Nazol Advance

Preparation-α-adrenomimetic, decongensant Nazole Advance is intended for intranasal external use, for the treatment of the common cold and elimination of pathological discharge from the nose of various etiologies. 

[1], [2]

Indications Nazol Advance

Nasal Advance can be used to eliminate nasal secretions and alleviate symptoms of rhinitis of various origins:

• with discharge from the nose, which accompany SARS or ARI;
• with vasomotor or allergic rhinitis;
• at a genyantritis or a sinusitis.

 Also Nasol Advance can be used to prepare for conducting diagnostic procedures or operations in the nasal cavity.

[3], [4]

Release form

Spray Nazol Advance is released in plastic or polyethylene bottles with a built-in nebulizer, 15 or 30 ml of 0.05% of the drug. Drops have the appearance of a clear solution, with a slight aroma of mint and camphor. Each flacon is packed in a separate cardboard box with instructions.

The active ingredient is oxymetazoline g / 0.05 g. In addition to it, additional components are also present (benzalkonium chloride, sodium dihydrogen phosphate, sodium hydrogenphosphate, menthol, eucalyptol, camphor, etc.).

[5], [6], [7]

Pharmacodynamics

Spray Nazol Advance refers to the external vasoconstrictor. The active ingredient oxymetazoline is an α-adrenergic stimulant that activates adrenoreceptors located in the smooth muscles of the nasal vasculature.

Nasal Advance blocks the discharge from the nose of any origin. The active substance oxymetazoline rapidly narrows the surface vessels, reduces the signs of swelling of the mucous tissues, facilitates breathing through the nose.

[8], [9], [10], [11],

Pharmacokinetics

The action of oxymetazoline begins to manifest itself immediately after application of the drug to the mucous membranes and intensifies within 10-15 minutes. The duration of the vasoconstrictive effect is up to 10 - 12 hours.

Systemic absorption of the active component is negligible. Excretion is performed by the urinary system (more than 2%) and the intestine (more than 1%).

[12], [13], [14], [15], [16],

Dosing and administration

Nasol Advance is administered intranasally:

• adults and children from 12 years inject 2-3 doses of 0.05% of the drug up to 2 times a day;
• children 6-12 years old injected 1 dose into each nostril opening up to 2 times a day. The frequency of application of the drug is 1 time every 12 hours.

The duration of the treatment course is up to 3 days.

During injection, do not throw your head back or lie in a lying position. The bottle must be held vertically during injection.

[24], [25], [26], [27], [28], [29]

Use Nazol Advance during pregnancy

Use of Nazole Advance during child-bearing is not recommended. There is no reliable information on the safety of the drug for the course of pregnancy and fetal development.

In the period of lactation, use of drugs based on oxymetazoline is contraindicated. Including this applies to the spray Nazol Advance.

Contraindications

• Hypersensitivity to oxymetazoline, a tendency to allergic reactions to other components Nazol Advance.
• Disorders of metabolic processes (thyroid disease, diabetes mellitus).
• Increased intraocular pressure.
• Atrophy of the nasal mucosa.
• Simultaneous treatment with MAO inhibitor drugs, or other means that increase blood pressure.
• Hypertension.
• Pregnancy and lactation period.
• Pheochromocytoma.
• Children up to 6 years of age.

[17], [18], [19]

Side effects Nazol Advance

With prolonged use of Nazol Advance, the following side effects may develop:

• pain, itching and burning in the nasal cavity;
• redness, thinning and overdrying of the mucosa;
• stuffiness in the nose, medicated rhinitis;
• tachycardia, increased blood pressure, heart pain;
• allergy (rash, hives, angioedema);
• nausea;
• atrophic changes in the mucosa, frequent bleeding from the nose;
• poor sleep, irritability;
• sneezing;
• headache.

To prevent the occurrence of adverse events, it is not recommended to use Nasol Advance for a long time, as well as to exceed recommended doses.

[20], [21], [22], [23]

Overdose

When using the drug Nazol Advance for more than 4 consecutive days, as well as accidental ingestion of the solution, there may be signs of overdose:

• dyspeptic disorders;
• spasms of peripheral vessels;
• increased blood pressure;
• convulsions.

Often overdose is accompanied by depression of the central nervous system, which is manifested by fatigue, drowsiness, development of coma.

When swallowing the drug is recommended to wash the stomach, take sorbent drugs. If necessary, perform symptomatic treatment.

[30], [31], [32]

Interactions with other drugs

In combination with other means that can narrow the blood vessels, there may be an increase in side effects.

Oxymetazoline impairs the absorption of other nasal drops and lengthens the period of their action, and also increases the effect on the central nervous system of MAO inhibitor preparations.

It is not recommended to carry out long-term treatment with Nazol Advance, since this can provoke the development of atrophic changes in the mucous epithelium. For the same reasons, several local vasoconstrictors should not be used simultaneously.

For the treatment of chronic forms of rhinitis, if prolonged treatment is necessary, Nazoval Advance is administered in combination with other medications, depending on the cause of the common cold.

[33], [34], [35], [36], [37], [38]

Storage conditions

Nasal Advance is recommended to store in dark, dry places, away from children's access. The optimum temperature regime for the preservation of nasal spray is from + 2 ° C to + 25 ° C.

[39]

Shelf life

Shelf life of the spray Nazol Advance - up to 2 years.

[40]