Helex sr

Helex sr are tablets for the treatment of psychoneurological disorders. Consider the indications for their use, dosage, possible side effects and contraindications.

The drug is prescribed for symptomatic therapy of depressive and anxious conditions. Pharmacological group of the drug - tranquilizers.

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Indications Helex sr

Since the drug is included in the category of tranquilizers, it can only be used for medical purposes. Let's consider the main indications for the use of Helex:

• Neuroses
• Alarm states
• Constant sense of danger
• Anxiety
• Long-term stress
• Deterioration and loss of sleep
• Irritability
• Somatic disorders
• Neurotic reactive-depressive disorders
• Anxious-depressive conditions
• Decreased appetite against anxiety
• Phobias
• Panic disorders

If Helex is prescribed to patients with endogenous depression, then combined therapy is used in combination with antidepressants. Long-term use of tablets may cause the development of manic and hypomanic state. With special care, the remedy is prescribed for patients with impaired renal and hepatic function.

Abrupt cancellation or rapid dose reduction causes a number of adverse effects. Patients complain of insomnia, spasms in the abdomen and skeletal muscles, a slight weight loss, vomiting, increased sweating, convulsions and tremors of the extremities. During the use of this drug is contraindicated in the use of alcohol, it is also recommended to abandon the driving of vehicles and management mechanisms.

[2], [3], [4], [5]

Release form

The drug is released in the form of tablets for oral administration. The release form allows you to calculate the therapeutically necessary dosage. Each package contains 2,3 and 6 blisters with a dosage of 0.5 mg, 1 mg and 2 mg of alprazolam.

The basic physicochemical properties of the tablets indicate their modified release. 0,5 mg - green-yellow, round, biconvex; 1 mg - white, round capsules and 2 mg - light blue slightly biconvex, round tablets.

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Pharmacodynamics

The medicament contains the active substance alprazolam, a derivative of triazolo-benzodiazepine. Pharmacodynamics indicates that the active component has anticonvulsant, hypnotic, sedative and anxiolytic effect. The mechanism of action is based on the inhibition of endogenous GABA in the central nervous system due to an increase in receptor sensitivity to the mediator due to the stimulation of benzodiazepine receptors (located in the allosteric center). The drug inhibits polysynaptic spinal reflexes and reduces the excitability of the subcortical structures of the brain.

Reduction of emotional tension, anxiety and anxiety occurs simultaneously with hypnotic action. Tablets reduce the period of falling asleep, increase the duration of sleep and reduce the number of nocturnal awakenings. Sleeping action is based on the inhibition of cellular structures of the reticular formation of the brain stem. Sleeping reduces the impact of vegetative, emotional and motor stimuli.

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Pharmacokinetics

Tablets are quickly and completely absorbed from the gastrointestinal tract. Pharmacokinetics indicates the maximum concentration in the blood plasma within 1-2 hours after oral administration.

The level of binding to blood plasma proteins is 80%. The active substance is metabolized in the liver. The half-life is 12-15 hours. Alprosolam is excreted as metabolites by the kidneys.

[8], [9], [10]

Dosing and administration

To achieve a therapeutic effect, the use of any medication must be controlled by the attending physician. The method of administration and dose of Helex are selected individually for each patient. Usually, the minimum effective dosage is used, which is adjusted during therapy depending on the result achieved and tolerability. If an increase in dose is required, this should occur gradually to prevent adverse reactions.

For a start take 2.5-5 mg 2-3 times a day, if necessary, increase to 4.5 mg. For elderly patients and with a weakened immune system, the recommended dose is 2.5 mg 2-3 times a day, maintaining 5-7.5 mg per day. Consider the main treatment regimen that is suitable for most patients:

• Anxious and anxious-depressive disorders - 1 mg once a day or 0.5 mg for two divided doses. As maintenance therapy take 4 mg per day, divided into 2 admission of 2 mg.
• Panic disorders - 0.5 mg at bedtime, maintaining a dose of 1 mg.

The cessation of treatment should be gradual, as a sharp cancellation provokes relapses of the underlying disease. The abolition of tablets is carried out for a long period of time with a gradual decrease in the daily dose of 0.5 ml every 2-3 days. When withdrawal syndrome occurs, recovery of the previous treatment regimen is required until the patient's condition stabilizes.

[14],

Use Helex sr during pregnancy

During pregnancy, many expectant mothers face depressive and anxiety disorders. For their elimination prescribe safe, but effective drugs, usually on a plant basis. The use of Helex during pregnancy is contraindicated. This is due to the mechanism of action of the active component. Alprosolam increases the risk of congenital malformations in the fetus, as it has a toxic effect. Long-term use of the drug leads to physical dependence and the development of withdrawal syndrome in a child.

The use of Hepx on late gestation causes depression of the fetal CNS. The use of tablets before or during labor can lead to respiratory depression in the newborn, hypothermia, hypotension, and decreased muscle tone. Medication is not used during lactation, since the active substance in the form of metabolites is excreted in breast milk, provokes drowsiness and difficulty feeding the baby.

Contraindications

Tranquilizers have many restrictions on use, since they have a depressing effect. Basic contraindications for use:

• Pregnancy and lactemia
• Age of patient under 18 years of age
• Closed-angle glaucoma
• Acute poisoning with alcohol, sleeping pills and psychotropic substances, opioid analgesics
• Myasthenia gravis
• Coma, shock
• Chronic obstructive airway disease
• Respiratory failure
• Severe depression
• Hypersensitivity to benzodiazepines

[11], [12]

Side effects Helex sr

Self-use of Halex causes a number of negative symptoms. Side effects of Helex are manifested by many organs and systems:

• Central nervous system - drowsiness, increased fatigue, decreased concentration, disorientation, headaches, limb tremor, slowing of mental and motor reactions, confusion, muscle spasms.
• Digestive system - increased salivation, dry mouth, nausea and vomiting, heartburn, diarrhea and constipation, heartburn, jaundice, impaired liver function.
• The hemopoietic system is anemia, neutropenia, leukopenia, thrombocytopenia.
• Genitourinary system - incontinence / urinary retention, decreased / increased libido, dysmenorrhea, impaired renal function.
• Endocrine system - disorders of the menstrual cycle and libido, changes in body weight, skin allergic reactions.
• Cardiovascular system - tachycardia, lowering blood pressure.

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Overdose

With prolonged treatment and the use of large doses of Hleks, a number of adverse reactions occur. Overdose manifests itself by such symptoms:

• Impairment of consciousness
• Drowsiness
• Superficial breathing
• Arterial hypotension
• Ataxia

To eliminate these symptoms, the patient should be vomited and gastric lavage performed. Absorption of active substances decreases with the use of absorbents and salt laxatives. The patient should be under medical supervision.

[15], [16]

Interactions with other drugs

Helex has certain limitations when used concomitantly with other medicines as part of complex therapy. Interaction with other drugs should be controlled by the attending physician. So, when using psychotropic and anticonvulsant drugs with ethanol, CNS depression is observed. The blockers of histamine H2 receptors increase the CNS depression and decrease the clearance of the active substance.

With the simultaneous administration of hormonal oral contraceptives and Helex, the elimination period increases. When interacting with dextropropoxyphene, an increase in the concentration of the active substance in the blood and an inhibition of the central nervous system are observed. Digoxin increases the risk of intoxication, and ketoconazole increases the action of alprazolam. Paroxetine increases the effectiveness of the tranquilizer, and fluvoxamine causes side effects due to an increase in the level of alprazolam in the blood.

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Storage conditions

The drug should be kept in its original packaging, protected from moisture, sunlight and inaccessible to children. Compliance with storage conditions allows you to prevent damage to the drug. Storage temperature should not exceed 30 ° C.

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Shelf life

Helex sr must be used within 24 months from the production date. After the expiry date of the tablet is forbidden to take and must be disposed of. The drug is released only on the prescription.

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