Life 900

A medicinal product related to plant antidepressants, Life 900 has been developed and manufactured by the German company Steigerwald Arctneimittelwerk GmbH. The high effectiveness of the antidepressant characteristics of this drug has been proved by numerous clinical studies conducted on the basis of several hospitals and medical centers. 

If a person is depressed or is experiencing a prolonged depression, but the manifestations of this condition are embedded in the clinical picture of symptomatic manifestation of mild or moderate severity, then the medicinal product related to plant antidepressants, Life 900 is an excellent highly effective pharmacological preparation that can quickly and without serious consequences. The patient acquires former confidence and efficiency, mood, and with it the quality of life, improves. There is only one "but". This drug should be prescribed only by a qualified specialist, independent treatment can only aggravate the health situation, leading to severe, sometimes irreversible, complications.

Indications Life 900

Relying on those pharmacological characteristics that were obtained in the development of the drug under consideration, indications for the use of Life 900 are reduced to a qualitative relief of such a pathological disorder affecting the human body as a state of depression that is assessed by mild or moderate severity. In this case, a person experiences:

1. Depressed mood.
2. Emotional instability.
3. Feeling of chronic fatigue.
4. Increased irritability.
5. He has an inadequate reaction to external stimuli.
6. There is a deterioration in the level of work capacity.

[1], [2]

Release form

Pharmacology of the medical product under consideration Life 900 is quite narrowly applicable. Does not differ a great variety and its form of release. In the pharmacy market, this medicine is presented only in the form of tablets coated with a protective film shell and collected in a blister of 20 units.

Cardboard packaging can be composed of No. 20, No. 60 and No. 100, that is one, three and five blisters in the package. At the same time, the concentration of the main active substance of the drug, which is the dry extract of St. John's wort, is 900 mg.

[3]

Pharmacodynamics

This drug belongs to the pharmacotherapeutic group of plant antidepressants and has the encoding of ATS N06AP01. Therefore, the pharmacodynamics of Life 900 is directly caused by the individual characteristics of the herb extract of St. John's wort, active active compound of which is hypericin. It works as a protection, preventing a failure in neurotransmitter transmissions. If we analyze the mechanism of this action, it turns out that hypericin to some extent blocks the seizure of serotonin and dopamine in presynaptic neurons, norepinephrine of monoamine neurotransmitters.

The main element of Life 900 effectively reduces the effectiveness of catechol-0-methyltransferase and monoamine oxidase. This substance quite well inhibits the proliferation and spread of Gram-positive bacteria that belong to a bacterial group such as Streptococcus agalactiae and Streptococcus pyogenes, it also works in the presence of methicillin-resistant strains of Staphylococcus aureus or penicillin resistant strains.

Flavonoids, which are present in the composition of this medicinal plant, effectively affect the benzodiazepine receptors, causing the process of extinguishing the excitation amplitude, which leads to a calming effect.

In this case, flavonoids work as a highly effective anti-inflammatory agent.

An increased production of norepinephrine is provoked, which leads the patient's body to relieve psychological stress, arresting the depressive mood and feelings of anxiety. At the same time there is a normalization of sleep, stimulation of appetite, mood, increase of working capacity and restoration of vitality, sensation of vivacity.

The preparation Life Life 900 pharmacologists are classified as low-toxic compounds. But in the recommended dosages, he does not have a negative effect on the human body.

[4], [5], [6], [7], [8], [9]

Pharmacokinetics

The pharmacokinetics of Life 900 is due to the kinetic characteristics that the constituent components of the drug in question possess.

Due to their belonging to lipophilic compounds, hypericins easily overcome the blood-brain membrane, having a positive effect on the state of the central nervous system and its performance.

After a single dose of the recommended dose of Life 900, an average of 7.9 hours (this figure can fluctuate ± 90 minutes due to the individual characteristics of the body), the blood reaches the maximum concentration of hypericin, which corresponds to 3.8 ng / ml. This indicator can also fluctuate within ± 1.2 ng / ml due to the individual characteristics of the patient's body.

The maximum concentration (Cmax) of pseudo-hypericin in the blood (with an index of 10.2 ± 3.9 ng / ml) is determined after 2.7 hours ± 40 minutes after oral administration of Life 900.

The maximum concentration (Cmax) of hyperphorin in the plasma (with an index of 122 ± 45.5 ng / ml) is determined after 4.5 hours ± 70 minutes after dosing of Life 900 inside.

The half-life of the drug compound (T1) for hypericin corresponds to an average time interval of 18.7 hours, which can fluctuate within ± 4 hours 50 minutes.

The half-life period (T1) for pseudo-hypericin corresponds to an average time interval of 17.2 hours, which is capable of fluctuating within time limits of ± 8 hours 25 minutes.

The half-life of the pharmacological compound (T1) for hyperforin is in the mean of 17.5 hours ± 4 hours 30 minutes.

When the optimal mode of taking Lifa 900 was taken, the observations confirmed that the physiological stability of the patients' psychological state was fixed after four days. From this period, physicians begin to fix permanently - a stable level of hyperforin in the patient's blood plasma.

[10], [11], [12]

Dosing and administration

Based on the established degree of manifestation of the psychological disorder, the picture of the course of the disease and the bouquet of concomitant pathologies that are in the patient's anamnesis, the treating doctor prescribes both the way of applying and the dose of Life 900.

For an adult patient, pharmacologists recommend drinking the drug in question one tablet per day for one day. To obtain maximum effectiveness of treatment, the drug is not recommended to chew. It is desirable to drink this medicine together with a sufficient amount of water after a morning meal.

The maximum permissible daily dosage of Life 900 is 0.9 g, which corresponds to the dose of one tablet.

The action of the medicament is cumulative, which requires its continuous adoption, not allowing breaks in taking the medicine. The duration of the drug course is two weeks. But this indicator can be adjusted by a specialist depending on the severity of the pathology, the nature of its course and the effectiveness of therapy.

If the treatment period is extended to four weeks, and the expected improvement is not observed, Life 900 therapy should be discontinued and consulted by a specialist.

[16], [17], [18]

Use Life 900 during pregnancy

The time of conception, gestation and birth of a baby is the happiest and most responsible period in the life of any woman. Many future mothers during this period try to minimize the use of pharmacological drugs, fearing their negative impact on the development of the fetus. And it is right. After all, any medicinal product is a combination of substances and chemical compounds, which to some extent affect the entire human body. Especially dangerous is the influence during the formation of organs and systems of the embryo, which is observed against the background of the first trimester of gestation. 

Despite its naturalness, thanks to the manufacture of vegetable raw materials, safe and effective use during pregnancy, Life 900 has not been reasonably proved. Therefore, in order not to get negative symptoms and consequences, it is worthwhile during this period, as well as during the feeding of a newborn baby with a breast, to refrain from taking Life 900 for the relief of a depressed state of a pregnant woman.

Contraindications

To date, monitoring of admission of the funds in question has confirmed minor contraindications to the use of Life 900. Such deviations are attributed to physicians:

1. Increased intolerance of the patient's body to one or several components of the drug.
2. Depression of severe severity.
3. The presence in the patient's history of photosensitization (increased sensitivity of the body to the action of ultraviolet or visible radiation).
4. Contraindicated in taking this drug and children who are not yet twelve years old.
5. This drug affects the reaction rate, so during treatment, a person should not sit behind the wheel and manage complex (dangerous in terms of injury) mechanisms.
6. Do not take Life 900 with a number of other pharmacological agents. Such incompatibility is described below in the subsection "Interactions with other drugs":

• A number of antiretroviral drugs.
• Antiepileptic means.
• Drugs to reduce blood clotting.
• Pharmacological agents related to the contraceptive group.
• And a number of others.

[13], [14]

Side effects Life 900

The dosages recommended in the instructions attached to the drug do not cause any negative symptoms. But still, due to the individual characteristics of the body or when taking higher doses of Life 900, the patient may experience
Side effects of the drug in question.

It can be:

1. Dizziness.
2. Occurrence of a short-term or constant pain in the head.
3. Sensation of dryness of oral mucosa.
4. Violations affecting the functioning of the digestive system.
5. If a patient has a history of photosensitization, the adoption of Life 900 on the background of being exposed to direct ultraviolet or visible radiation, can lead to burns of the skin.
6. Perhaps the appearance of skin allergic reactions: hyperemia, pruritus, rash.
7. The patient may feel a decrease in general tone, increased fatigue.
8. Reverse reaction to the drug: the emergence of increased anxiety, in persons with bipolar depression, there is a growing likelihood of transforming the problem into a manic - depressive state.

If even one of the above manifestations appears, you need to seek advice and help from your doctor.
 

[15]

Overdose

If the patient carelessly refers to the schedule and dosages of taking the medication prescribed in the protocol of treatment, the amount of chemical compound that has entered the body can be exceeded. Overdose of the leading active chemical component Life 900 can also be manifested due to the individuality of the manifested sensitivity of the organism of the sick person. Pathological symptoms can be expressed as an allergic reaction to the skin. The second manifestation of an overdose may be the appearance of phototoxicity, that is, burn foci, which appeared under the influence of the solar radiation spectrum. In this clinical picture, the medication should be stopped.

In the rest, any pathological symptomatology when used in the protocol of cupping of the medicine in question is not revealed.

[19], [20]

Interactions with other drugs

After passing the examination and setting the diagnosis, the doctor signs the protocol of treatment. If it is a monotherapy, then the treating physician should know as accurately as possible the features of the pharmacodynamics used in the protocol of cupping the pharmacological group of drugs.

If Life 900 is appointed as one of the elements of complex treatment, the specialist must have an idea about the peculiarities of the effects of the interaction of pairs of pharmacological preparations on each other. After ignorance of the consequences of the parallel application of various combinations of chemical compounds can provoke the development of irreversible pathological processes in a weakened organism.

The consequences of interaction with other drugs of the drug in question are determined by the group to which the partner drug belongs.

With the complex introduction of Life 900 and coumarin anticoagulants (warfarex, marevan, warfarin sodium, warfarin), the pharmacodynamic characteristics of both drugs are reduced.

In the time period of passing medical therapy with Life 900 patients should refrain from taking alcohol-containing drinks.

The extracting agent from the medicinal plant (St. John's wort) enhances the effect of those drug groups that destroy the enzymatic component of cytochrome P450.

In the case of therapeutic relief of the problem together with drugs that enhance the susceptibility of the dermis to light rays, photosensitivity can develop - the appearance of burn lesions on the skin. This symptomatology can also be maintained after the drug has been discontinued.

The mutual influence of immunosuppressants (cyclosporine, sirolimus, tacrolimus) and Life 900 is observed to decrease their properties in terms of impact on the patient's body. A similar situation is observed with the introduction of the drug in combination with cytostatics (nyrol, azafen, valdoxane, seroquel, tritico, coaxil, midazolin) and protease inhibitors (dilacor, lanicor, dilacil, lanoxin) in one treatment protocol.

In the case of tandem use, Life 900 with the medicinal representatives of its group, antidepressants (paxil, plizil, sertraline, reksitin, apo-paroxetine, adress, aktaparoxetine) in some cases may manifest symptoms of overdose or side effects (serotonergic effect).

[21], [22], [23], [24], [25]

Storage conditions

The diagnosis is made, the protocol of treatment is prescribed, it remains to purchase the drug in the pharmacy network and start treatment. But in order for the therapy to have the maximum effect, in addition to fulfilling all the doctor's recommendations, it is necessary to know the storage conditions of Life 900. If its content is incorrect, the chemical compound in question may lose or significantly reduce its pharmacodynamic characteristics and the ability to influence the sick organism. Therefore, before you start to stop the problem, you should read the instructions that are attached to any pharmacological product. 

If you follow all the recommendations, you can be sure that the level of pharmacodynamic characteristics of the drug will not decrease and will remain high throughout the life of the drug.

Requirements for the content of Life 900 is much in line with the set of recommendations that apply to the storage of most medicines:

1. The room in which the drug is stored must be protected from exposure to direct ultraviolet and other spectrum of sun rays.
2. Temperature storage should not be above +25 degrees.
3. Contain Life 900 should be in places that are not available for adolescents and young children.

[26]

Shelf life

By issuing any product to the pharmacy market, the producer corporation necessarily indicates the date on which the drug was released on the packaging material. The second number on the package indicates the end date, after which the drug in question should not be used in therapeutic treatment.

Indicates the expiration date, which for Life 900 is two years (24 months).

[27], [28]