleric acid. Excipients: sodium sodium trihydrate, rectified ethyl alcohol and purified water.
• 1 capsule contains: 10 mg of ethyl ester of α-bromoisovaleric acid, 9.8 mg of phenobarbital, 46 mg of a solution of menthol in the menthyl ester of isovaleric acid. Auxiliary components: lactose, castor oil, calcium stearate, microcrystalline cellulose, silicon dioxide colloidal and crospovidone.

Pharmacodynamics

The therapeutic effect of the drug is due to its combined composition. Pharmacodynamics is represented by such substances:

• Phenobarbital - enhances the sedative effect of other components, reduces the level of excitation of the central nervous system and restores sleep. Reduces blood pressure, pathological effects on vasomotor centers, peripheral and coronary vessels. Warns and eliminates vascular spasms.
• Ethyl ester of a-bromoisovaleric acid - has an antispasmodic, soothing and reflex action. These effects are due to irritation of the receptors of the oral cavity and nasopharynx, a decrease in the reflex excitability of the central nervous system and increased inhibition of processes in the subcortical structures and neurons of the brain. Reduces the activity of the central vasomotor centers, has an antispasmodic effect on smooth muscle.
• Levomenthol solution in mentilizovalerate - has a mild vasodilating and sedative effect. This effect is caused by irritation of sensitive nerve endings. The substance slows the peristalsis of the gastrointestinal tract.

Pharmacokinetics

After ingestion, the drug spreads through the body, providing therapeutic effects. Pharmacokinetics is based on the mechanism of action of its active components.

Barboval has a long soft effect. Active substances are quickly absorbed in the stomach, binding to blood proteins 40-60%. The half-life is 2-6 days. Metabolism occurs in the liver, about 30% of the drug is excreted unchanged in the urine. With repeated use of the medicine cumulates and is withdrawn from the body very slowly.

Dosing and administration

As a rule, Barboval appoint 10-15 drops or 1-2 capsules at a time. The medication is taken 2-3 times a day, depending on the severity of the pathological symptoms requiring treatment. The method of administration and dose can be adjusted depending on the therapeutic effect.

Drops should be taken 30-40 minutes before meals, dissolving in a glass of water or dripping on a piece of sugar. Tablets are taken before meals, the maximum allowed number of capsules per day - 6 pieces. Duration of therapy is 10-14 days, repeated course is carried out after a break of 1-2 weeks.

Use of the barbovale during pregnancy

To treat disorders of the nervous system in women during gestation and lactation it is recommended to use sedative preparations on a plant basis. Use during pregnancy Barbovan is contraindicated. This is due to the activity of its components, which can penetrate the placental barrier.

Contraindications

Barboval has certain contraindications to the use. This applies to children of childhood, pregnant and breastfeeding. The drug is not used when hypersensitivity to its active and auxiliary components.

Since Barbowala contains phenobarbital, it can cause the development of Lyell's syndrome or Stevens-Johnson in the first days of treatment. Long-term therapy is a risk of drug dependence and bromine poisoning. With special care, drops are prescribed to patients with arterial hypotension, with acute and persistent pain, decompensated heart failure, drug intoxication, adrenal hypofunction, hyperkinesia and hyperthyroidism.

If these recommendations are not followed, unfavorable symptoms from the side of the central nervous system and other body systems are possible.

Side effects of the barbovale

The medication is well tolerated. Side effects are extremely rare and, as a rule, due to the use of high doses of drops. Patients can complain of the occurrence of attacks of nausea and vomiting, increased drowsiness, headaches and dizziness, lacrimation.

There is no specific antidote. The side symptomatology disappears immediately after the drug is discontinued or the dosage is reduced.

Overdose

The use of high doses or excess of the prescribed course of treatment causes symptoms of an overdose. It is expressed as oppression of psychomotor reactions, headaches, dizziness, increased drowsiness, general weakness, nausea and vomiting.

Signs of an overdose are eliminated after a reduction in dosage or the abolition of drops / tablets. If the side effects are pronounced and signs of severe intoxication are present, it is recommended to take stimulants of the central nervous system (Etymizol, Bemegrid, Caffeine and others).

Interactions with other drugs

Barbowan can be used in combination therapy for CNS disorders and other diseases. Interaction with other drugs is regulated by the attending physician. With simultaneous use with neuroleptics and tranquilizers, Barbowal potentiates their effect. When combined with stimulants of the central nervous system, a decrease in the effectiveness of each drug is observed.

Psychotherapy is not recommended for use with drugs that are metabolized in the liver (indirect coagulants, antibiotics, sulfonamides). This is explained by the action of phenobarbital, which induces microsomal enzymes and reduces the effectiveness of drugs. Alcohol enhances the effect of the sedative and increases its toxicity.

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Storage conditions

In the dark place at a temperature of no higher than 25 ° C.

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Shelf life

Barboval should be used within 36 months from the production date (indicated on the bottle with drops and on the capsule packaging). At the end of this period, the drug is contraindicated to take and must be disposed of.