Nasik

Medicinal drug Nazik is an effective nasal agent for external use. Nasik refers to derivatives of xylometazoline and is prescribed for the treatment of diseases of the upper respiratory tract.

Indications Nasik

Nasik can be used:

• with swelling of the nasal mucosa, which accompanies an acute cold;
• with mechanical damage to mucous membranes in the nasal cavity and on the inner surfaces of the wings of the nose;
• with vasomotor rhinitis;
• with swelling of the mucosa after surgery in the nasal cavity.

[1]

Release form

Nasik is produced in the form of an intranasal spray, 10 ml each in a bottle with a nozzle for spraying the drug. The drug is a clear, colorless solution with the main ingredients of xylometazoline and dexpanthenol. One injection usually contains 0.1 mg of xylometadolin and 0.5 g of dexpanthenol. The drug is dispensed without a prescription.

Pharmacodynamics

Nasik is a complex drug that combines the action of sympathomimetic and vitamin B5 analogue. This combination allows to achieve vasoconstrictive and anti-edematous effect.

Xylometazoline h / s shows sympathomimetic properties, improving nasal breathing and speeding up mucus from the nose.

Dexpanthenol has a bioactivity similar to vitamin B5. This vitamin accelerates metabolic processes, promotes the production of antibodies and strengthens immunity at the local level.

In addition, the drug Nazik provides protection of the superficial mucous layers and helps the early healing of wounds. 

[2],

Pharmacokinetics

The effect of the drug is observed already after 5-10 minutes after spraying.

Some of the active ingredient of xylometazoline undergoes systemic absorption, which can affect the work of the nervous and cardiovascular systems.

Dexpanthenol binds to plasma proteins and spreads through the circulatory system. It is assumed that approximately 65% of the dose is excreted through the kidneys and about 35% - with feces. 

[3], [4]

Dosing and administration

Nasik is prescribed for adults or children over six years of age. The drug is sprayed into each nostril opening up to 3 times a day. The spray bottle must be positioned vertically. Simultaneously with the pressure, a sharp inhalation of the patient through the nose should follow.

To avoid side effects, it is not recommended to use Nazik for more than one week in a row. Therefore, in the treatment of chronic rhinitis should be replaced in a timely manner, drugs after consultation with your doctor.

Nasik can not be used in patients younger than six years of age. In pediatrics it is recommended to use a special drug - Nasik for children.

[8]

Use Nasik during pregnancy

Nasik is not recommended for use by pregnant and lactating women, as studies on the effect of the drug on the baby's body and on the course of pregnancy have not been conducted.

Contraindications

The main contraindications that exclude the use of Nazik are:

• propensity to allergic reactions to the components of the drug;
• atrophic changes in the nasal mucosa;
• acute cardiovascular pathologies;
• Thyroid gland diseases;
• increased intraocular pressure;
• surgical interventions with exposure of the meninges;
• taking drugs-MAO inhibitors;
• pregnancy and breastfeeding;
• children's age till 6 years.

Relative contraindications, in which Nasik appoint with great caution, are:

• presence of pheochromocytoma;
• taking drugs that increase blood pressure;
• hyperplasia of the prostate;
• disorders of pigmentary metabolism (porphyrin disease).

[5], [6],

Side effects Nasik

The development of side effects can be observed with chaotic or prolonged use of the drug Nazik. Among the most common side effects can be identified:

• irritability, sleep disturbances, a feeling of constant fatigue, pain in the head;
• heart palpitations, high blood pressure, irregular heartbeat rhythm;
• convulsive syndrome;
• allergic reactions (rashes, swelling);
• deterioration of visual functions;
• dyspeptic disorders;
• desiccation of the mucous nasal cavity, bleeding from the nose, burning.

After the drug is discontinued, the side effects usually go away on their own and do not require additional treatment.

[7]

Overdose

The use of Nasik in inadequately high doses, as well as the use of the drug inside, can provoke disruption of the nervous and cardiovascular systems, which is manifested by spastic conditions, slowing of the heart rhythm, coma, difficulty breathing, increased blood pressure.

The nervous system can respond to a Nazik overdose with the appearance of anxiety, hallucinations, seizures, the development of depressive states and a decrease in body temperature.

Additional signs of overdose may include:

• narrowing or dilating pupils;
• increased sweating;
• pallor of the skin;
• heart rhythm disturbances;
• shock, changes in blood pressure;
• violation of respiratory function;
• a disorder of consciousness.

When using the drug inside, you should induce vomiting, take activated charcoal or a laxative. If necessary, conduct symptomatic therapy.

Interactions with other drugs

Combined application of Nasik with MAO inhibitor drugs, β-blockers or antidepressants may provoke an increase in blood pressure values, due to the effect of the listed drugs on the state of the cardiovascular system.

[9], [10]

Storage conditions

The drug Nazik does not require any specific storage conditions. However, children's access to the storage site of the drug should be limited

Shelf life

Shelf life of the sealed drug is up to 3 years. After opening, the Nazik should be used for 4 months, after which the medicine must be discarded.