Celecoxib Norton

To treat systemic diseases of connective tissue, only modern medications are used. Consider one of these drugs - celecoxib-norton, indications for use and its therapeutic effect.

The drug belongs to the category of non-steroidal anti-inflammatory drugs.

The inhibition of the enzyme cyclooxygenase stops the formation of prostaglandins. The drug does not inhibit COX-1, and the increase in COX-2 activity is a response to the effect of anti-inflammatory factors that synthesize the accumulation of prostaglandins, especially E2. When therapeutic doses are used, the synthesis of constitutional prostaglandins is not impaired and there is no adverse effect on the physiological processes in the tissues (stomach, intestine, duodenum).

[1], [2], [3]

Indications Celecoxib Norton

The drug is prescribed for patients of adult age with connective tissue diseases.

Indications for use Celecoxib:

• Osteoarthritis is a pathological process of wear of the joint apparatus of the limbs. Occurs as a result of injuries sustained, injuries or with hereditary predisposition. As a rule, it affects the knee joints in women, it rapidly progresses, it gives the expressed painful sensations, has several types and stages of development.
• Rheumatoid arthritis is a systemic inflammatory disease that affects connective tissues. It is characterized by progressive erosive-destructive processes. The disease is autoimmune, as it occurs when the immune system is malfunctioning. It occurs in 2% of the world's population, affects symmetrical joints of feet and bones.

[4], [5]

Release form

The antirheumatic agent is released in the form of capsules for oral administration. The chemical name of the drug is diaryl-substituted pyrazole. The release form allows you to calculate the number of tablets needed to complete a full course of treatment.

Each capsule contains 100 mg or 200 mg of active ingredient - celecoxib. Capsules gelatinous, firm, with green 100 mg or pink 200 mg a cover with the maintenance of white crystalline powder. Auxiliary components: silicon colloidal anhydrous, calcium phosphate doprosnovnoy, corn starch, lactose, sodium starch glycolate and other substances.

Pharmacodynamics

The medicinal effectiveness of celecoxib is based on its mechanism of action. Pharmacodynamics indicates that celecoxib belongs to the category of non-steroidal, antirheumatic and anti-inflammatory drugs. Anesthetic action is based on antipyretic activity.

The drug inhibits the synthesis of prostaglandins by selective inhibition of the enzyme cyclooxygenase, which takes part in inflammatory processes. Tablets should be taken only with appropriate indications and medical clearance.

[6], [7], [8]

Pharmacokinetics

After ingestion, celecoxib norton is rapidly absorbed in the digestive tract, the maximum concentration in the blood plasma occurs in 3 hours. If the tablets are taken concomitantly with food, then it slows down the absorption by 1-2 hours. Pharmacokinetics is proportional and linear to the accepted dose. Binding to blood plasma proteins - 95-97%.

The active substance is metabolized in the liver by hydroxylation, oxidation and glucuronation. It is excreted mainly with bile in the form of metabolites. About 3% is excreted in urine and feces unchanged. At repeated application the half-life takes 8-12 hours, and the concentration in the blood plasma is reached during 5 days.

[9], [10]

Dosing and administration

The medication is intended for oral use. The method of application and dose of celecoxib depends on the indications for its use. Doctors recommend a minimally effective dose with a shorter course of treatment.

• Osteoarthritis - 100 mg twice a day or once 200 mg.
• Rheumatoid arthritis - up to 200 mg twice a day (the dosage depends on the severity of the patient's condition).

If the drug is prescribed for patients over 65 years of age, the daily dose should not exceed 200 mg. The duration of therapy depends on the clinical condition of the patient and, as a rule, does not exceed 15 days. To prevent irritation of the mucous membrane of the esophagus, the capsule should be swallowed without chewing, squeezed with copious amounts of liquid.

[14], [15], [16]

Use Celecoxib Norton during pregnancy

Use of the drug in the first trimester of gestation is contraindicated. This is associated with an increased risk of development of malformations and pathologies (heart defects, wolf mouth). The use of celecoxib during pregnancy is possible only with appropriate medical indications, when the benefit to the mother is higher than the potential risks to the fetus. Contraindications are due to the fact that the active component penetrates through the placental and GEB barrier.

If the capsules are taken in the third trimester, then this may trigger a perenashivanie and a significant weakening of labor. The use of medication during lactation in a moderate dosage is possible. When taking high doses, breastfeeding should be stopped.

Contraindications

The use of celecoxib is possible only with appropriate indications and medical clearance. This is due to the fact that the medicine causes negative reactions from many organs and systems.

Contraindications:

• Individual intolerance of the active ingredient and auxiliary components.
• Predisposition to the development of allergic reactions (urticaria, rhinitis, bronchospasm) with non-steroidal anti-inflammatory drugs and aspirin.
• Pregnancy and lactation.
• Patients under the age of 18 years.

Side effects Celecoxib Norton

If the drug is taken without compliance with medical recommendations with an independent selection of dosage, this causes a number of side effects.

Celecoxib can cause such disorders as:

• Flatulence, diarrhea, constipation, abdominal pain.
• Various disorders of the nervous system (headaches, insomnia, dizziness).
• Infections of the upper respiratory tract.
• Back pain.
• Peripheral edema.
• Rhinitis and pharyngitis.

Side effects of celecoxib are reduced by using the lowest effective dose in a short course of treatment. If the pills are prescribed to elderly patients, the side effects are amplified and pronounced with prolonged admission. With prolonged therapy, regular monitoring of the patient's condition is provided.

[11], [12], [13]

Overdose

Failure to comply with the rules of use of the drug provokes various adverse symptoms. Overdose occurs when the dose prescribed by the doctor is exceeded.

Signs of an overdose:

• Intoxication of the body, which is accompanied by vomiting, painful sensations in the epigastric region, nausea, noise in the ears, decreased visual acuity and hearing, dizziness.
• With a severe overdose, there are disturbances in thinking, drowsiness, limb tremor, shortness of breath, clouding of consciousness, dehydration and hyperthermia.

To eliminate the above symptoms, the stomach is washed. Depending on the acid-base and electrolyte balance, the infusion solution of sodium lactate, sodium bicarbonate and sodium citrate is prescribed.

[17], [18], [19]

Interactions with other drugs

Use of any medicinal product with other medicines is possible only with the appropriate medical recommendations. Contraindicated interaction with other drugs - anticoagulants, including aspirin, as this can enhance their effect.

Possible simultaneous use with Teofillinom, Digoxin, Warfarin, Glibenclamide and antacids. Such interaction does not cause clinically significant disorders. But do not forget that non-steroidal anti-inflammatory drugs reduce the clearance of lithium, which increases its level in blood plasma and toxicity. 

[20], [21], [22],

Storage conditions

The medicinal effect of the drug depends largely on the storage conditions. Celecoxib-Norton should be kept in its original packaging, protected from sunlight, moisture and inaccessible to children.

Storage temperature should not exceed 25 ° C. If these recommendations are not observed, the drug loses its properties and can cause uncontrolled adverse reactions from many organs and systems.

[23], [24], [25], [26], [27], [28]

Shelf life

The mechanism of action of the drug depends on its duration. This is due to the fact that the use of overdue drugs is unsafe for the patient's body and causes many pathological symptoms. Celecoxib is taken within 36 months from the date of manufacture, which the manufacturer indicates on the packaging of tablets. At the end of this period, the capsules must be disposed of.

Celecoxib-norton is dispensed only on the prescription. This reduces the risk of adverse reactions due to self-administration of the drug. So, it improves the results of therapy of inflammatory diseases of joints and bones.

[29], [30]